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Q91FU0

- VF232_IIV6

UniProt

Q91FU0 - VF232_IIV6

Protein

Putative ubiquitin thioesterase 232R

Gene

IIV6-232R

Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei400 – 4001Sequence Analysis
    Active sitei403 – 4031NucleophileBy similarity
    Active sitei514 – 5141Sequence Analysis

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. DNA-templated transcription, termination Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ubiquitin thioesterase 232R (EC:3.4.19.12)
    Gene namesi
    ORF Names:IIV6-232R
    OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
    Taxonomic identifieri176652 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
    Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
    Chilo suppressalis (striped riceborer) [TaxID: 168631]
    Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
    Gryllus campestris [TaxID: 58607]
    Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
    ProteomesiUP000001359: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 671671Putative ubiquitin thioesterase 232RPRO_0000377774Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ91FU0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini392 – 521130OTUPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi255 – 35298Arg/Ser-richAdd
    BLAST
    Compositional biasi548 – 58134Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR014901. 2-cysteine_adaptor.
    IPR003323. OTU.
    IPR011112. Rho_N.
    [Graphical view]
    PfamiPF08793. 2C_adapt. 1 hit.
    PF02338. OTU. 1 hit.
    PF07498. Rho_N. 1 hit.
    [Graphical view]
    SMARTiSM00959. Rho_N. 3 hits.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91FU0-1 [UniParc]FASTAAdd to Basket

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    MNNNQCMRKK LDELRNIARS YNISITGKKK QQLCDEIIDY QKNNPPRRSP    50
    SPRRSPSPRR ISPECEQWLA NKGINPRTGK AIKIGGPTYK KLEMECKEAS 100
    PKIPSPVRQP SPVHSPVRSP VRQPSPVRFV EKTKGALNKM KKDQLIDFAQ 150
    SLGLNPGKLL KPALVDLIFV NQKPPRRSPS PRRSPSPRRS PSPRRSPSPR 200
    PVFVEKTKGA LNKMKKDQLI DLAQSLGLNP GKLLKPALVD LIFVNQKPVE 250
    PIRASSSSRS SRSTRRSSST KPSRRSSSRS RRSSSRSRRS SSRSRRSSSR 300
    SRRSSRRSTS RSRSLSKRSI RNISTVGDLE DLVASNLPIA IPESLSRSLS 350
    PSRTDFHEAE IELGSDFDLN NLPENRIAEL KQLNVLAKQN GFRMINVPLD 400
    GNCMFSVIGR AFNTSSSVIR QHTVDYLRRC KGSFDHIPAN IDDPTINWND 450
    YIDRLEEDAC WGDNTALFAA SLALNFQAHI LQVAGGDEGS WIRFGVNETN 500
    MGRIVNMGYL DNFHYIALEP FSGRLDILSI PSTHSKCPPP EISNRRDEEI 550
    RRDEEVEDEV IGERIVREAE VIERELRQEE ELTSIVSTKR SLRPSIPPKI 600
    STEHRRTPKL RPSVPRPSSI RQSQPNVAAL ARLETLTKIK DIIDALQRPL 650
    ENKLSTLTNT EKAIMQCIGV A 671
    Length:671
    Mass (Da):75,605
    Last modified:December 1, 2001 - v1
    Checksum:i1FD36D7AC7D67CCA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303741 Genomic DNA. Translation: AAK82093.1.
    RefSeqiNP_149695.1. NC_003038.1.

    Genome annotation databases

    GeneIDi1733388.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303741 Genomic DNA. Translation: AAK82093.1 .
    RefSeqi NP_149695.1. NC_003038.1.

    3D structure databases

    ProteinModelPortali Q91FU0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1733388.

    Family and domain databases

    InterProi IPR014901. 2-cysteine_adaptor.
    IPR003323. OTU.
    IPR011112. Rho_N.
    [Graphical view ]
    Pfami PF08793. 2C_adapt. 1 hit.
    PF02338. OTU. 1 hit.
    PF07498. Rho_N. 1 hit.
    [Graphical view ]
    SMARTi SM00959. Rho_N. 3 hits.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
      Jakob N.J., Mueller K., Bahr U., Darai G.
      Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
      Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
      Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.

    Entry informationi

    Entry nameiVF232_IIV6
    AccessioniPrimary (citable) accession number: Q91FU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3