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Q91F97

- RPB2_IIV6

UniProt

Q91F97 - RPB2_IIV6

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Protein

Probable DNA-directed RNA polymerase II subunit RPB2 homolog

Gene

IIV6-428L

Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Component of the DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit (By similarity).By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi808 – 8081Magnesium; shared with DNA-directed RNA polymerase largest subunitBy similarity
Metal bindingi1137 – 11371ZincBy similarity
Metal bindingi1140 – 11401ZincBy similarity
Metal bindingi1155 – 11551ZincBy similarity
Metal bindingi1158 – 11581ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1137 – 115822C4-typeSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. ribonucleoside binding Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA-directed RNA polymerase II subunit RPB2 homolog (EC:2.7.7.6)
Gene namesi
ORF Names:IIV6-428L
OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Taxonomic identifieri176652 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
ProteomesiUP000001359: Genome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11931193Probable DNA-directed RNA polymerase II subunit RPB2 homologPRO_0000377755Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ91F97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1137 – 115822C4-typeSequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Family and domain databases

Gene3Di2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProiIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007646. RNA_pol_Rpb2_4.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF04566. RNA_pol_Rpb2_4. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91F97 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNMNLNNMN LNNMNLLKEV SEENRLMLLK DYFQTSGLVK HQLETFDHFI
60 70 80 90 100
FHDIKTIIDD EASIIFNGKR SLSSQIKNGA VEEGYNRKES EKIMLKFENV
110 120 130 140 150
FVAKPTITND DTTVRPLYPA EARQKMITYD SFVFVDVLEY VLRDEEEILV
160 170 180 190 200
NKHLRVQIAK IPIMLRSSTC NLYNCTPQER IELGEGIEDP GGYFIINGNE
210 220 230 240 250
RVLIGQLRNA YNRSICFRNK FSEPLTCDMR SMSEETGHSV LIQLRLNDSP
260 270 280 290 300
ISQKRNLKKL DKNGTIDLII SQTKTPIPIS FVFRVLKVAT IDKLKFLIGD
310 320 330 340 350
EEELDKYLIK IVEETSDGGI FDDMEIEISQ EDDFNEENEE STEKKKITQF
360 370 380 390 400
IEQDMFPHLG VSSTHEEKAI LLGKMVRKLL LVNETSINAN KFAQRANDET
410 420 430 440 450
NKTNKTNKMY YTQEDRDNYS NKRVETAGVL CFELFRMLYK RFIKSNINQL
460 470 480 490 500
EKRNRVEMDV ISKNAFITTG LHFSFSTGNW GVQKNNYIRT GVAQIPQNKV
510 520 530 540 550
SFGAFFSYLR RFVIPMGKEG KNTKIRQIHP SSIFFACPSE TPEGQFVGIT
560 570 580 590 600
LNFSMLAEVS IRTSSVVIKE IIEASHQAFK HVHEISLEEN KQFLSKLSII
610 620 630 640 650
FVNGGICGLT SKPQQLLSDV RDLKLKHCLK YDVSAVFIPE LKEVHISSDA
660 670 680 690 700
GRFIRPVLNL QSIKTNGNVM WNSFQNCLEN GHVVYKDAYE IEQSQIAINL
710 720 730 740 750
QDLSRYPTVY DSMEIHASCM LGVMAAQIPF AEHTQSPRLC YQSSMAKQAI
760 770 780 790 800
GNIPSHHVKS DNTTRVMDYV QRPLVTTQIA EMNRFNDFPN GLNAMVAVAI
810 820 830 840 850
YTGFNQEDSI ILNKASIDRG MFHVVTYKTI IVEERKIGVN EKICMPVASV
860 870 880 890 900
RRMNNYSLLE DNPESPYFGV VKVKSFVKRN DVLVGKVITK ISKDGTRQET
910 920 930 940 950
DHSTIVSISE EGKVDRIIRT SKKGILMFKI VIAQQKRPEI GDKFCSAMAQ
960 970 980 990 1000
KGTVGMILEE VDMPFMEDGS IPDMIINPHC LPSRMTINQI MASIMGKTCC
1010 1020 1030 1040 1050
AKNETFGDAS PFQESSLEKP QDKIHALCKE LEECGYNYNG TETMMCGWNG
1060 1070 1080 1090 1100
KKLRAEIFFG PVYYHRLTHM VSDKIFSRAS TNQKRHAITR QPLNGRANEG
1110 1120 1130 1140 1150
GLRIGEMEKD CMLVHGISKF LHEKMFDQSD KFIINLCVPC KSYFKVVKTQ
1160 1170 1180 1190
NGFFCSGCNG IDIVKFNCPF AAKLFFQELT AMGQKLEFKV KNA
Length:1,193
Mass (Da):136,060
Last modified:December 1, 2001 - v1
Checksum:iA0DC39385C6C2519
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303741 Genomic DNA. Translation: AAK82288.1.
RefSeqiNP_149891.1. NC_003038.1.

Genome annotation databases

GeneIDi1733408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303741 Genomic DNA. Translation: AAK82288.1 .
RefSeqi NP_149891.1. NC_003038.1.

3D structure databases

ProteinModelPortali Q91F97.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1733408.

Family and domain databases

Gene3Di 2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProi IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007646. RNA_pol_Rpb2_4.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view ]
PANTHERi PTHR20856. PTHR20856. 1 hit.
Pfami PF04563. RNA_pol_Rpb2_1. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF04566. RNA_pol_Rpb2_4. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
    Jakob N.J., Mueller K., Bahr U., Darai G.
    Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
    Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
    Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.

Entry informationi

Entry nameiRPB2_IIV6
AccessioniPrimary (citable) accession number: Q91F97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3