Reviewed, UniProtKB/Swiss-Prot Q91GE3 (CATV_NPVEP)

Names and origin

Protein names

Recommended name:
    Viral cathepsin
      Short name=V-cath
    EC=3.4.22.50
Alternative name(s):
    Cysteine proteinase
      Short name=CP

Gene names

Name:	VCATH
Synonyms:	111

Organism

Epiphyas postvittana nucleopolyhedrovirus (EppoMNPV)

Taxonomic identifier

70600 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Baculoviridae › Alphabaculovirus

Virus host

Lepidoptera (butterflies and moths) [TaxID: 7088]

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system By similarity.
Catalytic activity	Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.
Post-translational modification	Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide By similarity.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 112	94	Activation peptide Potential		PRO_0000322209
	Chain	113 – 323	211	Viral cathepsin		PRO_0000050579
Sites
	Active site	136	1	By similarity
	Active site	269	1	By similarity
	Active site	289	1	By similarity
Amino acid modifications
	Glycosylation	158	1	N-linked (GlcNAc...); by host Potential
	Disulfide bond	133 ↔ 174		By similarity
	Disulfide bond	167 ↔ 207		By similarity
	Disulfide bond	262 ↔ 310		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91GE3-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: A0EB527CC5FF740E	FASTA	323	36,835
	10 20 30 40 50 60 MSKFLLYWFV YGVVCSAAYD ILKAPNYFEE FVRQYNKQYD SEYEKLRRYK IFQHNLNDII 70 80 90 100 110 120 TKNRNDTAVY KINKFSDLSK DETIAKYTGL SLPLHTQNFC EVVVLDRPPG KGPLEFDWRR 130 140 150 160 170 180 FNKITSVKNQ GMCGACWAFA TLASLESQFA IAHDRLINLS EQQMIDCDSV DVGCEGGLLH 190 200 210 220 230 240 TAFEAIISMG GVQIENDYPY ESSNNYCRMD PTKFVVGVKQ CNRYITIYEE KLKDVLRLAG 250 260 270 280 290 300 PIPVAIDASD ILNYEQGIIK YCANNGLNHA VLLVGYGVEN NVPYWILKNS WGTDWGEQGF 310 320 FKIQQNVNAC GIKNELASTA EIN

References

[1]

"Whole genome analysis of the Epiphyas postvittana nucleopolyhedrovirus." Hyink O., Dellow R.A., Olsen M.J., Caradoc-Davies K.M.B., Drake K., Herniou E.A., Cory J.S., O'Reilly D.R., Ward V.K. J. Gen. Virol. 83:957-971(2002) [PubMed: 11907346] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY043265 Genomic DNA. Translation: AAK85675.1.
RefSeq	NP_203280.1.
3D structure databases
HSSP	HSSP built from PDB template 1K3B based on UniProtKB P53634.
ModBase	Search...
Protein family/group databases
MEROPS	C01.083.
Genome annotation databases
GeneID	921832.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHER	PTHR12411. Peptidase_C1A. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
ProDom	PD000158. Peptidase_C1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATV_NPVEP

Accession

Primary (citable) accession number: Q91GE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	December 1, 2001
Last modified:	May 5, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)