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Q91UZ5

- IMPA2_MOUSE

UniProt

Q91UZ5 - IMPA2_MOUSE

Protein

Inositol monophosphatase 2

Gene

Impa2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li+ action in brain By similarity.By similarity

    Catalytic activityi

    Myo-inositol phosphate + H2O = myo-inositol + phosphate.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi83 – 831Magnesium 1By similarity
    Binding sitei83 – 831SubstrateBy similarity
    Metal bindingi103 – 1031Magnesium 1By similarity
    Metal bindingi103 – 1031Magnesium 2By similarity
    Metal bindingi105 – 1051Magnesium 1; via carbonyl oxygenBy similarity
    Metal bindingi106 – 1061Magnesium 2By similarity
    Binding sitei226 – 2261SubstrateBy similarity
    Metal bindingi233 – 2331Magnesium 2By similarity
    Binding sitei233 – 2331SubstrateBy similarity

    GO - Molecular functioni

    1. inositol monophosphate 1-phosphatase activity Source: MGI
    2. inositol monophosphate 3-phosphatase activity Source: UniProtKB-EC
    3. inositol monophosphate 4-phosphatase activity Source: UniProtKB-EC
    4. metal ion binding Source: UniProtKB-KW
    5. protein homodimerization activity Source: MGI

    GO - Biological processi

    1. inositol biosynthetic process Source: UniProtKB-UniPathway
    2. inositol metabolic process Source: MGI
    3. inositol phosphate dephosphorylation Source: MGI
    4. phosphatidylinositol phosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Lithium, Magnesium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196478. Synthesis of IP2, IP, and Ins in the cytosol.
    UniPathwayiUPA00823; UER00788.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol monophosphatase 2 (EC:3.1.3.25)
    Short name:
    IMP 2
    Short name:
    IMPase 2
    Alternative name(s):
    Inositol-1(or 4)-monophosphatase 2
    Myo-inositol monophosphatase A2
    Gene namesi
    Name:Impa2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:2149728. Impa2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Inositol monophosphatase 2PRO_0000142521Add
    BLAST

    Proteomic databases

    MaxQBiQ91UZ5.
    PaxDbiQ91UZ5.
    PRIDEiQ91UZ5.

    PTM databases

    PhosphoSiteiQ91UZ5.

    Expressioni

    Tissue specificityi

    Mostly expressed in brain, small intestine, heart, kidney, and spleen (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ91UZ5.
    BgeeiQ91UZ5.
    CleanExiMM_IMPA2.
    GenevestigatoriQ91UZ5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91UZ5.
    SMRiQ91UZ5. Positions 17-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni105 – 1084Substrate bindingBy similarity
    Regioni207 – 2093Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the inositol monophosphatase family.Curated

    Phylogenomic databases

    eggNOGiCOG0483.
    GeneTreeiENSGT00390000014699.
    HOVERGENiHBG052123.
    InParanoidiQ91UZ5.
    KOiK01092.
    OMAiREMAMFI.
    OrthoDBiEOG7RJPS8.
    PhylomeDBiQ91UZ5.
    TreeFamiTF313194.

