Q91LS8 (Q91LS8_9INFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hemagglutinin EMBL AAK82869.1

Gene names

Name:

HA EMBL AAK82869.1

Organism

Influenza A virus (A/Taiwan/0095/1996(H3N2)) EMBL AAK82869.1

Taxonomic identifier

162497 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A › Influenza A virus › H3N2 subtype

Protein attributes

Sequence length	281 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore By similarity. RuleBase RU003324
Subunit structure	Homotrimer of disulfide-linked HA1-HA2 By similarity. RuleBase RU003324 SAAS SAAS008980
Sequence similarities	Belongs to the influenza viruses hemagglutinin family. RuleBase RU003324

Ontologies

Keywords
Biological process	Clathrin- and caveolin-independent endocytosis of virus by host SAAS SAAS008980 Clathrin-mediated endocytosis of virus by host SAAS SAAS008980 Fusion of virus membrane with host endosomal membrane SAAS SAAS008980 Fusion of virus membrane with host membrane Host-virus interaction Viral attachment to host cell SAAS SAAS008980 Viral penetration into host cytoplasm Virus endocytosis by host Virus entry into host cell
Cellular component	Host cell membrane SAAS SAAS008980 Host membrane Membrane Viral envelope protein RuleBase RU003324 SAAS SAAS008980 Virion
Molecular function	Hemagglutinin RuleBase RU003324 SAAS SAAS008980
PTM	Disulfide bond SAAS SAAS000149
Technical term	3D-structure PDB 2OJE
Gene Ontology (GO)
Biological_process	viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell via clathrin-mediated endocytosis Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell via membrane fusion with the plasma membrane Inferred from electronic annotation. Source: InterPro
Cellular_component	host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAK82869.1
	Non-terminal residue	281	1	EMBL AAK82869.1

Sequences

	Sequence		Length	Mass (Da)
	Q91LS8 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 63B306D7AD351E2D	FASTA	281	31,362
	10 20 30 40 50 60 STGRICDSPH RILDGKNCTL IDALLGDPHC DGFQNKEWDL FVERSKAYSN CYPYDVPDYA 70 80 90 100 110 120 SLRSLVASSG TLEFTNEGFN WTGVAQNGTS YACKRGSVKS FFSRLNWLHK LEYKYPALNV 130 140 150 160 170 180 TMPNNDKFDK LYIWGVHHPS TDSDQTSLYV QASGRITVST KRSQQTVIPN IGSRPWVRGV 190 200 210 220 230 240 SSIISIYWTI VKPGDILLIN STGNLIAPRG YFKIRSGKSS IMRSDAPIGN CNSECITPNG 250 260 270 280 SIPNDKPFQN VNRITYGACP KYVKQNTLKL ATGMRNVPEK Q

References

[1]	"Browser-Based Java Applications for Search and Analysis of Influenza Sequences in GenBank Format." Shih S.-R., Chen G.-W., Bair C.-H., Bai Y.-L., Yang C.-C., Tsai M.-C. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: A/human/Taiwan/0095/96 EMBL AAK82869.1.
[2]	"Zinc induces dimerization of the class II major histocompatibility complex molecule that leads to cooperative binding to a superantigen." Li H., Zhao Y., Guo Y., Li Z., Eisele L., Mourad W. J. Biol. Chem. 282:5991-6000(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 260-272.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF362820 mRNA. Translation: AAK82869.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2OJE	X-ray	3.00	C/G	260-272	[»]

ProteinModelPortal

Q91LS8.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

2.10.77.10. 1 hit.
3.90.209.20. 1 hit.

InterPro

IPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
[Graphical view]

Pfam

PF00509. Hemagglutinin. 1 hit.
[Graphical view]

PRINTS

PR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.

SUPFAM

SSF49818. Capsid_hemag. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q91LS8.

Entry information

Entry name

Q91LS8_9INFA

Accession

Primary (citable) accession number: Q91LS8

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	March 6, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)