Unreviewed, UniProtKB/TrEMBL Q91UZ1 (Q91UZ1_MOUSE)

Names and origin

Protein names

Submitted name:
    Phospholipase C beta 4 EMBL AAK56100.1
Submitted name:
    Phospholipase C, beta 4 EMBL AAI29884.1
    Plcb4 EMBL AAX90610.1

Gene names

Name:	Plcb4 EMBL AAK56100.1 MGI 107464
ORF Names:	RP23-7A19.1-002 EMBL CAM26951.1

Organism

Mus musculus (Mouse) EMBL AAK56100.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	1175 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain.

Ontologies

Keywords
Molecular function	Transducer Spearmint SPM001192
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro lipid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	dendrite Inferred from direct assay. Source: MGI microsome Inferred from direct assay. Source: MGI nucleus Inferred from direct assay. Source: MGI postsynaptic density Inferred from direct assay. Source: MGI smooth endoplasmic reticulum Inferred from direct assay. Source: MGI
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro phosphoinositide phospholipase C activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: MGI signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q91UZ1-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: FC6919002C512B48	FASTA	1,175	134,528
	10 20 30 40 50 60 MAKPYEFNWQ KEVPSFLQEG AVFDRYEEES FVFEPNCLFK VDEFGFFLTW KSEGKEGQVL 70 80 90 100 110 120 ECSLINSIRQ AAIPKDPKIL AALEAVGKSE NDLEGRILCV CSGTDLVNIG FTYMVAENPE 130 140 150 160 170 180 VTKQWVEGLR SIIHNFRANN VSPMTCLKKH WMKLAFLTNT TGKIPVRSIT RTFASGKTEK 190 200 210 220 230 240 VIFQALKELG LPSGKNDEIE PAAFTYEKFY ELTQKICPRT DIEDLFKKIN GDKTDYLTVD 250 260 270 280 290 300 QLVSFLNEHQ RDPRLNEILF PFYDAKRAMQ IIEMYEPDEE LKKKGLISSD GFCRYLMSDE 310 320 330 340 350 360 NAPVFLDRLE LYQEMDHPLA HYFISSSHNT YLTGRQFGGK SSVEMYRQVL LAGCRCVELD 370 380 390 400 410 420 CWDGKGEDQE PIITHGKAMC TDILFKDVIQ AIKETAFVTS EYPVILSFEN HCSKYQQYKM 430 440 450 460 470 480 SKYCEDLFGD LLLKQALESH PLEPGRPLPS PNDLKRKILI KNKRLKPEVE KKQLEALKSM 490 500 510 520 530 540 MEAGESAAPA SILEDDNEEE IESADQEEEA HPEYKFGNEL SADDYSHKEA VANSVKKGLV 550 560 570 580 590 600 TVEDEQAWMA SYKYVGATTN IHPYLSTMIN YAQPVKFQGF HVAEERNIHY NMSSFNESVG 610 620 630 640 650 660 LGYLKTHAIE FVNYNKRQMS RIYPKGGRVD SSNYMPQIFW NAGCQMVSLN YQTPDLAMQL 670 680 690 700 710 720 NQGKFEYNGS CGYLLKPDFM RRPDRTFDPF SETPVDGVIA ATCSVQVISG QFLSDKKIGT 730 740 750 760 770 780 YVEVDMYGLP TDTIRKEFRT RMVMNNGLNP VYNEESFVFR KVILPDLAVL RIAVYDDNNK 790 800 810 820 830 840 LIGQRILPLD GLQAGYRHIS LRNEGNKPLS LPTIFCNIVL KTYVPDGFGD IVDALSDPKK 850 860 870 880 890 900 FLSITEKRAD QMRAMGIETS DIADVPSDTS KNDKKGKANP AKANVTPQSS SELRPTTTAA 910 920 930 940 950 960 LGSGQEAKKG IELIPQVRIE DLKQMKAYLK HLKKQQKELN SLKKKHAKEH STMQKLHCTQ 970 980 990 1000 1010 1020 VDKIVAQYDK EKSTHEKILE KAMKKKGGSN CLEIKKETEI KIQTLTTDHK SKVKEIVAQH 1030 1040 1050 1060 1070 1080 TKEWSEMINT HSAEEQEIRD LHLSQQCELL RKLLINAHEQ QTQQLKLSHD RESKEMRAHQ 1090 1100 1110 1120 1130 1140 AKISMENSKA ISQDKSIKNK AERERRVREL NSSNTKKFLE ERKRLAMKQS KEMDQLKKVQ 1150 1160 1170 LEHLEFLEKQ NEQAKEMQQM VKLEAEMDRR PATVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"High-throughput sequence identification of gene coding variants within alcohol-related QTLs." Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M. Mamm. Genome 12:657-663(2001) [PubMed: 11471062] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ILS EMBL AAK56100.1 and ISS EMBL AAK56099.1.
