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Protein

Probable ribonucleoside-diphosphate reductase small subunit 376L

Gene

IIV6-376L

Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Iron 1By similarity1
Metal bindingi98Iron 1By similarity1
Metal bindingi98Iron 2By similarity1
Metal bindingi101Iron 1By similarity1
Active sitei105By similarity1
Metal bindingi172Iron 2By similarity1
Metal bindingi206Iron 2By similarity1
Metal bindingi209Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribonucleoside-diphosphate reductase small subunit 376L (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
ORF Names:IIV6-376L
OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Taxonomic identifieri176652 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (Asiatic rice borer moth) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
Proteomesi
  • UP000001359 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003769101 – 360Probable ribonucleoside-diphosphate reductase small subunit 376LAdd BLAST360

Proteomic databases

PRIDEiQ91FE8.

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ91FE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00526.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 2 hits.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91FE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLKGRNYY KPFTYPEFYN KWDKHEKSHW LPSEVPMHDD VNDWKNRLND
60 70 80 90 100
NQRDFLTNIF RFFTQGDVDV ASAYYTQYLP FFKLPEVTMM MGGFAGREGV
110 120 130 140 150
HIDAYSYLLE TLGMPEATYK EFLMYEEMKD KQDYIKKFSD SRHILGKGEE
160 170 180 190 200
NLTTEDKEHI AAGIALFSGF TEGMQLFSTF AMLLIFPLNG FMKGMGQIVT
210 220 230 240 250
WSIVDETQHT EGMIELFKVF VEENKTGDQP IRPSVLQETV YKIAKEMVGL
260 270 280 290 300
EEAFIDLVFK KYKDEPINDD NDLETKDNKD FFGLTPQRLK AYIKYIADRR
310 320 330 340 350
LNLMGYKSIF NLEPYPTNPL PELEIMINAP THTNFFENRS TDYANVSTKG
360
TWSEIWNKPQ
Length:360
Mass (Da):42,154
Last modified:December 1, 2001 - v1
Checksum:iD21CAE2D31961145
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303741 Genomic DNA. Translation: AAK82236.1.
RefSeqiNP_149839.1. NC_003038.1.

Genome annotation databases

GeneIDi1733046.
KEGGivg:1733046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303741 Genomic DNA. Translation: AAK82236.1.
RefSeqiNP_149839.1. NC_003038.1.

3D structure databases

ProteinModelPortaliQ91FE8.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ91FE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1733046.
KEGGivg:1733046.

Phylogenomic databases

KOiK00526.

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 2 hits.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRIR2_IIV6
AccessioniPrimary (citable) accession number: Q91FE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.