Q91PK4 (MU2_REOVJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Microtubule-associated protein mu-2
Short name=Mu2

Gene names

Name:

M1

Organism

Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) [Complete proteome]

Taxonomic identifier

10885 [NCBI]

Taxonomic lineage

Viruses › dsRNA viruses › Reoviridae › Spinareovirinae › Orthoreovirus › Mammalian orthoreovirus › Mammalian orthoreovirus 2

Virus host

Mammalia [TaxID: 40674]

Protein attributes

Sequence length	736 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Minor inner capsid (core) component. Displays NTPase and RNA 5'-triphosphatase (RTPase) activities. ATP is the preferred substrate for hydrolysis. May function as a cofactor of polymerase lambda-3. Associates with microtubules and plays a role in the formation, structural organization and morphology of viral inclusions, where the assembly of cores and the replication of viral RNA occur. Together with mu-NS, recruits the other core proteins to these inclusions By similarity.
Cofactor	Divalent cations By similarity.
Subunit structure	Interacts with protein mu-NS; in viral inclusions. Interacts with polymerase lambda-3; this interaction stimulates the ATPase activity of mu-2 By similarity.
Subcellular location	Virion Potential. Host cytoplasm › host cytoskeleton By similarity. Note: Found in the inner capsid (12 copies). Associates with microtubules By similarity.
Sequence similarities	Belongs to the orthoreovirus mu-2 protein family.

Ontologies

Keywords
Biological process	Host-virus interaction Inhibition of host IRF9 by virus Inhibition of host innate immune response by virus Inhibition of host interferon signaling pathway by virus Viral immunoevasion
Cellular component	Host cytoplasm Host cytoskeleton Virion
Molecular function	Capsid protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	suppression by virus of host IRF9 activity Inferred from electronic annotation. Source: UniProtKB-KW suppression by virus of host type I interferon-mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW host cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 736	736	Microtubule-associated protein mu-2		PRO_0000345001

Sequences

	Sequence		Length	Mass (Da)
	Q91PK4 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: C200281480E2FAA7	FASTA	736	84,004
	10 20 30 40 50 60 MAYVAVPAVV DSRSSEAIGL LESFGVTATK EESDVQYQDH DYVLDQLQYM LDGYEAGDVI 70 80 90 100 110 120 DALVYRNWLH ESVYCLLPPK SQLLEYWKSN PAVIPESVDR RLRKRLMMKK DLRKDDEYNQ 130 140 150 160 170 180 LVRAFKLSDV YTPLVSSSTS PMTMIQSINQ NQIVYSTTDR VIGARISLYA PRKYYSATLS 190 200 210 220 230 240 FTLNRCIIPY GKNVAPIGHA RFNIGTFPSL ASPKCFVLSS VDIESIPNEF IKLFYQRVRS 250 260 270 280 290 300 VHANILNDIS PQLLSDMLQR KRLRVSSPNE RKIAQIMHLP YHVKRGATHV DVYRVDVVDV 310 320 330 340 350 360 LFEVVDIKDG LRSVSRKLTL QTVPVSVIEL IGLETADYCI RKENGMFTDW FLLLTMLSDG 370 380 390 400 410 420 LIDRRTHSQY LINPSSIPPD VIINIYVSGF TNRRVIDVMP EMYDFVKPIG AVLPKGSFKS 430 440 450 460 470 480 TIMRVLDEME VLGVRIMPRC HVVDSDEVGE RMQPTFEHAV MEIYKGIAGV DSLEELINWV 490 500 510 520 530 540 LGPDLIPHDE RLGKLYQSFL PLAKDLLAPV ARHFYEESLS EGRLLTFAHA DSELLNANYF 550 560 570 580 590 600 GHLLRLKIPF ITEVNLMIRK NREGGELFQL VLSYLYKMYA TSAQPMWFGS LLRLMICPWL 610 620 630 640 650 660 HMEKLIGDAD AAITSAEVGW HIPKEHLMQD GWCGCEDGFI TYVVIRAPKL VLEELREKNW 670 680 690 700 710 720 GQYHAQVIVT DRLEVGEPRR VHARVVIKGN HMPSKLISRY ACFSLTMRYM MHLTCGHSIG 730 RSSAYGARLV FRSSLA

References

[1]	"Sequence analysis of the reovirus Type 2 Jones M1 gene." Yin P., Keirstead N.D., Coombs K.M. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF124519 Genomic RNA. Translation: AAK54467.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR012494. Reovirus_Mu2. [Graphical view]
Pfam	PF07781. Reovirus_Mu2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MU2_REOVJ

Accession

Primary (citable) accession number: Q91PK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	December 1, 2001
Last modified:	October 3, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program