SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q91RA4

- LMBD2_REOVJ

UniProt

Q91RA4 - LMBD2_REOVJ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Outer capsid protein lambda-2
Gene
L2
Organism
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Outer capsid protein involved in mRNA capping. Catalyzes the last 3 enzymatic activities for formation of the 5' cap structure on the viral plus-strand transcripts, namely the RNA guanylyltransferase, RNA-7N- and RNA-2'O-methyltransferase activities By similarity.

Catalytic activityi

GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.
S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei190 – 1901Involved in formation of the phosphoamide bond By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi892 – 8998ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. mRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-EC
  4. mRNA guanylyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

mRNA capping, mRNA processing

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Outer capsid protein lambda-2
Short name:
Lambda2
Alternative name(s):
Lambda2(Cap)
Including the following 2 domains:
mRNA guanylyltransferase (EC:2.7.7.50)
mRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.56)
Gene namesi
Name:L2
OrganismiReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Taxonomic identifieri10885 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000006370: Genome

Subcellular locationi

Virion Reviewed prediction

GO - Cellular componenti

  1. viral outer capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Outer capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12881288Outer capsid protein lambda-2
PRO_0000344999Add
BLAST

Interactioni

Subunit structurei

Interacts with protein mu-NS; in viral inclusions By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ91RA4.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 1844Poly-Asp
Compositional biasi893 – 8964Poly-Ala

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR010311. Reovirus_L2.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF06016. Reovirus_L2. 1 hit.
[Graphical view]
PIRSFiPIRSF000845. Reovirus_L2. 1 hit.
ProDomiPD149122. Reovirus_L2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q91RA4-1 [UniParc]FASTAAdd to Basket

« Hide

MANVWGVRLA DSLSSPTLES RNRSYTLHDF CSDLDASAGK EPWKALRNQR     50
TSEIVAVRLF RPLQGLILDT HMYGFPGEFD AWEVFVKEKL RVLKYEVLRV 100
YPISGYSNSH VNVFVANALV GAFLSNQAFY DLLPLLIIND TMINDLLGAG 150
VSLAQFFQAH GDVLEVAAGR KYIQMNGYSN DDDDPPLFAK DLSDYAKAFY 200
CESFEVLDRF FWTHDASAGV LVHYDKPTNG NHYLLGTLTQ MVSAPPFIIN 250
ATDAMMLESC VEQFAANAAA RPAQPATRLD QCYHLRWGAQ YVGEDSLTYR 300
LGVLSLLATN GYQLARPIPK QLTNRWLSSF VSQIMSEGAN ETPLWPQERY 350
VQIAYDSPSV VDGAVQYGYV RKNQLRLGMR ISPIQSLSDV PAPVAWLPQY 400
TIDQTALEDG DMVGHMSQLP LRPEYGSMWV GEALSYYVDY NQSHRVVAAK 450
ELPQLPDTYF DGDEQYGRSL FSLARRIGDR SLIKDTAVLK HAYQAIDPST 500
GREYLRAGQS VAYFGASAGH SGADQPLVIE PWLQGKISGV PSPASIRQFG 550
YDVAKGAIVD LARPFPSGDY QFVYSDVDQV VDGHDDLSIS SNLVESILSS 600
CMQATSPGGS FVAKINFPTR SIWYYIEQKI LPNITSYMII KPFVTNNVEV 650
FFVAFGVHRQ SSLTWTSGVY FFLVDHFYRY ETLSAISRQL PSYGYVDDGS 700
SVTGLEVISI ENPGFSTMTQ ASRVAISALC ANTGNSRKTI SIYESHGARV 750
LMLVSRRSPA SAKRKARLRY LPLIDPRSLE VQSRTIMPST PVLFENSNGA 800
SPHVCLTMMY NYEVSSAVYD GDVVLDLGTG PEAKILELIP PTSPATCVDI 850
RPTAQPTGCW NVRTTFLQLD YLSDGWITGV RGDIVTCMLS LGAAAAGKSM 900
TFDAAFQQFV RVIAQSAANV VLVQVNCPTD VIRSVRGYLE IDQTSKRYRF 950
PKFGRDEPYS DMESLERICR ATWPNCSITW VPLSYDLRWT RLALLEAATL 1000
NSASIRIAEL MYKYMPVMRV DIHGLPMNKS GNFVVGQNCS LTIPGFNAQD 1050
TFNCYYNSAL AFSTEDVNAA MIPSVTATFD NAKNEWTLDM VFSDAGIYTM 1100
QAVVGVNASP IALGSFVVDS PDVDITDAWP AQLDFTIAGT DVDITVNPYY 1150
RLMAFVKIDG QWQIANPDKF QFFASATGTL TMNVKLDIAD KYLLYYIRDV 1200
QSREVGFYIQ HPLQLLNTIT LPTNEDLFLS APDMREWAVK ESGNTICILN 1250
SQGFIPPQDW DVLTDTISWS PSLPTYVVPP GDYTLTPL 1288
Length:1,288
Mass (Da):143,152
Last modified:December 1, 2001 - v1
Checksum:iDD4BC3C1488AA137
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378005 mRNA. Translation: AAK57509.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378005 mRNA. Translation: AAK57509.1 .

3D structure databases

ProteinModelPortali Q91RA4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.40.50.150. 1 hit.
InterProi IPR013783. Ig-like_fold.
IPR010311. Reovirus_L2.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF06016. Reovirus_L2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000845. Reovirus_L2. 1 hit.
ProDomi PD149122. Reovirus_L2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Mammalian reovirus L2 gene and lambda2 core spike protein sequences and whole-genome comparisons of reoviruses type 1 Lang, type 2 Jones, and type 3 Dearing."
    Breun L.A., Broering T.J., McCutcheon A.M., Harrison S.J., Luongo C.L., Nibert M.L.
    Virology 287:333-348(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiLMBD2_REOVJ
AccessioniPrimary (citable) accession number: Q91RA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi