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Q91FE8 (RIR2_IIV6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ribonucleoside-diphosphate reductase small subunit 376L

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
ORF Names:IIV6-376L
OrganismInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) [Reference proteome]
Taxonomic identifier176652 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
Virus hostAcheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Probable ribonucleoside-diphosphate reductase small subunit 376L
PRO_0000376910

Sites

Active site1051 By similarity
Metal binding671Iron 1 By similarity
Metal binding981Iron 1 By similarity
Metal binding981Iron 2 By similarity
Metal binding1011Iron 1 By similarity
Metal binding1721Iron 2 By similarity
Metal binding2061Iron 2 By similarity
Metal binding2091Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91FE8 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: D21CAE2D31961145

FASTA36042,154
        10         20         30         40         50         60 
MSLLKGRNYY KPFTYPEFYN KWDKHEKSHW LPSEVPMHDD VNDWKNRLND NQRDFLTNIF 

        70         80         90        100        110        120 
RFFTQGDVDV ASAYYTQYLP FFKLPEVTMM MGGFAGREGV HIDAYSYLLE TLGMPEATYK 

       130        140        150        160        170        180 
EFLMYEEMKD KQDYIKKFSD SRHILGKGEE NLTTEDKEHI AAGIALFSGF TEGMQLFSTF 

       190        200        210        220        230        240 
AMLLIFPLNG FMKGMGQIVT WSIVDETQHT EGMIELFKVF VEENKTGDQP IRPSVLQETV 

       250        260        270        280        290        300 
YKIAKEMVGL EEAFIDLVFK KYKDEPINDD NDLETKDNKD FFGLTPQRLK AYIKYIADRR 

       310        320        330        340        350        360 
LNLMGYKSIF NLEPYPTNPL PELEIMINAP THTNFFENRS TDYANVSTKG TWSEIWNKPQ 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
Jakob N.J., Mueller K., Bahr U., Darai G.
Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF303741 Genomic DNA. Translation: AAK82236.1.
RefSeqNP_149839.1. NC_003038.1.

3D structure databases

ProteinModelPortalQ91FE8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1733046.

Phylogenomic databases

ProtClustDBCLSP2511500.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRIR2_IIV6
AccessionPrimary (citable) accession number: Q91FE8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways