Phospholipase C beta 4 - Mus musculus (Mouse)

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Unreviewed, UniProtKB/TrEMBL Q91UZ1 (Q91UZ1_MOUSE)

Last modified February 9, 2010. Version 67. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
    Phospholipase C beta 4 EMBL AAK56100.1
Submitted name:
    Phospholipase C, beta 4 EMBL AAI29884.1
    Plcb4 EMBL AAX90610.1

Gene names

Name:	Plcb4 EMBL AAK56100.1 MGI 107464
ORF Names:	RP23-7A19.1-002 EMBL CAM26951.1

Organism

Mus musculus (Mouse) EMBL AAK56100.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	1175 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Sequence similarities

Contains 1 C2 domain.

Contains 1 PI-PLC X-box domain.

Contains 1 PI-PLC Y-box domain.

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Ontologies

Keywords
Molecular function	Transducer Spearmint SPM001192
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro lipid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	dendrite Inferred from direct assay. Source: MGI microsome Inferred from direct assay. Source: MGI nucleus Inferred from direct assay. Source: MGI postsynaptic density Inferred from direct assay. Source: MGI smooth endoplasmic reticulum Inferred from direct assay. Source: MGI
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro phosphoinositide phospholipase C activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: MGI signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q91UZ1-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: FC6919002C512B48
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FASTA

1,175

134,528

        10         20         30         40         50         60 
MAKPYEFNWQ KEVPSFLQEG AVFDRYEEES FVFEPNCLFK VDEFGFFLTW KSEGKEGQVL 

        70         80         90        100        110        120 
ECSLINSIRQ AAIPKDPKIL AALEAVGKSE NDLEGRILCV CSGTDLVNIG FTYMVAENPE 

       130        140        150        160        170        180 
VTKQWVEGLR SIIHNFRANN VSPMTCLKKH WMKLAFLTNT TGKIPVRSIT RTFASGKTEK 

       190        200        210        220        230        240 
VIFQALKELG LPSGKNDEIE PAAFTYEKFY ELTQKICPRT DIEDLFKKIN GDKTDYLTVD 

       250        260        270        280        290        300 
QLVSFLNEHQ RDPRLNEILF PFYDAKRAMQ IIEMYEPDEE LKKKGLISSD GFCRYLMSDE 

       310        320        330        340        350        360 
NAPVFLDRLE LYQEMDHPLA HYFISSSHNT YLTGRQFGGK SSVEMYRQVL LAGCRCVELD 

       370        380        390        400        410        420 
CWDGKGEDQE PIITHGKAMC TDILFKDVIQ AIKETAFVTS EYPVILSFEN HCSKYQQYKM 

       430        440        450        460        470        480 
SKYCEDLFGD LLLKQALESH PLEPGRPLPS PNDLKRKILI KNKRLKPEVE KKQLEALKSM 

       490        500        510        520        530        540 
MEAGESAAPA SILEDDNEEE IESADQEEEA HPEYKFGNEL SADDYSHKEA VANSVKKGLV 

       550        560        570        580        590        600 
TVEDEQAWMA SYKYVGATTN IHPYLSTMIN YAQPVKFQGF HVAEERNIHY NMSSFNESVG 

       610        620        630        640        650        660 
LGYLKTHAIE FVNYNKRQMS RIYPKGGRVD SSNYMPQIFW NAGCQMVSLN YQTPDLAMQL 

       670        680        690        700        710        720 
NQGKFEYNGS CGYLLKPDFM RRPDRTFDPF SETPVDGVIA ATCSVQVISG QFLSDKKIGT 

       730        740        750        760        770        780 
YVEVDMYGLP TDTIRKEFRT RMVMNNGLNP VYNEESFVFR KVILPDLAVL RIAVYDDNNK 

       790        800        810        820        830        840 
LIGQRILPLD GLQAGYRHIS LRNEGNKPLS LPTIFCNIVL KTYVPDGFGD IVDALSDPKK 

       850        860        870        880        890        900 
FLSITEKRAD QMRAMGIETS DIADVPSDTS KNDKKGKANP AKANVTPQSS SELRPTTTAA 

       910        920        930        940        950        960 
LGSGQEAKKG IELIPQVRIE DLKQMKAYLK HLKKQQKELN SLKKKHAKEH STMQKLHCTQ 