    Family and domain databases

    InterProiIPR020583. Inositol_monoP_metal-BS.
    IPR020552. Inositol_monoPase_Li-sen.
    IPR000760. Inositol_monophosphatase.
    IPR020550. Inositol_monophosphatase_CS.
    [Graphical view]
    PANTHERiPTHR20854. PTHR20854. 1 hit.
    PfamiPF00459. Inositol_P. 1 hit.
    [Graphical view]
    PRINTSiPR00377. IMPHPHTASES.
    PR00378. LIIMPHPHTASE.
    PROSITEiPS00629. IMP_1. 1 hit.
    PS00630. IMP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91UZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPSSEEEGE LVQGVGPWDE CFEVAVQLAL RAGQIIRKAL TEEKRVSTKT    50
    SAADLVTETD HRVEDLIVSE LRKRFPSHRF IAEEATASGA KCVLTHSPTW 100
    IIDPIDGTCN FVHRFPTVAV SIGFAVHQEL EFGVIHHCTE ERLYTGRRGQ 150
    GAFCNGQRLQ VSRETDLAKA LVLTEIGPKR DPDTLKVFLS NMERLLHAKA 200
    HGVRVIGSST LALCYLASGA ADAYYQFGLH CWDLAAATVI IREAGGIVID 250
    TSGGPLDLMS CRVVAAGTRE MAVLIAQALQ TINYGRDDEK 290
    Length:290
    Mass (Da):31,716
    Last modified:December 1, 2001 - v1
    Checksum:iF27FDC7EB1D5A436
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF353730 mRNA. Translation: AAK39516.1.
    BC011093 mRNA. Translation: AAH11093.1.
    CCDSiCCDS29320.1.
    RefSeqiNP_444491.1. NM_053261.2.
    UniGeneiMm.34079.
    Mm.486871.

    Genome annotation databases

    EnsembliENSMUST00000025403; ENSMUSP00000025403; ENSMUSG00000024525.
    GeneIDi114663.
    KEGGimmu:114663.
    UCSCiuc008fly.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF353730 mRNA. Translation: AAK39516.1 .
    BC011093 mRNA. Translation: AAH11093.1 .
    CCDSi CCDS29320.1.
    RefSeqi NP_444491.1. NM_053261.2.
    UniGenei Mm.34079.
    Mm.486871.

    3D structure databases

    ProteinModelPortali Q91UZ5.
    SMRi Q91UZ5. Positions 17-283.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91UZ5.

    Proteomic databases

    MaxQBi Q91UZ5.
    PaxDbi Q91UZ5.
    PRIDEi Q91UZ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025403 ; ENSMUSP00000025403 ; ENSMUSG00000024525 .
    GeneIDi 114663.
    KEGGi mmu:114663.
    UCSCi uc008fly.1. mouse.

    Organism-specific databases

    CTDi 3613.
    MGIi MGI:2149728. Impa2.

    Phylogenomic databases

    eggNOGi COG0483.
    GeneTreei ENSGT00390000014699.
    HOVERGENi HBG052123.
    InParanoidi Q91UZ5.
    KOi K01092.
    OMAi REMAMFI.
    OrthoDBi EOG7RJPS8.
    PhylomeDBi Q91UZ5.
    TreeFami TF313194.

    Enzyme and pathway databases

    UniPathwayi UPA00823 ; UER00788 .
    Reactomei REACT_196478. Synthesis of IP2, IP, and Ins in the cytosol.

    Miscellaneous databases

    ChiTaRSi IMPA2. mouse.
    NextBioi 368644.
    PROi Q91UZ5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91UZ5.
    Bgeei Q91UZ5.
    CleanExi MM_IMPA2.
    Genevestigatori Q91UZ5.

    Family and domain databases

    InterProi IPR020583. Inositol_monoP_metal-BS.
    IPR020552. Inositol_monoPase_Li-sen.
    IPR000760. Inositol_monophosphatase.
    IPR020550. Inositol_monophosphatase_CS.
    [Graphical view ]
    PANTHERi PTHR20854. PTHR20854. 1 hit.
    Pfami PF00459. Inositol_P. 1 hit.
    [Graphical view ]
    PRINTSi PR00377. IMPHPHTASES.
    PR00378. LIIMPHPHTASE.
    PROSITEi PS00629. IMP_1. 1 hit.
    PS00630. IMP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two genes, Impa1 and Impa2 encoding mouse myo-inositol monophosphatases."
      Shamir A., Sjoeholt G., Ebstein R.P., Agam G., Steen V.M.
      Gene 271:285-291(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    3. "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1."
      Ohnishi T., Ohba H., Seo K.-C., Im J., Sato Y., Iwayama Y., Furuichi T., Chung S.-K., Yoshikawa T.
      J. Biol. Chem. 282:637-646(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiIMPA2_MOUSE
    AccessioniPrimary (citable) accession number: Q91UZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3