Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q91UZ5 (IMPA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol monophosphatase 2

Short name=IMP 2
Short name=IMPase 2
EC=3.1.3.25
Alternative name(s):
Inositol-1(or 4)-monophosphatase 2
Myo-inositol monophosphatase A2
Gene names
Name:Impa2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li+ action in brain By similarity.

Catalytic activity

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactor

Magnesium By similarity.

Pathway

Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Tissue specificity

Mostly expressed in brain, small intestine, heart, kidney, and spleen (at protein level). Ref.3

Sequence similarities

Belongs to the inositol monophosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Inositol monophosphatase 2
PRO_0000142521

Regions

Region105 – 1084Substrate binding By similarity
Region207 – 2093Substrate binding By similarity

Sites

Metal binding831Magnesium 1 By similarity
Metal binding1031Magnesium 1 By similarity
Metal binding1031Magnesium 2 By similarity
Metal binding1051Magnesium 1; via carbonyl oxygen By similarity
Metal binding1061Magnesium 2 By similarity
Metal binding2331Magnesium 2 By similarity
Binding site831Substrate By similarity
Binding site2261Substrate By similarity
Binding site2331Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91UZ5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: F27FDC7EB1D5A436

FASTA29031,716
        10         20         30         40         50         60 
MKPSSEEEGE LVQGVGPWDE CFEVAVQLAL RAGQIIRKAL TEEKRVSTKT SAADLVTETD 

        70         80         90        100        110        120 
HRVEDLIVSE LRKRFPSHRF IAEEATASGA KCVLTHSPTW IIDPIDGTCN FVHRFPTVAV 

       130        140        150        160        170        180 
SIGFAVHQEL EFGVIHHCTE ERLYTGRRGQ GAFCNGQRLQ VSRETDLAKA LVLTEIGPKR 

       190        200        210        220        230        240 
DPDTLKVFLS NMERLLHAKA HGVRVIGSST LALCYLASGA ADAYYQFGLH CWDLAAATVI 

       250        260        270        280        290 
IREAGGIVID TSGGPLDLMS CRVVAAGTRE MAVLIAQALQ TINYGRDDEK 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of two genes, Impa1 and Impa2 encoding mouse myo-inositol monophosphatases."
Shamir A., Sjoeholt G., Ebstein R.P., Agam G., Steen V.M.
Gene 271:285-291(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
[3]"Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1."
Ohnishi T., Ohba H., Seo K.-C., Im J., Sato Y., Iwayama Y., Furuichi T., Chung S.-K., Yoshikawa T.
J. Biol. Chem. 282:637-646(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF353730 mRNA. Translation: AAK39516.1.
BC011093 mRNA. Translation: AAH11093.1.
RefSeqNP_444491.1. NM_053261.2.
UniGeneMm.34079.
Mm.486871.

3D structure databases

ProteinModelPortalQ91UZ5.
SMRQ91UZ5. Positions 17-283.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91UZ5.

Proteomic databases

PaxDbQ91UZ5.
PRIDEQ91UZ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025403; ENSMUSP00000025403; ENSMUSG00000024525.
GeneID114663.
KEGGmmu:114663.
UCSCuc008fly.1. mouse.

Organism-specific databases

CTD3613.
MGIMGI:2149728. Impa2.

Phylogenomic databases

eggNOGCOG0483.
GeneTreeENSGT00390000014699.
HOVERGENHBG052123.
InParanoidQ91UZ5.
KOK01092.
OMARTEVGVV.
OrthoDBEOG7RJPS8.
PhylomeDBQ91UZ5.
TreeFamTF313194.

Enzyme and pathway databases

UniPathwayUPA00823; UER00788.

Gene expression databases

ArrayExpressQ91UZ5.
BgeeQ91UZ5.
CleanExMM_IMPA2.
GenevestigatorQ91UZ5.

Family and domain databases

InterProIPR020583. Inositol_monoP_metal-BS.
IPR020552. Inositol_monoPase_Li-sen.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERPTHR20854. PTHR20854. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSPR00377. IMPHPHTASES.
PR00378. LIIMPHPHTASE.
PROSITEPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIMPA2. mouse.
NextBio368644.
PROQ91UZ5.
SOURCESearch...

Entry information

Entry nameIMPA2_MOUSE
AccessionPrimary (citable) accession number: Q91UZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot