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Q91PK4 (MU2_REOVJ) Reviewed, UniProtKB/Swiss-Prot

Last modified October 3, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Microtubule-associated protein mu-2

Short name=Mu2
Gene names
Name:M1
OrganismReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) [Complete proteome]
Taxonomic identifier10885 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostMammalia [TaxID: 40674]

Protein attributes

Sequence length736 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Minor inner capsid (core) component. Displays NTPase and RNA 5'-triphosphatase (RTPase) activities. ATP is the preferred substrate for hydrolysis. May function as a cofactor of polymerase lambda-3. Associates with microtubules and plays a role in the formation, structural organization and morphology of viral inclusions, where the assembly of cores and the replication of viral RNA occur. Together with mu-NS, recruits the other core proteins to these inclusions By similarity.

Cofactor

Divalent cations By similarity.

Subunit structure

Interacts with protein mu-NS; in viral inclusions. Interacts with polymerase lambda-3; this interaction stimulates the ATPase activity of mu-2 By similarity.

Subcellular location

Virion Potential. Host cytoplasmhost cytoskeleton By similarity. Note: Found in the inner capsid (12 copies). Associates with microtubules By similarity.

Sequence similarities

Belongs to the orthoreovirus mu-2 protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 736736Microtubule-associated protein mu-2
PRO_0000345001

Sequences

Sequence LengthMass (Da)Tools
Q91PK4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: C200281480E2FAA7

FASTA73684,004
        10         20         30         40         50         60 
MAYVAVPAVV DSRSSEAIGL LESFGVTATK EESDVQYQDH DYVLDQLQYM LDGYEAGDVI 

        70         80         90        100        110        120 
DALVYRNWLH ESVYCLLPPK SQLLEYWKSN PAVIPESVDR RLRKRLMMKK DLRKDDEYNQ 

       130        140        150        160        170        180 
LVRAFKLSDV YTPLVSSSTS PMTMIQSINQ NQIVYSTTDR VIGARISLYA PRKYYSATLS 

       190        200        210        220        230        240 
FTLNRCIIPY GKNVAPIGHA RFNIGTFPSL ASPKCFVLSS VDIESIPNEF IKLFYQRVRS 

       250        260        270        280        290        300 
VHANILNDIS PQLLSDMLQR KRLRVSSPNE RKIAQIMHLP YHVKRGATHV DVYRVDVVDV 

       310        320        330        340        350        360 
LFEVVDIKDG LRSVSRKLTL QTVPVSVIEL IGLETADYCI RKENGMFTDW FLLLTMLSDG 

       370        380        390        400        410        420 
LIDRRTHSQY LINPSSIPPD VIINIYVSGF TNRRVIDVMP EMYDFVKPIG AVLPKGSFKS 

       430        440        450        460        470        480 
TIMRVLDEME VLGVRIMPRC HVVDSDEVGE RMQPTFEHAV MEIYKGIAGV DSLEELINWV 

       490        500        510        520        530        540 
LGPDLIPHDE RLGKLYQSFL PLAKDLLAPV ARHFYEESLS EGRLLTFAHA DSELLNANYF 

       550        560        570        580        590        600 
GHLLRLKIPF ITEVNLMIRK NREGGELFQL VLSYLYKMYA TSAQPMWFGS LLRLMICPWL 

       610        620        630        640        650        660 
HMEKLIGDAD AAITSAEVGW HIPKEHLMQD GWCGCEDGFI TYVVIRAPKL VLEELREKNW 

       670        680        690        700        710        720 
GQYHAQVIVT DRLEVGEPRR VHARVVIKGN HMPSKLISRY ACFSLTMRYM MHLTCGHSIG 

       730 
RSSAYGARLV FRSSLA 

« Hide

References

[1]"Sequence analysis of the reovirus Type 2 Jones M1 gene."
Yin P., Keirstead N.D., Coombs K.M.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF124519 Genomic RNA. Translation: AAK54467.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR012494. Reovirus_Mu2.
[Graphical view]
PfamPF07781. Reovirus_Mu2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMU2_REOVJ
AccessionPrimary (citable) accession number: Q91PK4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 1, 2001
Last modified: October 3, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families