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Q91MX5 (PAP1_LSDV) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly(A) polymerase catalytic subunit

EC=2.7.7.19
Alternative name(s):
Poly(A) polymerase large subunit
Short name=PAP-L
Gene names
Name:PAPL
Ordered Locus Names:LSDV032, LD032, LW032
OrganismLumpy skin disease virus (LSDV)
Taxonomic identifier59509 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeCapripoxvirus
Virus hostBos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activity

ATP + RNA(n) = diphosphate + RNA(n+1).

Subunit structure

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit By similarity.

Sequence similarities

Belongs to the poxviridae poly(A) polymerase catalytic subunit family.

Ontologies

Keywords
   Biological processmRNA processing
Transcription
   LigandATP-binding
Nucleotide-binding
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processmRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

polynucleotide adenylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Poly(A) polymerase catalytic subunit
PRO_0000308934

Sites

Active site1931 By similarity
Active site1951 By similarity

Natural variations

Natural variant1231T → A in strain: isolate Neethling vaccine LW 1959.
Natural variant2701A → T in strain: isolate Neethling vaccine LW 1959.

Sequences

Sequence LengthMass (Da)Tools
Q91MX5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 3BD4209BEBDD14F7

FASTA47454,565
        10         20         30         40         50         60 
MNDKIVVDVL KLYLKRDPSL TEFHMLKSQY KNIQRVNIFN KEIFISLIKK NKKKFFSDIK 

        70         80         90        100        110        120 
SSPSDIKRSI LTYFSKQENT YSIGKLYTII ELQSILVTTY TDVLGILTTK GPDLFTSNIY 

       130        140        150        160        170        180 
YNTSSMQSLA RDALNFMNVA QMTDKTMGRH NVSSLVDNVN SLMEEYLRRH NKNCICYGSY 

       190        200        210        220        230        240 
SLHLLNPDVK YGDIDILQTN SRTFLIDLAF LIKFITGLNV VLLKVPYLKN YMVLKDQNDS 

       250        260        270        280        290        300 
HIIDSFNIRQ DTMQSIPKVL IDNIYIVDPA LQLMSMLKMF SQIDRLEDLA KNPEKLTVRL 

       310        320        330        340        350        360 
ATLLEYVRVN YGINFISNQT KKNNMPMYSV IDIDKRIITV DTSNYDFPFK KCLVYLDESS 

       370        380        390        400        410        420 
LSSDILDLNA DDAIDFENVS NSAFLINNNI LYTYFSNTIL MKSKTDIHEI SSRGLSAHIL 

       430        440        450        460        470 
IYQILTKGDI IKPLTDIVNS LIGVEKNPIY DIIPRDKKSG KHGIIDIEKD IITH 

« Hide

References

[1]"Genome of lumpy skin disease virus."
Tulman E.R., Afonso C.L., Lu Z., Zsak L., Kutish G.F., Rock D.L.
J. Virol. 75:7122-7130(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Isolate Neethling 2490.
[2]"Comparative sequence analysis of the South African vaccine strain and two virulent field isolates of Lumpy skin disease virus."
Kara P.D., Afonso C.L., Wallace D.B., Kutish G.F., Abolnik C., Lu Z., Vreede F.T., Taljaard L.C.F., Zsak A., Viljoen G.J., Rock D.L.
Arch. Virol. 148:1335-1356(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Isolate Neethling vaccine LW 1959 and Isolate Neethling Warmbaths LW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF325528 Genomic DNA. Translation: AAK84993.1.
AF409137 Genomic DNA. Translation: AAN02600.1.
AF409138 Genomic DNA. Translation: AAN02757.1.
RefSeqNP_150466.1. NC_003027.1.

3D structure databases

ProteinModelPortalQ91MX5.
SMRQ91MX5. Positions 5-472.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID921671.

Family and domain databases

InterProIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFPIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNetSearch...

Entry information

Entry namePAP1_LSDV
AccessionPrimary (citable) accession number: Q91MX5
Secondary accession number(s): Q77GP9, Q8JTW7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families