[2]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[3]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed: 19144319] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[4]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PCR rescued clones EMBL AAI29884.1.
[6]	Lovell J. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[7]	"Characterization of quantitative trait loci influencing growth and adiposity using congenic mouse strains." Farber C.R., Corva P.M., Medrano J.F. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: CAST/EiJ EMBL AAX90610.1. Tissue: Brain EMBL AAX90610.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC129883 mRNA. Translation: AAI29884.1. AF332071 mRNA. Translation: AAK56099.1. AF332072 mRNA. Translation: AAK56100.1. AY902325 Genomic DNA. Translation: AAX90610.1. AL928798 Genomic DNA. Translation: CAM26951.1.
IPI	IPI00625848.
RefSeq	NP_038857.1.
UniGene	Mm.38009
3D structure databases
HSSP	HSSP built from PDB template 1DJX based on UniProtKB P10688.
SMR	Q91UZ1. Positions 12-821.
ModBase	Search...
Protein-protein interaction databases
STRING	Q91UZ1.
PTM databases
PhosphoSite	Q91UZ1.
Proteomic databases
PRIDE	Q91UZ1.
Genome annotation databases
Ensembl	ENSMUST00000035646; ENSMUSP00000038409; ENSMUSG00000039943; Mus musculus. [Genome view] ENSMUST00000110109; ENSMUSP00000105736; ENSMUSG00000039943; Mus musculus. [Genome view]
GeneID	18798.
KEGG	mmu:18798.
UCSC	uc008mod.1. mouse.
Organism-specific databases
CTD	18798.
MGI	MGI:107464. Plcb4.
Phylogenomic databases
HOGENOM	HBG315986.
HOVERGEN	Q91UZ1.
InParanoid	Q91UZ1.
OMA	FLTWRSE.
OrthoDB	EOG9H48PG.
PhylomeDB	Q91UZ1.
Gene expression databases
ArrayExpress	Q91UZ1.
Bgee	Q91UZ1.
Genevestigator	Q91UZ1.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR011992. EF-hand-like_dom. IPR015359. Phospholipase_C_EF-hand-like. IPR001192. Phospholipase_C_Pinositol-sp_C. IPR001711. Phospholipase_C_Pinositol-sp_Y. IPR016280. PLC-beta. IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR000909. PLipase_C_PInositol-sp_X_dom. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit. G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 1 hit.
Pfam	PF00168. C2. 1 hit. PF09279. efhand_like. 1 hit. PF00388. PI-PLC-X. 1 hit. PF00387. PI-PLC-Y. 1 hit. [Graphical view]
PIRSF	PIRSF000956. PLC-beta. 1 hit.
PRINTS	PR00390. PHPHLIPASEC.
SMART	SM00239. C2. 1 hit. SM00148. PLCXc. 1 hit. SM00149. PLCYc. 1 hit. [Graphical view]
PROSITE	PS50004. C2. 1 hit. PS50007. PIPLC_X_DOMAIN. 1 hit. PS50008. PIPLC_Y_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	295092.
SOURCE	Search...

Entry information

Entry name

Q91UZ1_MOUSE

Accession

Primary (citable) accession number: Q91UZ1

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	February 9, 2010
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)