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Q91F97

- RPB2_IIV6

UniProt

Q91F97 - RPB2_IIV6

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Protein
Probable DNA-directed RNA polymerase II subunit RPB2 homolog
Gene
IIV6-428L
Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit By similarity.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi808 – 8081Magnesium; shared with DNA-directed RNA polymerase largest subunit By similarity
Metal bindingi1137 – 11371Zinc By similarity
Metal bindingi1140 – 11401Zinc By similarity
Metal bindingi1155 – 11551Zinc By similarity
Metal bindingi1158 – 11581Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1137 – 115822C4-type Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. ribonucleoside binding Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA-directed RNA polymerase II subunit RPB2 homolog (EC:2.7.7.6)
Gene namesi
ORF Names:IIV6-428L
OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Taxonomic identifieri176652 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
ProteomesiUP000001359: Genome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11931193Probable DNA-directed RNA polymerase II subunit RPB2 homolog
PRO_0000377755Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ91F97.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Family and domain databases

Gene3Di2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProiIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007646. RNA_pol_Rpb2_4.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF04566. RNA_pol_Rpb2_4. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91F97-1 [UniParc]FASTAAdd to Basket

« Hide

MNNMNLNNMN LNNMNLLKEV SEENRLMLLK DYFQTSGLVK HQLETFDHFI     50
FHDIKTIIDD EASIIFNGKR SLSSQIKNGA VEEGYNRKES EKIMLKFENV 100
FVAKPTITND DTTVRPLYPA EARQKMITYD SFVFVDVLEY VLRDEEEILV 150
NKHLRVQIAK IPIMLRSSTC NLYNCTPQER IELGEGIEDP GGYFIINGNE 200
RVLIGQLRNA YNRSICFRNK FSEPLTCDMR SMSEETGHSV LIQLRLNDSP 250
ISQKRNLKKL DKNGTIDLII SQTKTPIPIS FVFRVLKVAT IDKLKFLIGD 300
EEELDKYLIK IVEETSDGGI FDDMEIEISQ EDDFNEENEE STEKKKITQF 350
IEQDMFPHLG VSSTHEEKAI LLGKMVRKLL LVNETSINAN KFAQRANDET 400
NKTNKTNKMY YTQEDRDNYS NKRVETAGVL CFELFRMLYK RFIKSNINQL 450
EKRNRVEMDV ISKNAFITTG LHFSFSTGNW GVQKNNYIRT GVAQIPQNKV 500
SFGAFFSYLR RFVIPMGKEG KNTKIRQIHP SSIFFACPSE TPEGQFVGIT 550
LNFSMLAEVS IRTSSVVIKE IIEASHQAFK HVHEISLEEN KQFLSKLSII 600
FVNGGICGLT SKPQQLLSDV RDLKLKHCLK YDVSAVFIPE LKEVHISSDA 650
GRFIRPVLNL QSIKTNGNVM WNSFQNCLEN GHVVYKDAYE IEQSQIAINL 700
QDLSRYPTVY DSMEIHASCM LGVMAAQIPF AEHTQSPRLC YQSSMAKQAI 750
GNIPSHHVKS DNTTRVMDYV QRPLVTTQIA EMNRFNDFPN GLNAMVAVAI 800
YTGFNQEDSI ILNKASIDRG MFHVVTYKTI IVEERKIGVN EKICMPVASV 850
RRMNNYSLLE DNPESPYFGV VKVKSFVKRN DVLVGKVITK ISKDGTRQET 900
DHSTIVSISE EGKVDRIIRT SKKGILMFKI VIAQQKRPEI GDKFCSAMAQ 950
KGTVGMILEE VDMPFMEDGS IPDMIINPHC LPSRMTINQI MASIMGKTCC 1000
AKNETFGDAS PFQESSLEKP QDKIHALCKE LEECGYNYNG TETMMCGWNG 1050
KKLRAEIFFG PVYYHRLTHM VSDKIFSRAS TNQKRHAITR QPLNGRANEG 1100
GLRIGEMEKD CMLVHGISKF LHEKMFDQSD KFIINLCVPC KSYFKVVKTQ 1150
NGFFCSGCNG IDIVKFNCPF AAKLFFQELT AMGQKLEFKV KNA 1193
Length:1,193
Mass (Da):136,060
Last modified:December 1, 2001 - v1
Checksum:iA0DC39385C6C2519
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303741 Genomic DNA. Translation: AAK82288.1.
RefSeqiNP_149891.1. NC_003038.1.

Genome annotation databases

GeneIDi1733408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303741 Genomic DNA. Translation: AAK82288.1 .
RefSeqi NP_149891.1. NC_003038.1.

3D structure databases

ProteinModelPortali Q91F97.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1733408.

Family and domain databases

Gene3Di 2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProi IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007646. RNA_pol_Rpb2_4.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view ]
PANTHERi PTHR20856. PTHR20856. 1 hit.
Pfami PF04563. RNA_pol_Rpb2_1. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF04566. RNA_pol_Rpb2_4. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
    Jakob N.J., Mueller K., Bahr U., Darai G.
    Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
    Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
    Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.

Entry informationi

Entry nameiRPB2_IIV6
AccessioniPrimary (citable) accession number: Q91F97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3