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Protein
Submitted name:

NS3 protease

Gene
N/A
Organism
Hepatitis C virus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi97ZincCombined sources1
Metal bindingi99ZincCombined sources1
Metal bindingi145ZincCombined sources1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • serine-type peptidase activity Source: CACAO

GO - Biological processi

  • self proteolysis Source: CACAO
  • transformation of host cell by virus Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, ProteaseImported

Keywords - Ligandi

Metal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
NS3 proteaseImported
OrganismiHepatitis C virusImported
Taxonomic identifieri11103 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus

Pathology & Biotechi

Chemistry databases

DrugBankiDB06290. Simeprevir.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 145Combined sources
Disulfide bondi97 ↔ 99Combined sources
Disulfide bondi99 ↔ 145Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A4QX-ray2.45A/C1-181[»]
2F9UX-ray2.60A/C1-181[»]
2OBOX-ray2.60A/C1-181[»]
2P59X-ray2.90A/B1-181[»]
2XCNX-ray3.02A/B1-180[»]
ProteinModelPortaliQ91RS4.
SMRiQ91RS4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91RS4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 177Peptidase_S29InterPro annotationAdd BLAST148

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR004109. Peptidase_S29.
[Graphical view]
PfamiPF02907. Peptidase_S29. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q91RS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
APITAYAQQT RGLLGCIITS LTGRDKNQVE GEVQIVSTAA QTFLATCING
60 70 80 90 100
VCWTVYHGAG TRTIASPKGP VIQMYTNVDQ DLVGWPAPQG ARSLTPCTCG
110 120 130 140 150
SSDLYLVTRH ADVIPVRRRG DSRGSLLSPR PISYLKGSSG GPLLCPAGHA
160 170 180
VGLFRAAVCT RGVAKAVDFI PVENLETTMR S
Length:181
Mass (Da):19,114
Last modified:December 1, 2001 - v1
Checksum:i574AC47AEDFEB0D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei181Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF369229 Genomic RNA. Translation: AAK54554.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF369229 Genomic RNA. Translation: AAK54554.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A4QX-ray2.45A/C1-181[»]
2F9UX-ray2.60A/C1-181[»]
2OBOX-ray2.60A/C1-181[»]
2P59X-ray2.90A/B1-181[»]
2XCNX-ray3.02A/B1-180[»]
ProteinModelPortaliQ91RS4.
SMRiQ91RS4.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB06290. Simeprevir.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

euHCVdbiAF369229.

Miscellaneous databases

EvolutionaryTraceiQ91RS4.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR004109. Peptidase_S29.
[Graphical view]
PfamiPF02907. Peptidase_S29. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ91RS4_9HEPC
AccessioniPrimary (citable) accession number: Q91RS4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.