Q91FW5 (VF205_IIV6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative DNA ligase 205R
EC=6.5.1.2

Gene names

ORF Names:

IIV6-205R

Organism

Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) [Reference proteome]

Taxonomic identifier

176652 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Iridovirus

Virus host

Acheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]

Protein attributes

Sequence length	615 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction By similarity.
Catalytic activity	NAD+ + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)(n+m).
Sequence similarities	Belongs to the NAD-dependent DNA ligase family.

Ontologies

Keywords
Biological process	DNA replication
Ligand	NAD
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: InterPro DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro DNA ligase (NAD+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 615	615	Putative DNA ligase 205R		PRO_0000376962
Sites
	Active site	101	1	N6-AMP-lysine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91FW5 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: A3B98D1C37B317A8	FASTA	615	70,152
	10 20 30 40 50 60 MDETQQLLYK FKNLTISENE KLKLKEKADH FYFNTEKEIL TDNEYDILAE QLQSTNVGCS 70 80 90 100 110 120 PLISKTDLPL WMGSLDKVYN DKELNLWIKK VASDKYIIQC KLDGVSCLII NKDNKLKAYT 130 140 150 160 170 180 RGNGKVGTDI SHLIKYFIKD KCLPNNIALR CEIIIKKETF NQKYKHAFSN PRSFVSGVVN 190 200 210 220 230 240 RKQENIVISE LNDLCLIAYE LINFPVNEYQ KNILTQIEII EQLNFIQFVN FKTISNEFLT 250 260 270 280 290 300 QKALSNLFKE MKNNSLFEMD GLVILANTPY IRVTEGNPKH SIAFKVRGDN VKEAKVTFIE 310 320 330 340 350 360 WNVGKTGVFT PKVHIVPTEI NGTTVSCFTG FNANYLIEKG IGEGAIILVT RAGDAIPQII 370 380 390 400 410 420 GVKQTGVLTF PKDYEWKGDC RIVEKIESKE RIIKQILHFV ESVDIPYIKE ATINKLYNNG 430 440 450 460 470 480 CTSIELFLKL TQKDLLLFGP KLSSTIYNSI QKSFEAPIEK FLSGYNAFGD YIGEKKILLL 490 500 510 520 530 540 LQKYPNLFEL ENLDAIDLVS IEGIGSKTAT QIKQHFINAK LIYNNIIQNK LFKGVLHTPS 550 560 570 580 590 600 KQNTVELFKV CVSGTRDPLF IQELKNRGFV LSDNITKKVK VLIVKNSNEE TTKVKKANSV 610 GITILTLEDF KQKYF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus." Jakob N.J., Mueller K., Bahr U., Darai G. Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes." Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R. Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF303741 Genomic DNA. Translation: AAK82067.1.
RefSeq	NP_149668.1. NC_003038.1.
3D structure databases
ProteinModelPortal	Q91FW5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1733308.
Phylogenomic databases
ProtClustDB	CLSP2511666.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
InterPro	IPR004150. DNA_ligase_OB. IPR001679. DNAligase. IPR013839. DNAligase_adenylation. IPR013840. DNAligase_N. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR012340. NA-bd_OB-fold. IPR010994. RuvA_2-like. [Graphical view]
PANTHER	PTHR11107:SF5. PTHR11107:SF5. 1 hit.
Pfam	PF01653. DNA_ligase_aden. 1 hit. PF03120. DNA_ligase_OB. 1 hit. [Graphical view]
PIRSF	PIRSF001604. LigA. 1 hit.
SMART	SM00278. HhH1. 1 hit. SM00532. LIGANc. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF47781. RuvA_2_like. 1 hit.
PROSITE	PS01055. DNA_LIGASE_N1. False negative. PS01056. DNA_LIGASE_N2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VF205_IIV6

Accession

Primary (citable) accession number: Q91FW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program