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Q91PK4

- MU2_REOVJ

UniProt

Q91PK4 - MU2_REOVJ

Protein

Microtubule-associated protein mu-2

Gene

M1

Organism
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Minor inner capsid (core) component. Displays NTPase and RNA 5'-triphosphatase (RTPase) activities. ATP is the preferred substrate for hydrolysis. May function as a cofactor of polymerase lambda-3. Associates with microtubules and plays a role in the formation, structural organization and morphology of viral inclusions, where the assembly of cores and the replication of viral RNA occur. Together with mu-NS, recruits the other core proteins to these inclusions By similarity.By similarity

    Cofactori

    Divalent cations.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. suppression by virus of host IRF9 activity Source: UniProtKB-KW
    2. suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host IRF9 by virus, Viral immunoevasion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microtubule-associated protein mu-2
    Short name:
    Mu2
    Gene namesi
    Name:M1
    OrganismiReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
    Taxonomic identifieri10885 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
    Virus hostiMammalia [TaxID: 40674]
    ProteomesiUP000006370: Genome

    Subcellular locationi

    Virion Curated. Host cytoplasmhost cytoskeleton By similarity
    Note: Found in the inner capsid (12 copies). Associates with microtubules By similarity.By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-KW
    2. host cytoskeleton Source: UniProtKB-SubCell
    3. viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host cytoplasm, Host cytoskeleton, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 736736Microtubule-associated protein mu-2PRO_0000345001Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with protein mu-NS; in viral inclusions. Interacts with polymerase lambda-3; this interaction stimulates the ATPase activity of mu-2 By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the orthoreovirus mu-2 protein family.Curated

    Family and domain databases

    InterProiIPR012494. Reovirus_Mu2.
    [Graphical view]
    PfamiPF07781. Reovirus_Mu2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91PK4-1 [UniParc]FASTAAdd to Basket

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    MAYVAVPAVV DSRSSEAIGL LESFGVTATK EESDVQYQDH DYVLDQLQYM    50
    LDGYEAGDVI DALVYRNWLH ESVYCLLPPK SQLLEYWKSN PAVIPESVDR 100
    RLRKRLMMKK DLRKDDEYNQ LVRAFKLSDV YTPLVSSSTS PMTMIQSINQ 150
    NQIVYSTTDR VIGARISLYA PRKYYSATLS FTLNRCIIPY GKNVAPIGHA 200
    RFNIGTFPSL ASPKCFVLSS VDIESIPNEF IKLFYQRVRS VHANILNDIS 250
    PQLLSDMLQR KRLRVSSPNE RKIAQIMHLP YHVKRGATHV DVYRVDVVDV 300
    LFEVVDIKDG LRSVSRKLTL QTVPVSVIEL IGLETADYCI RKENGMFTDW 350
    FLLLTMLSDG LIDRRTHSQY LINPSSIPPD VIINIYVSGF TNRRVIDVMP 400
    EMYDFVKPIG AVLPKGSFKS TIMRVLDEME VLGVRIMPRC HVVDSDEVGE 450
    RMQPTFEHAV MEIYKGIAGV DSLEELINWV LGPDLIPHDE RLGKLYQSFL 500
    PLAKDLLAPV ARHFYEESLS EGRLLTFAHA DSELLNANYF GHLLRLKIPF 550
    ITEVNLMIRK NREGGELFQL VLSYLYKMYA TSAQPMWFGS LLRLMICPWL 600
    HMEKLIGDAD AAITSAEVGW HIPKEHLMQD GWCGCEDGFI TYVVIRAPKL 650
    VLEELREKNW GQYHAQVIVT DRLEVGEPRR VHARVVIKGN HMPSKLISRY 700
    ACFSLTMRYM MHLTCGHSIG RSSAYGARLV FRSSLA 736
    Length:736
    Mass (Da):84,004
    Last modified:December 1, 2001 - v1
    Checksum:iC200281480E2FAA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124519 Genomic RNA. Translation: AAK54467.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124519 Genomic RNA. Translation: AAK54467.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR012494. Reovirus_Mu2.
    [Graphical view ]
    Pfami PF07781. Reovirus_Mu2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the reovirus Type 2 Jones M1 gene."
      Yin P., Keirstead N.D., Coombs K.M.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiMU2_REOVJ
    AccessioniPrimary (citable) accession number: Q91PK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3