Q91FS1 (KTHY_IIV6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidylate kinase 251L
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

ORF Names:

IIV6-251L

Organism

Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) [Reference proteome]

Taxonomic identifier

176652 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Iridovirus

Virus host

Acheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of dTMP to dTDP By similarity.
Catalytic activity	ATP + dTMP = ADP + dTDP.
Pathway	Pyrimidine metabolism; dTTP biosynthesis.
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Putative thymidylate kinase 251L		PRO_0000376900
Regions
	Nucleotide binding	21 – 28	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q91FS1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 11D30006BDEFD5ED	FASTA	213	24,815
	10 20 30 40 50 60 MSLKQSFPLL ETRGLLIVFE GCDKTGKSTQ CKLLFEELKQ KNIEVRMINF PNRTTQTGKL 70 80 90 100 110 120 IDQYLKGKIY LSDEDIHILF SKNRWEIIDT IKTNILNGIT VIIDRYSYSG IAFSVAKGLD 130 140 150 160 170 180 FQWCKQTENG LLKPDIIIYL TGQTKNMASR NGYGSEIYER IEIQDKVKKC YEKMIEIPLW 190 200 210 NKINADQDVL IIKKQIETII QKFSLENNKL EYI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus." Jakob N.J., Mueller K., Bahr U., Darai G. Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes." Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R. Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF303741 Genomic DNA. Translation: AAK82112.1.
RefSeq	NP_149714.1. NC_003038.1.
3D structure databases
HSSP	HSSP built from PDB template 1TMK based on UniProtKB P00572.
ProteinModelPortal	Q91FS1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1733213.
Phylogenomic databases
ProtClustDB	CLSP2509845.
Enzyme and pathway databases
UniPathway	UPA00575.
Family and domain databases
InterPro	IPR018095. Thymidylate_kin_CS. IPR018094. Thymidylate_kinase. [Graphical view]
PANTHER	PTHR10344. PTHR10344. 1 hit.
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_IIV6

Accession

Primary (citable) accession number: Q91FS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program