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Q91MX5

- PAP1_LSDV

UniProt

Q91MX5 - PAP1_LSDV

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Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Lumpy skin disease virus (LSDV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei193 – 1931By similarity
Active sitei195 – 1951By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
Gene namesi
Name:PAPL
Ordered Locus Names:LSDV032, LD032, LW032
OrganismiLumpy skin disease virus (LSDV)
Taxonomic identifieri59509 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeCapripoxvirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Poly(A) polymerase catalytic subunitPRO_0000308934Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ91MX5.
SMRiQ91MX5. Positions 5-472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91MX5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNDKIVVDVL KLYLKRDPSL TEFHMLKSQY KNIQRVNIFN KEIFISLIKK
60 70 80 90 100
NKKKFFSDIK SSPSDIKRSI LTYFSKQENT YSIGKLYTII ELQSILVTTY
110 120 130 140 150
TDVLGILTTK GPDLFTSNIY YNTSSMQSLA RDALNFMNVA QMTDKTMGRH
160 170 180 190 200
NVSSLVDNVN SLMEEYLRRH NKNCICYGSY SLHLLNPDVK YGDIDILQTN
210 220 230 240 250
SRTFLIDLAF LIKFITGLNV VLLKVPYLKN YMVLKDQNDS HIIDSFNIRQ
260 270 280 290 300
DTMQSIPKVL IDNIYIVDPA LQLMSMLKMF SQIDRLEDLA KNPEKLTVRL
310 320 330 340 350
ATLLEYVRVN YGINFISNQT KKNNMPMYSV IDIDKRIITV DTSNYDFPFK
360 370 380 390 400
KCLVYLDESS LSSDILDLNA DDAIDFENVS NSAFLINNNI LYTYFSNTIL
410 420 430 440 450
MKSKTDIHEI SSRGLSAHIL IYQILTKGDI IKPLTDIVNS LIGVEKNPIY
460 470
DIIPRDKKSG KHGIIDIEKD IITH
Length:474
Mass (Da):54,565
Last modified:December 1, 2001 - v1
Checksum:i3BD4209BEBDD14F7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231T → A in strain: isolate Neethling vaccine LW 1959.
Natural varianti270 – 2701A → T in strain: isolate Neethling vaccine LW 1959.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325528 Genomic DNA. Translation: AAK84993.1.
AF409137 Genomic DNA. Translation: AAN02600.1.
AF409138 Genomic DNA. Translation: AAN02757.1.
RefSeqiNP_150466.1. NC_003027.1.

Genome annotation databases

GeneIDi921671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325528 Genomic DNA. Translation: AAK84993.1 .
AF409137 Genomic DNA. Translation: AAN02600.1 .
AF409138 Genomic DNA. Translation: AAN02757.1 .
RefSeqi NP_150466.1. NC_003027.1.

3D structure databases

ProteinModelPortali Q91MX5.
SMRi Q91MX5. Positions 5-472.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 921671.

Family and domain databases

InterProi IPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view ]
Pfami PF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate Neethling 2490.
  2. "Comparative sequence analysis of the South African vaccine strain and two virulent field isolates of Lumpy skin disease virus."
    Kara P.D., Afonso C.L., Wallace D.B., Kutish G.F., Abolnik C., Lu Z., Vreede F.T., Taljaard L.C.F., Zsak A., Viljoen G.J., Rock D.L.
    Arch. Virol. 148:1335-1356(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate Neethling vaccine LW 1959 and Isolate Neethling Warmbaths LW.

Entry informationi

Entry nameiPAP1_LSDV
AccessioniPrimary (citable) accession number: Q91MX5
Secondary accession number(s): Q77GP9, Q8JTW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3