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Q91PK4

- MU2_REOVJ

UniProt

Q91PK4 - MU2_REOVJ

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Protein

Microtubule-associated protein mu-2

Gene

M1

Organism
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Minor inner capsid (core) component. Displays NTPase and RNA 5'-triphosphatase (RTPase) activities. ATP is the preferred substrate for hydrolysis. May function as a cofactor of polymerase lambda-3. Associates with microtubules and plays a role in the formation, structural organization and morphology of viral inclusions, where the assembly of cores and the replication of viral RNA occur. Together with mu-NS, recruits the other core proteins to these inclusions (By similarity).By similarity

Cofactori

Divalent cations.By similarity

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. suppression by virus of host IRF9 activity Source: UniProtKB-KW
  2. suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host IRF9 by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein mu-2
Short name:
Mu2
Gene namesi
Name:M1
OrganismiReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Taxonomic identifieri10885 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000006370: Genome

Subcellular locationi

Virion Curated. Host cytoplasmhost cytoskeleton By similarity
Note: Found in the inner capsid (12 copies). Associates with microtubules (By similarity).By similarity

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. host cytoskeleton Source: UniProtKB-KW
  3. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, Host cytoskeleton, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736Microtubule-associated protein mu-2PRO_0000345001Add
BLAST

Interactioni

Subunit structurei

Interacts with protein mu-NS; in viral inclusions. Interacts with polymerase lambda-3; this interaction stimulates the ATPase activity of mu-2 (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the orthoreovirus mu-2 protein family.Curated

Family and domain databases

InterProiIPR012494. Reovirus_Mu2.
[Graphical view]
PfamiPF07781. Reovirus_Mu2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91PK4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYVAVPAVV DSRSSEAIGL LESFGVTATK EESDVQYQDH DYVLDQLQYM
60 70 80 90 100
LDGYEAGDVI DALVYRNWLH ESVYCLLPPK SQLLEYWKSN PAVIPESVDR
110 120 130 140 150
RLRKRLMMKK DLRKDDEYNQ LVRAFKLSDV YTPLVSSSTS PMTMIQSINQ
160 170 180 190 200
NQIVYSTTDR VIGARISLYA PRKYYSATLS FTLNRCIIPY GKNVAPIGHA
210 220 230 240 250
RFNIGTFPSL ASPKCFVLSS VDIESIPNEF IKLFYQRVRS VHANILNDIS
260 270 280 290 300
PQLLSDMLQR KRLRVSSPNE RKIAQIMHLP YHVKRGATHV DVYRVDVVDV
310 320 330 340 350
LFEVVDIKDG LRSVSRKLTL QTVPVSVIEL IGLETADYCI RKENGMFTDW
360 370 380 390 400
FLLLTMLSDG LIDRRTHSQY LINPSSIPPD VIINIYVSGF TNRRVIDVMP
410 420 430 440 450
EMYDFVKPIG AVLPKGSFKS TIMRVLDEME VLGVRIMPRC HVVDSDEVGE
460 470 480 490 500
RMQPTFEHAV MEIYKGIAGV DSLEELINWV LGPDLIPHDE RLGKLYQSFL
510 520 530 540 550
PLAKDLLAPV ARHFYEESLS EGRLLTFAHA DSELLNANYF GHLLRLKIPF
560 570 580 590 600
ITEVNLMIRK NREGGELFQL VLSYLYKMYA TSAQPMWFGS LLRLMICPWL
610 620 630 640 650
HMEKLIGDAD AAITSAEVGW HIPKEHLMQD GWCGCEDGFI TYVVIRAPKL
660 670 680 690 700
VLEELREKNW GQYHAQVIVT DRLEVGEPRR VHARVVIKGN HMPSKLISRY
710 720 730
ACFSLTMRYM MHLTCGHSIG RSSAYGARLV FRSSLA
Length:736
Mass (Da):84,004
Last modified:December 1, 2001 - v1
Checksum:iC200281480E2FAA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF124519 Genomic RNA. Translation: AAK54467.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF124519 Genomic RNA. Translation: AAK54467.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR012494. Reovirus_Mu2.
[Graphical view ]
Pfami PF07781. Reovirus_Mu2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the reovirus Type 2 Jones M1 gene."
    Yin P., Keirstead N.D., Coombs K.M.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiMU2_REOVJ
AccessioniPrimary (citable) accession number: Q91PK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3