ID   IMPA2_MOUSE             Reviewed;         290 AA.
AC   Q91UZ5;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Inositol monophosphatase 2;
DE            EC=3.1.3.25;
DE   AltName: Full=Inositol-1(or 4)-monophosphatase 2;
DE            Short=IMPase 2;
DE            Short=IMP 2;
DE   AltName: Full=Myo-inositol monophosphatase A2;
GN   Name=Impa2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=129/J;
RX   MEDLINE=21311644; PubMed=11418250; DOI=10.1016/S0378-1119(01)00502-9;
RA   Shamir A., Sjoholt G., Ebstein R.P., Agam G., Steen V.M.;
RT   "Characterization of two genes, Impa1 and Impa2 encoding mouse myo-
RT   inositol monophosphatases.";
RL   Gene 271:285-291(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: Myo-inositol phosphate + H(2)O = myo-inositol
CC       + phosphate.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-
CC       inositol from D-glucose 6-phosphate: step 2/2.
CC   -!- SIMILARITY: Belongs to the inositol monophosphatase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF353730; AAK39516.1; -; mRNA.
DR   EMBL; BC011093; AAH11093.1; -; mRNA.
DR   IPI; IPI00126255; -.
DR   RefSeq; NP_444491.1; -.
DR   UniGene; Mm.34079; -.
DR   UniGene; Mm.441590; -.
DR   HSSP; P29218; 1IMF.
DR   SMR; Q91UZ5; 17-283.
DR   PRIDE; Q91UZ5; -.
DR   Ensembl; ENSMUSG00000024525; Mus musculus.
DR   GeneID; 114663; -.
DR   KEGG; mmu:114663; -.
DR   MGI; MGI:2149728; Impa2.
DR   HOVERGEN; Q91UZ5; -.
DR   OMA; Q91UZ5; PLEITEK.
DR   BRENDA; 3.1.3.25; 244.
DR   NextBio; 368644; -.
DR   ArrayExpress; Q91UZ5; -.
DR   Bgee; Q91UZ5; -.
DR   CleanEx; MM_IMPA2; -.
DR   GermOnline; ENSMUSG00000024525; Mus musculus.
DR   GO; GO:0008934; F:inositol-1(or 4)-monophosphatase activity; IEA:EC.
DR   GO; GO:0031403; F:lithium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006020; P:inositol metabolic process; TAS:MGI.
DR   InterPro; IPR000760; Inositol_P.
DR   PANTHER; PTHR20854; Inositol_P; 1.
DR   Pfam; PF00459; Inositol_P; 1.
DR   PRINTS; PR00378; INOSPHPHTASE.
DR   ProDom; PD023420; Inositol_P; 1.
DR   PROSITE; PS00629; IMP_1; 1.
DR   PROSITE; PS00630; IMP_2; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Lithium; Magnesium; Metal-binding.
FT   CHAIN         1    290       Inositol monophosphatase 2.
FT                                /FTId=PRO_0000142521.
FT   METAL        83     83       Magnesium 1 (By similarity).
FT   METAL       103    103       Magnesium 1 (By similarity).
FT   METAL       103    103       Magnesium 2 (By similarity).
FT   METAL       105    105       Magnesium 1; via carbonyl oxygen (By
FT                                similarity).
FT   METAL       106    106       Magnesium 2 (By similarity).
FT   METAL       233    233       Magnesium 2 (By similarity).
SQ   SEQUENCE   290 AA;  31716 MW;  F27FDC7EB1D5A436 CRC64;
     MKPSSEEEGE LVQGVGPWDE CFEVAVQLAL RAGQIIRKAL TEEKRVSTKT SAADLVTETD
     HRVEDLIVSE LRKRFPSHRF IAEEATASGA KCVLTHSPTW IIDPIDGTCN FVHRFPTVAV
     SIGFAVHQEL EFGVIHHCTE ERLYTGRRGQ GAFCNGQRLQ VSRETDLAKA LVLTEIGPKR
     DPDTLKVFLS NMERLLHAKA HGVRVIGSST LALCYLASGA ADAYYQFGLH CWDLAAATVI
     IREAGGIVID TSGGPLDLMS CRVVAAGTRE MAVLIAQALQ TINYGRDDEK
//