Q91FU0 (VF232_IIV6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative ubiquitin thioesterase 232R
EC=3.4.19.12

Gene names

ORF Names:

IIV6-232R

Organism

Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) [Reference proteome]

Taxonomic identifier

176652 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Iridovirus

Virus host

Acheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]

Protein attributes

Sequence length	671 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation By similarity.
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Sequence similarities	Contains 1 OTU domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA-dependent transcription, termination Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 671	671	Putative ubiquitin thioesterase 232R		PRO_0000377774
Regions
	Domain	392 – 521	130	OTU
	Compositional bias	255 – 352	98	Arg/Ser-rich
	Compositional bias	548 – 581	34	Glu-rich
Sites
	Active site	400	1	Potential
	Active site	403	1	Nucleophile By similarity
	Active site	514	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q91FU0 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 1FD36D7AC7D67CCA	FASTA	671	75,605
	10 20 30 40 50 60 MNNNQCMRKK LDELRNIARS YNISITGKKK QQLCDEIIDY QKNNPPRRSP SPRRSPSPRR 70 80 90 100 110 120 ISPECEQWLA NKGINPRTGK AIKIGGPTYK KLEMECKEAS PKIPSPVRQP SPVHSPVRSP 130 140 150 160 170 180 VRQPSPVRFV EKTKGALNKM KKDQLIDFAQ SLGLNPGKLL KPALVDLIFV NQKPPRRSPS 190 200 210 220 230 240 PRRSPSPRRS PSPRRSPSPR PVFVEKTKGA LNKMKKDQLI DLAQSLGLNP GKLLKPALVD 250 260 270 280 290 300 LIFVNQKPVE PIRASSSSRS SRSTRRSSST KPSRRSSSRS RRSSSRSRRS SSRSRRSSSR 310 320 330 340 350 360 SRRSSRRSTS RSRSLSKRSI RNISTVGDLE DLVASNLPIA IPESLSRSLS PSRTDFHEAE 370 380 390 400 410 420 IELGSDFDLN NLPENRIAEL KQLNVLAKQN GFRMINVPLD GNCMFSVIGR AFNTSSSVIR 430 440 450 460 470 480 QHTVDYLRRC KGSFDHIPAN IDDPTINWND YIDRLEEDAC WGDNTALFAA SLALNFQAHI 490 500 510 520 530 540 LQVAGGDEGS WIRFGVNETN MGRIVNMGYL DNFHYIALEP FSGRLDILSI PSTHSKCPPP 550 560 570 580 590 600 EISNRRDEEI RRDEEVEDEV IGERIVREAE VIERELRQEE ELTSIVSTKR SLRPSIPPKI 610 620 630 640 650 660 STEHRRTPKL RPSVPRPSSI RQSQPNVAAL ARLETLTKIK DIIDALQRPL ENKLSTLTNT 670 EKAIMQCIGV A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus." Jakob N.J., Mueller K., Bahr U., Darai G. Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes." Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R. Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF303741 Genomic DNA. Translation: AAK82093.1.
RefSeq	NP_149695.1. NC_003038.1.
3D structure databases
ProteinModelPortal	Q91FU0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1733388.
Phylogenomic databases
ProtClustDB	CLSP2511671.
Family and domain databases
InterPro	IPR014901. 2-cysteine_adaptor. IPR003323. OTU. IPR011112. Rho_N. [Graphical view]
Pfam	PF08793. 2C_adapt. 1 hit. PF02338. OTU. 1 hit. PF07498. Rho_N. 1 hit. [Graphical view]
SMART	SM00959. Rho_N. 3 hits. [Graphical view]
PROSITE	PS50802. OTU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VF232_IIV6

Accession

Primary (citable) accession number: Q91FU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program