       970        980        990       1000       1010       1020 
VDKIVAQYDK EKSTHEKILE KAMKKKGGSN CLEIKKETEI KIQTLTTDHK SKVKEIVAQH 

      1030       1040       1050       1060       1070       1080 
TKEWSEMINT HSAEEQEIRD LHLSQQCELL RKLLINAHEQ QTQQLKLSHD RESKEMRAHQ 

      1090       1100       1110       1120       1130       1140 
AKISMENSKA ISQDKSIKNK AERERRVREL NSSNTKKFLE ERKRLAMKQS KEMDQLKKVQ 

      1150       1160       1170 
LEHLEFLEKQ NEQAKEMQQM VKLEAEMDRR PATVV

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"High-throughput sequence identification of gene coding variants within alcohol-related QTLs." Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M. Mamm. Genome 12:657-663(2001) [PubMed: 11471062] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ILS EMBL AAK56100.1 and ISS EMBL AAK56099.1.
[2]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[3]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed: 19144319] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[4]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PCR rescued clones EMBL AAI29884.1.
[6]	Lovell J. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[7]	"Characterization of quantitative trait loci influencing growth and adiposity using congenic mouse strains." Farber C.R., Corva P.M., Medrano J.F. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: CAST/EiJ EMBL AAX90610.1. Tissue: Brain EMBL AAX90610.1.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	BC129883 mRNA. Translation: AAI29884.1. AF332071 mRNA. Translation: AAK56099.1. AF332072 mRNA. Translation: AAK56100.1. AY902325 Genomic DNA. Translation: AAX90610.1. AL928798 Genomic DNA. Translation: CAM26951.1.
IPI	IPI00625848.
RefSeq	NP_038857.1.
UniGene	Mm.38009
3D structure databases
HSSP	HSSP built from PDB template 1DJX based on UniProtKB P10688.
SMR	Q91UZ1. Positions 12-821.
ModBase	Search...
Protein-protein interaction databases
STRING	Q91UZ1.
PTM databases
PhosphoSite	Q91UZ1.
Proteomic databases
PRIDE	Q91UZ1.
Genome annotation databases
Ensembl	ENSMUST00000035646; ENSMUSP00000038409; ENSMUSG00000039943; Mus musculus. [Genome view] ENSMUST00000110109; ENSMUSP00000105736; ENSMUSG00000039943; Mus musculus. [Genome view]
GeneID	18798.
KEGG	mmu:18798.
UCSC	uc008mod.1. mouse.
Organism-specific databases
CTD	18798.
MGI	MGI:107464. Plcb4.
Phylogenomic databases
HOGENOM	HBG315986.
HOVERGEN	Q91UZ1.
InParanoid	Q91UZ1.
OMA	FLTWRSE.
OrthoDB	EOG9H48PG.
PhylomeDB	Q91UZ1.
Gene expression databases
ArrayExpress	Q91UZ1.
Bgee	Q91UZ1.
Genevestigator	Q91UZ1.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR011992. EF-hand-like_dom. IPR015359. Phospholipase_C_EF-hand-like. IPR001192. Phospholipase_C_Pinositol-sp_C. IPR001711. Phospholipase_C_Pinositol-sp_Y. IPR016280. PLC-beta. IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR000909. PLipase_C_PInositol-sp_X_dom. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit. G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 1 hit.
Pfam	PF00168. C2. 1 hit. PF09279. efhand_like. 1 hit. PF00388. PI-PLC-X. 1 hit. PF00387. PI-PLC-Y. 1 hit. [Graphical view]
PIRSF	PIRSF000956. PLC-beta. 1 hit.
PRINTS	PR00390. PHPHLIPASEC.
SMART	SM00239. C2. 1 hit. SM00148. PLCXc. 1 hit. SM00149. PLCYc. 1 hit. [Graphical view]
PROSITE	PS50004. C2. 1 hit. PS50007. PIPLC_X_DOMAIN. 1 hit. PS50008. PIPLC_Y_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	295092.
SOURCE	Search...

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Entry information

Entry name

Q91UZ1_MOUSE

Accession

Primary (citable) accession number: Q91UZ1

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	February 9, 2010
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information