Q91FF5 (VF369_IIV6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable RAD2-like endonuclease 369L
EC=3.1.-.-

Gene names

ORF Names:

IIV6-369L

Organism

Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) [Reference proteome]

Taxonomic identifier

176652 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Iridovirus

Virus host

Acheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probable endonuclease Potential.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Subcellular location	Host nucleus By similarity.
Sequence similarities	Belongs to the XPG/RAD2 endonuclease family.

Ontologies

Keywords
Cellular component	Host nucleus
Ligand	Magnesium Metal-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: InterPro nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 415	415	Probable RAD2-like endonuclease 369L		PRO_0000377501
Regions
	Region	1 – 114	114	N-domain By similarity
	Region	163 – 297	135	I-domain By similarity
Sites
	Metal binding	34	1	Magnesium 1 By similarity
	Metal binding	86	1	Magnesium 1 By similarity
	Metal binding	198	1	Magnesium 1 By similarity
	Metal binding	200	1	Magnesium 1 By similarity
	Metal binding	219	1	Magnesium 2 By similarity
	Metal binding	221	1	Magnesium 2 By similarity
	Metal binding	277	1	Magnesium 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91FF5 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: CE6E457A686F11F3	FASTA	415	49,317
	10 20 30 40 50 60 MGIKNLTKFI KEKCQEAYVT ENINELSFKK IAIDTPMYMY KYKSMNAAKM VENNGIYYNP 70 80 90 100 110 120 DGWLWSFIYF IYSLRKHDIH PIFILEGGYP EEKNKTRMAR KKDREDVKKK TLSLEESISS 130 140 150 160 170 180 YATSLRLRPE DIPQDLKEEW NKIAKKNNLP FEDFDFETVK DHVKQRHRYD IRITNRDYEK 190 200 210 220 230 240 LKILLKIMNT PFIQAPMEAE AFCAYLYKKK IIHGIASNDS DILAYGCNLI VDFEFDVKID 250 260 270 280 290 300 EETKISKITY INYDYLLNKL DLQSSEFLDF CIMCGTDYND NIYRIGAVKS YELIKVQKCI 310 320 330 340 350 360 ENVGKFLDPN NKKGTILILN HLRIRHIFNH YGMKNIDDVT NMQFLEKKAS WSSVPNFYLL 370 380 390 400 410 TMLTIKFNIN IDLEWIRHGF EKCNIKWDCE SEYEENVEKT NVEETNNEVD EFPIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus." Jakob N.J., Mueller K., Bahr U., Darai G. Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes." Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R. Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF303741 Genomic DNA. Translation: AAK82229.1.
RefSeq	NP_149832.1. NC_003038.1.
3D structure databases
HSSP	HSSP built from PDB template 1UL1 based on UniProtKB P39748.
ProteinModelPortal	Q91FF5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1733029.
Phylogenomic databases
ProtClustDB	CLSP2511689.
Family and domain databases
InterPro	IPR020045. 5-3_exonuclease_C. IPR006086. XPG-I_dom. IPR006084. XPG/Rad2. IPR006085. XPG_DNA_repair_N. [Graphical view]
PANTHER	PTHR11081. PTHR11081. 1 hit.
Pfam	PF00867. XPG_I. 1 hit. PF00752. XPG_N. 1 hit. [Graphical view]
PRINTS	PR00853. XPGRADSUPER.
SMART	SM00484. XPGI. 1 hit. SM00485. XPGN. 1 hit. [Graphical view]
SUPFAM	SSF47807. 5_3_exo_C. 1 hit.
PROSITE	PS00841. XPG_1. False negative. PS00842. XPG_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VF369_IIV6

Accession

Primary (citable) accession number: Q91FF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program