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Q91MX5

- PAP1_LSDV

UniProt

Q91MX5 - PAP1_LSDV

Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Lumpy skin disease virus (LSDV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Polymerase that creates the 3'-poly(A) tail of mRNA's.

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei193 – 1931By similarity
    Active sitei195 – 1951By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
    Alternative name(s):
    Poly(A) polymerase large subunit
    Short name:
    PAP-L
    Gene namesi
    Name:PAPL
    Ordered Locus Names:LSDV032, LD032, LW032
    OrganismiLumpy skin disease virus (LSDV)
    Taxonomic identifieri59509 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeCapripoxvirus
    Virus hostiBos taurus (Bovine) [TaxID: 9913]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474Poly(A) polymerase catalytic subunitPRO_0000308934Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ91MX5.
    SMRiQ91MX5. Positions 5-472.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view]
    PfamiPF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q91MX5-1 [UniParc]FASTAAdd to Basket

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    MNDKIVVDVL KLYLKRDPSL TEFHMLKSQY KNIQRVNIFN KEIFISLIKK    50
    NKKKFFSDIK SSPSDIKRSI LTYFSKQENT YSIGKLYTII ELQSILVTTY 100
    TDVLGILTTK GPDLFTSNIY YNTSSMQSLA RDALNFMNVA QMTDKTMGRH 150
    NVSSLVDNVN SLMEEYLRRH NKNCICYGSY SLHLLNPDVK YGDIDILQTN 200
    SRTFLIDLAF LIKFITGLNV VLLKVPYLKN YMVLKDQNDS HIIDSFNIRQ 250
    DTMQSIPKVL IDNIYIVDPA LQLMSMLKMF SQIDRLEDLA KNPEKLTVRL 300
    ATLLEYVRVN YGINFISNQT KKNNMPMYSV IDIDKRIITV DTSNYDFPFK 350
    KCLVYLDESS LSSDILDLNA DDAIDFENVS NSAFLINNNI LYTYFSNTIL 400
    MKSKTDIHEI SSRGLSAHIL IYQILTKGDI IKPLTDIVNS LIGVEKNPIY 450
    DIIPRDKKSG KHGIIDIEKD IITH 474
    Length:474
    Mass (Da):54,565
    Last modified:December 1, 2001 - v1
    Checksum:i3BD4209BEBDD14F7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti123 – 1231T → A in strain: isolate Neethling vaccine LW 1959.
    Natural varianti270 – 2701A → T in strain: isolate Neethling vaccine LW 1959.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325528 Genomic DNA. Translation: AAK84993.1.
    AF409137 Genomic DNA. Translation: AAN02600.1.
    AF409138 Genomic DNA. Translation: AAN02757.1.
    RefSeqiNP_150466.1. NC_003027.1.

    Genome annotation databases

    GeneIDi921671.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325528 Genomic DNA. Translation: AAK84993.1 .
    AF409137 Genomic DNA. Translation: AAN02600.1 .
    AF409138 Genomic DNA. Translation: AAN02757.1 .
    RefSeqi NP_150466.1. NC_003027.1.

    3D structure databases

    ProteinModelPortali Q91MX5.
    SMRi Q91MX5. Positions 5-472.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 921671.

    Family and domain databases

    InterProi IPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view ]
    Pfami PF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate Neethling 2490.
    2. "Comparative sequence analysis of the South African vaccine strain and two virulent field isolates of Lumpy skin disease virus."
      Kara P.D., Afonso C.L., Wallace D.B., Kutish G.F., Abolnik C., Lu Z., Vreede F.T., Taljaard L.C.F., Zsak A., Viljoen G.J., Rock D.L.
      Arch. Virol. 148:1335-1356(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate Neethling vaccine LW 1959 and Isolate Neethling Warmbaths LW.

    Entry informationi

    Entry nameiPAP1_LSDV
    AccessioniPrimary (citable) accession number: Q91MX5
    Secondary accession number(s): Q77GP9, Q8JTW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3