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Protein

Probable ribonucleoside-diphosphate reductase small subunit 376L

Gene

IIV6-376L

Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Iron 1By similarity1
Metal bindingi98Iron 1By similarity1
Metal bindingi98Iron 2By similarity1
Metal bindingi101Iron 1By similarity1
Active sitei105By similarity1
Metal bindingi172Iron 2By similarity1
Metal bindingi206Iron 2By similarity1
Metal bindingi209Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDNA replication
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribonucleoside-diphosphate reductase small subunit 376L (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
ORF Names:IIV6-376L
OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Taxonomic identifieri176652 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeBetairidovirinaeIridovirus
Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (Asiatic rice borer moth) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
Proteomesi
  • UP000001359 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003769101 – 360Probable ribonucleoside-diphosphate reductase small subunit 376LAdd BLAST360

Proteomic databases

PRIDEiQ91FE8

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ91FE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00526
OrthoDBiVOG090000AL

Family and domain databases

CDDicd01049 RNRR2, 1 hit
Gene3Di1.10.620.20, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR012348 RNR-like
IPR033909 RNR_small
IPR000358 RNR_small_fam
PANTHERiPTHR23409 PTHR23409, 1 hit
PfamiView protein in Pfam
PF00268 Ribonuc_red_sm, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit

Sequencei

Sequence statusi: Complete.

Q91FE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLKGRNYY KPFTYPEFYN KWDKHEKSHW LPSEVPMHDD VNDWKNRLND
60 70 80 90 100
NQRDFLTNIF RFFTQGDVDV ASAYYTQYLP FFKLPEVTMM MGGFAGREGV
110 120 130 140 150
HIDAYSYLLE TLGMPEATYK EFLMYEEMKD KQDYIKKFSD SRHILGKGEE
160 170 180 190 200
NLTTEDKEHI AAGIALFSGF TEGMQLFSTF AMLLIFPLNG FMKGMGQIVT
210 220 230 240 250
WSIVDETQHT EGMIELFKVF VEENKTGDQP IRPSVLQETV YKIAKEMVGL
260 270 280 290 300
EEAFIDLVFK KYKDEPINDD NDLETKDNKD FFGLTPQRLK AYIKYIADRR
310 320 330 340 350
LNLMGYKSIF NLEPYPTNPL PELEIMINAP THTNFFENRS TDYANVSTKG
360
TWSEIWNKPQ
Length:360
Mass (Da):42,154
Last modified:December 1, 2001 - v1
Checksum:iD21CAE2D31961145
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303741 Genomic DNA Translation: AAK82236.1
RefSeqiNP_149839.1, NC_003038.1

Genome annotation databases

GeneIDi1733046
KEGGivg:1733046

Similar proteinsi

Entry informationi

Entry nameiRIR2_IIV6
AccessioniPrimary (citable) accession number: Q91FE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health