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Protein

Inositol monophosphatase 2

Gene

Impa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li+ action in brain (By similarity).By similarity

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactori

Mg2+By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Magnesium 1By similarity
Binding sitei83 – 831SubstrateBy similarity
Metal bindingi103 – 1031Magnesium 1By similarity
Metal bindingi103 – 1031Magnesium 2By similarity
Metal bindingi105 – 1051Magnesium 1; via carbonyl oxygenBy similarity
Metal bindingi106 – 1061Magnesium 2By similarity
Binding sitei226 – 2261SubstrateBy similarity
Metal bindingi233 – 2331Magnesium 2By similarity
Binding sitei233 – 2331SubstrateBy similarity

GO - Molecular functioni

  1. inositol monophosphate 1-phosphatase activity Source: MGI
  2. inositol monophosphate 3-phosphatase activity Source: UniProtKB-EC
  3. inositol monophosphate 4-phosphatase activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW
  5. protein homodimerization activity Source: MGI

GO - Biological processi

  1. inositol biosynthetic process Source: UniProtKB-UniPathway
  2. inositol metabolic process Source: MGI
  3. inositol phosphate dephosphorylation Source: MGI
  4. phosphatidylinositol phosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Lithium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196478. Synthesis of IP2, IP, and Ins in the cytosol.
UniPathwayiUPA00823; UER00788.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol monophosphatase 2 (EC:3.1.3.25)
Short name:
IMP 2
Short name:
IMPase 2
Alternative name(s):
Inositol-1(or 4)-monophosphatase 2
Myo-inositol monophosphatase A2
Gene namesi
Name:Impa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:2149728. Impa2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Inositol monophosphatase 2PRO_0000142521Add
BLAST

Proteomic databases

MaxQBiQ91UZ5.
PaxDbiQ91UZ5.
PRIDEiQ91UZ5.

PTM databases

PhosphoSiteiQ91UZ5.

Expressioni

Tissue specificityi

Mostly expressed in brain, small intestine, heart, kidney, and spleen (at protein level).1 Publication

Gene expression databases

BgeeiQ91UZ5.
CleanExiMM_IMPA2.
ExpressionAtlasiQ91UZ5. baseline and differential.
GenevestigatoriQ91UZ5.

Structurei

3D structure databases

ProteinModelPortaliQ91UZ5.
SMRiQ91UZ5. Positions 17-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni105 – 1084Substrate bindingBy similarity
Regioni207 – 2093Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the inositol monophosphatase family.Curated

Phylogenomic databases

eggNOGiCOG0483.
GeneTreeiENSGT00390000014699.
HOVERGENiHBG052123.
InParanoidiQ91UZ5.
KOiK01092.
OMAiGDPWKEC.
OrthoDBiEOG7RJPS8.
PhylomeDBiQ91UZ5.
TreeFamiTF313194.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR020552. Inositol_monoPase_Li-sen.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR00378. LIIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91UZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPSSEEEGE LVQGVGPWDE CFEVAVQLAL RAGQIIRKAL TEEKRVSTKT
60 70 80 90 100
SAADLVTETD HRVEDLIVSE LRKRFPSHRF IAEEATASGA KCVLTHSPTW
110 120 130 140 150
IIDPIDGTCN FVHRFPTVAV SIGFAVHQEL EFGVIHHCTE ERLYTGRRGQ
160 170 180 190 200
GAFCNGQRLQ VSRETDLAKA LVLTEIGPKR DPDTLKVFLS NMERLLHAKA
210 220 230 240 250
HGVRVIGSST LALCYLASGA ADAYYQFGLH CWDLAAATVI IREAGGIVID
260 270 280 290
TSGGPLDLMS CRVVAAGTRE MAVLIAQALQ TINYGRDDEK
Length:290
Mass (Da):31,716
Last modified:December 1, 2001 - v1
Checksum:iF27FDC7EB1D5A436
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353730 mRNA. Translation: AAK39516.1.
BC011093 mRNA. Translation: AAH11093.1.
CCDSiCCDS29320.1.
RefSeqiNP_444491.1. NM_053261.2.
UniGeneiMm.34079.
Mm.486871.

Genome annotation databases

EnsembliENSMUST00000025403; ENSMUSP00000025403; ENSMUSG00000024525.
GeneIDi114663.
KEGGimmu:114663.
UCSCiuc008fly.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353730 mRNA. Translation: AAK39516.1.
BC011093 mRNA. Translation: AAH11093.1.
CCDSiCCDS29320.1.
RefSeqiNP_444491.1. NM_053261.2.
UniGeneiMm.34079.
Mm.486871.

3D structure databases

ProteinModelPortaliQ91UZ5.
SMRiQ91UZ5. Positions 17-283.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ91UZ5.

Proteomic databases

MaxQBiQ91UZ5.
PaxDbiQ91UZ5.
PRIDEiQ91UZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025403; ENSMUSP00000025403; ENSMUSG00000024525.
GeneIDi114663.
KEGGimmu:114663.
UCSCiuc008fly.1. mouse.

Organism-specific databases

CTDi3613.
MGIiMGI:2149728. Impa2.

Phylogenomic databases

eggNOGiCOG0483.
GeneTreeiENSGT00390000014699.
HOVERGENiHBG052123.
InParanoidiQ91UZ5.
KOiK01092.
OMAiGDPWKEC.
OrthoDBiEOG7RJPS8.
PhylomeDBiQ91UZ5.
TreeFamiTF313194.

Enzyme and pathway databases

UniPathwayiUPA00823; UER00788.
ReactomeiREACT_196478. Synthesis of IP2, IP, and Ins in the cytosol.

Miscellaneous databases

NextBioi368644.
PROiQ91UZ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ91UZ5.
CleanExiMM_IMPA2.
ExpressionAtlasiQ91UZ5. baseline and differential.
GenevestigatoriQ91UZ5.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR020552. Inositol_monoPase_Li-sen.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR00378. LIIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two genes, Impa1 and Impa2 encoding mouse myo-inositol monophosphatases."
    Shamir A., Sjoeholt G., Ebstein R.P., Agam G., Steen V.M.
    Gene 271:285-291(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  3. "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1."
    Ohnishi T., Ohba H., Seo K.-C., Im J., Sato Y., Iwayama Y., Furuichi T., Chung S.-K., Yoshikawa T.
    J. Biol. Chem. 282:637-646(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiIMPA2_MOUSE
AccessioniPrimary (citable) accession number: Q91UZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.