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Protein

Inositol monophosphatase 2

Gene

Impa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li+ action in brain (By similarity).By similarity

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactori

Mg2+By similarity

Pathwayi: myo-inositol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase 1 (Isyna1)
  2. Inositol monophosphatase 1 (Impa1), Inositol monophosphatase 2 (Impa2), Inositol monophosphatase 3 (Impad1)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Magnesium 1By similarity1
Binding sitei83SubstrateBy similarity1
Metal bindingi103Magnesium 1By similarity1
Metal bindingi103Magnesium 2By similarity1
Metal bindingi105Magnesium 1; via carbonyl oxygenBy similarity1
Metal bindingi106Magnesium 2By similarity1
Binding sitei226SubstrateBy similarity1
Metal bindingi233Magnesium 2By similarity1
Binding sitei233SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Lithium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1855183. Synthesis of IP2, IP, and Ins in the cytosol.
UniPathwayiUPA00823; UER00788.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol monophosphatase 2 (EC:3.1.3.25)
Short name:
IMP 2
Short name:
IMPase 2
Alternative name(s):
Inositol-1(or 4)-monophosphatase 2
Myo-inositol monophosphatase A2
Gene namesi
Name:Impa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2149728. Impa2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425211 – 290Inositol monophosphatase 2Add BLAST290

Proteomic databases

EPDiQ91UZ5.
MaxQBiQ91UZ5.
PaxDbiQ91UZ5.
PRIDEiQ91UZ5.

PTM databases

PhosphoSitePlusiQ91UZ5.

Expressioni

Tissue specificityi

Mostly expressed in brain, small intestine, heart, kidney, and spleen (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000024525.
CleanExiMM_IMPA2.
ExpressionAtlasiQ91UZ5. baseline and differential.
GenevisibleiQ91UZ5. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025403.

Structurei

3D structure databases

ProteinModelPortaliQ91UZ5.
SMRiQ91UZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni105 – 108Substrate bindingBy similarity4
Regioni207 – 209Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the inositol monophosphatase family.Curated

Phylogenomic databases

eggNOGiKOG2951. Eukaryota.
COG0483. LUCA.
GeneTreeiENSGT00390000014699.
HOVERGENiHBG052123.
InParanoidiQ91UZ5.
KOiK01092.
OMAiIGIFEDG.
OrthoDBiEOG091G0D21.
PhylomeDBiQ91UZ5.
TreeFamiTF313194.

Family and domain databases

CDDicd01639. IMPase. 1 hit.
InterProiIPR033942. IMPase.
IPR020583. Inositol_monoP_metal-BS.
IPR020552. Inositol_monoPase_Li-sen.
IPR000760. Inositol_monophosphatase-like.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR00378. LIIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91UZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPSSEEEGE LVQGVGPWDE CFEVAVQLAL RAGQIIRKAL TEEKRVSTKT
60 70 80 90 100
SAADLVTETD HRVEDLIVSE LRKRFPSHRF IAEEATASGA KCVLTHSPTW
110 120 130 140 150
IIDPIDGTCN FVHRFPTVAV SIGFAVHQEL EFGVIHHCTE ERLYTGRRGQ
160 170 180 190 200
GAFCNGQRLQ VSRETDLAKA LVLTEIGPKR DPDTLKVFLS NMERLLHAKA
210 220 230 240 250
HGVRVIGSST LALCYLASGA ADAYYQFGLH CWDLAAATVI IREAGGIVID
260 270 280 290
TSGGPLDLMS CRVVAAGTRE MAVLIAQALQ TINYGRDDEK
Length:290
Mass (Da):31,716
Last modified:December 1, 2001 - v1
Checksum:iF27FDC7EB1D5A436
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353730 mRNA. Translation: AAK39516.1.
BC011093 mRNA. Translation: AAH11093.1.
CCDSiCCDS29320.1.
RefSeqiNP_444491.1. NM_053261.2.
UniGeneiMm.34079.
Mm.486871.

Genome annotation databases

EnsembliENSMUST00000025403; ENSMUSP00000025403; ENSMUSG00000024525.
GeneIDi114663.
KEGGimmu:114663.
UCSCiuc008fly.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353730 mRNA. Translation: AAK39516.1.
BC011093 mRNA. Translation: AAH11093.1.
CCDSiCCDS29320.1.
RefSeqiNP_444491.1. NM_053261.2.
UniGeneiMm.34079.
Mm.486871.

3D structure databases

ProteinModelPortaliQ91UZ5.
SMRiQ91UZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025403.

PTM databases

PhosphoSitePlusiQ91UZ5.

Proteomic databases

EPDiQ91UZ5.
MaxQBiQ91UZ5.
PaxDbiQ91UZ5.
PRIDEiQ91UZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025403; ENSMUSP00000025403; ENSMUSG00000024525.
GeneIDi114663.
KEGGimmu:114663.
UCSCiuc008fly.1. mouse.

Organism-specific databases

CTDi3613.
MGIiMGI:2149728. Impa2.

Phylogenomic databases

eggNOGiKOG2951. Eukaryota.
COG0483. LUCA.
GeneTreeiENSGT00390000014699.
HOVERGENiHBG052123.
InParanoidiQ91UZ5.
KOiK01092.
OMAiIGIFEDG.
OrthoDBiEOG091G0D21.
PhylomeDBiQ91UZ5.
TreeFamiTF313194.

Enzyme and pathway databases

UniPathwayiUPA00823; UER00788.
ReactomeiR-MMU-1855183. Synthesis of IP2, IP, and Ins in the cytosol.

Miscellaneous databases

PROiQ91UZ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024525.
CleanExiMM_IMPA2.
ExpressionAtlasiQ91UZ5. baseline and differential.
GenevisibleiQ91UZ5. MM.

Family and domain databases

CDDicd01639. IMPase. 1 hit.
InterProiIPR033942. IMPase.
IPR020583. Inositol_monoP_metal-BS.
IPR020552. Inositol_monoPase_Li-sen.
IPR000760. Inositol_monophosphatase-like.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR00378. LIIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMPA2_MOUSE
AccessioniPrimary (citable) accession number: Q91UZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.