Reviewed, UniProtKB/Swiss-Prot Q91UZ5 (IMPA2_MOUSE)

Names and origin

Protein names

Recommended name:
    Inositol monophosphatase 2
    EC=3.1.3.25
Alternative name(s):
    Inositol-1(or 4)-monophosphatase 2
      Short name=IMPase 2
      Short name=IMP 2
    Myo-inositol monophosphatase A2

Gene names

Name:

Impa2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Myo-inositol phosphate + H2O = myo-inositol + phosphate.
Cofactor	Magnesium By similarity.
Pathway	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Ligand	Lithium Magnesium Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	inositol metabolic process Ref.1 Traceable author statement. Source: MGI
Molecular function	inositol-1(or 4)-monophosphatase activity Inferred from electronic annotation. Source: EC lithium ion binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Inositol monophosphatase 2		PRO_0000142521
Sites
	Metal binding	83	1	Magnesium 1 By similarity
	Metal binding	103	1	Magnesium 1 By similarity
	Metal binding	103	1	Magnesium 2 By similarity
	Metal binding	105	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	106	1	Magnesium 2 By similarity
	Metal binding	233	1	Magnesium 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91UZ5-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: F27FDC7EB1D5A436	FASTA	290	31,716
	10 20 30 40 50 60 MKPSSEEEGE LVQGVGPWDE CFEVAVQLAL RAGQIIRKAL TEEKRVSTKT SAADLVTETD 70 80 90 100 110 120 HRVEDLIVSE LRKRFPSHRF IAEEATASGA KCVLTHSPTW IIDPIDGTCN FVHRFPTVAV 130 140 150 160 170 180 SIGFAVHQEL EFGVIHHCTE ERLYTGRRGQ GAFCNGQRLQ VSRETDLAKA LVLTEIGPKR 190 200 210 220 230 240 DPDTLKVFLS NMERLLHAKA HGVRVIGSST LALCYLASGA ADAYYQFGLH CWDLAAATVI 250 260 270 280 290 IREAGGIVID TSGGPLDLMS CRVVAAGTRE MAVLIAQALQ TINYGRDDEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of two genes, Impa1 and Impa2 encoding mouse myo-inositol monophosphatases." Shamir A., Sjoholt G., Ebstein R.P., Agam G., Steen V.M. Gene 271:285-291(2001) [PubMed: 11418250] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF353730 mRNA. Translation: AAK39516.1. BC011093 mRNA. Translation: AAH11093.1.
IPI	IPI00126255.
RefSeq	NP_444491.1.
UniGene	Mm.34079 Mm.441590
3D structure databases
HSSP	HSSP built from PDB template 1IMF based on UniProtKB P29218.
SMR	Q91UZ5. Positions 17-283.
ModBase	Search...
Proteomic databases
PRIDE	Q91UZ5.
Genome annotation databases
Ensembl	ENSMUSG00000024525. Mus musculus. [Contig view]
GeneID	114663.
KEGG	mmu:114663.
Organism-specific databases
MGI	MGI:2149728. Impa2.
Phylogenomic databases
HOVERGEN	Q91UZ5.
OMA	Q91UZ5. PLEITEK.
Enzyme and pathway databases
BRENDA	3.1.3.25. 244.
Gene expression databases
ArrayExpress	Q91UZ5.
Bgee	Q91UZ5.
CleanEx	MM_IMPA2.
GermOnline	ENSMUSG00000024525. Mus musculus.
Family and domain databases
InterPro	IPR000760. Inositol_P. [Graphical view]
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PRINTS	PR00378. INOSPHPHTASE.
ProDom	PD023420. Inositol_P. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00629. IMP_1. 1 hit. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	368644.
SOURCE	Search...

Entry information

Entry name

IMPA2_MOUSE

Accession

Primary (citable) accession number: Q91UZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	December 1, 2001
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)