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Q91MX5

- PAP1_LSDV

UniProt

Q91MX5 - PAP1_LSDV

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Protein
Poly(A) polymerase catalytic subunit
Gene
PAPL, LSDV032, LD032, LW032
Organism
Lumpy skin disease virus (LSDV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei193 – 1931 By similarity
Active sitei195 – 1951 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
Gene namesi
Name:PAPL
Ordered Locus Names:LSDV032, LD032, LW032
OrganismiLumpy skin disease virus (LSDV)
Taxonomic identifieri59509 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeCapripoxvirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Poly(A) polymerase catalytic subunit
PRO_0000308934Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ91MX5.
SMRiQ91MX5. Positions 5-472.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91MX5-1 [UniParc]FASTAAdd to Basket

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MNDKIVVDVL KLYLKRDPSL TEFHMLKSQY KNIQRVNIFN KEIFISLIKK    50
NKKKFFSDIK SSPSDIKRSI LTYFSKQENT YSIGKLYTII ELQSILVTTY 100
TDVLGILTTK GPDLFTSNIY YNTSSMQSLA RDALNFMNVA QMTDKTMGRH 150
NVSSLVDNVN SLMEEYLRRH NKNCICYGSY SLHLLNPDVK YGDIDILQTN 200
SRTFLIDLAF LIKFITGLNV VLLKVPYLKN YMVLKDQNDS HIIDSFNIRQ 250
DTMQSIPKVL IDNIYIVDPA LQLMSMLKMF SQIDRLEDLA KNPEKLTVRL 300
ATLLEYVRVN YGINFISNQT KKNNMPMYSV IDIDKRIITV DTSNYDFPFK 350
KCLVYLDESS LSSDILDLNA DDAIDFENVS NSAFLINNNI LYTYFSNTIL 400
MKSKTDIHEI SSRGLSAHIL IYQILTKGDI IKPLTDIVNS LIGVEKNPIY 450
DIIPRDKKSG KHGIIDIEKD IITH 474
Length:474
Mass (Da):54,565
Last modified:December 1, 2001 - v1
Checksum:i3BD4209BEBDD14F7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231T → A in strain: isolate Neethling vaccine LW 1959.
Natural varianti270 – 2701A → T in strain: isolate Neethling vaccine LW 1959.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325528 Genomic DNA. Translation: AAK84993.1.
AF409137 Genomic DNA. Translation: AAN02600.1.
AF409138 Genomic DNA. Translation: AAN02757.1.
RefSeqiNP_150466.1. NC_003027.1.

Genome annotation databases

GeneIDi921671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325528 Genomic DNA. Translation: AAK84993.1 .
AF409137 Genomic DNA. Translation: AAN02600.1 .
AF409138 Genomic DNA. Translation: AAN02757.1 .
RefSeqi NP_150466.1. NC_003027.1.

3D structure databases

ProteinModelPortali Q91MX5.
SMRi Q91MX5. Positions 5-472.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 921671.

Family and domain databases

InterProi IPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view ]
Pfami PF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate Neethling 2490.
  2. "Comparative sequence analysis of the South African vaccine strain and two virulent field isolates of Lumpy skin disease virus."
    Kara P.D., Afonso C.L., Wallace D.B., Kutish G.F., Abolnik C., Lu Z., Vreede F.T., Taljaard L.C.F., Zsak A., Viljoen G.J., Rock D.L.
    Arch. Virol. 148:1335-1356(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate Neethling vaccine LW 1959 and Isolate Neethling Warmbaths LW.

Entry informationi

Entry nameiPAP1_LSDV
AccessioniPrimary (citable) accession number: Q91MX5
Secondary accession number(s): Q77GP9, Q8JTW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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