Q91F97 (RPB2_IIV6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable DNA-directed RNA polymerase II subunit RPB2 homolog
EC=2.7.7.6

Gene names

ORF Names:

IIV6-428L

Organism

Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) [Reference proteome]

Taxonomic identifier

176652 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Iridovirus

Virus host

Acheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]

Protein attributes

Sequence length	1193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit By similarity.
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Sequence similarities	Belongs to the RNA polymerase beta chain family.

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase
Domain	Zinc-finger
Ligand	Magnesium Metal-binding Zinc
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW ribonucleoside binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1193	1193	Probable DNA-directed RNA polymerase II subunit RPB2 homolog		PRO_0000377755
Regions
	Zinc finger	1137 – 1158	22	C4-type Potential
Sites
	Metal binding	808	1	Magnesium; shared with DNA-directed RNA polymerase largest subunit By similarity
	Metal binding	1137	1	Zinc By similarity
	Metal binding	1140	1	Zinc By similarity
	Metal binding	1155	1	Zinc By similarity
	Metal binding	1158	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91F97 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: A0DC39385C6C2519	FASTA	1,193	136,060
	10 20 30 40 50 60 MNNMNLNNMN LNNMNLLKEV SEENRLMLLK DYFQTSGLVK HQLETFDHFI FHDIKTIIDD 70 80 90 100 110 120 EASIIFNGKR SLSSQIKNGA VEEGYNRKES EKIMLKFENV FVAKPTITND DTTVRPLYPA 130 140 150 160 170 180 EARQKMITYD SFVFVDVLEY VLRDEEEILV NKHLRVQIAK IPIMLRSSTC NLYNCTPQER 190 200 210 220 230 240 IELGEGIEDP GGYFIINGNE RVLIGQLRNA YNRSICFRNK FSEPLTCDMR SMSEETGHSV 250 260 270 280 290 300 LIQLRLNDSP ISQKRNLKKL DKNGTIDLII SQTKTPIPIS FVFRVLKVAT IDKLKFLIGD 310 320 330 340 350 360 EEELDKYLIK IVEETSDGGI FDDMEIEISQ EDDFNEENEE STEKKKITQF IEQDMFPHLG 370 380 390 400 410 420 VSSTHEEKAI LLGKMVRKLL LVNETSINAN KFAQRANDET NKTNKTNKMY YTQEDRDNYS 430 440 450 460 470 480 NKRVETAGVL CFELFRMLYK RFIKSNINQL EKRNRVEMDV ISKNAFITTG LHFSFSTGNW 490 500 510 520 530 540 GVQKNNYIRT GVAQIPQNKV SFGAFFSYLR RFVIPMGKEG KNTKIRQIHP SSIFFACPSE 550 560 570 580 590 600 TPEGQFVGIT LNFSMLAEVS IRTSSVVIKE IIEASHQAFK HVHEISLEEN KQFLSKLSII 610 620 630 640 650 660 FVNGGICGLT SKPQQLLSDV RDLKLKHCLK YDVSAVFIPE LKEVHISSDA GRFIRPVLNL 670 680 690 700 710 720 QSIKTNGNVM WNSFQNCLEN GHVVYKDAYE IEQSQIAINL QDLSRYPTVY DSMEIHASCM 730 740 750 760 770 780 LGVMAAQIPF AEHTQSPRLC YQSSMAKQAI GNIPSHHVKS DNTTRVMDYV QRPLVTTQIA 790 800 810 820 830 840 EMNRFNDFPN GLNAMVAVAI YTGFNQEDSI ILNKASIDRG MFHVVTYKTI IVEERKIGVN 850 860 870 880 890 900 EKICMPVASV RRMNNYSLLE DNPESPYFGV VKVKSFVKRN DVLVGKVITK ISKDGTRQET 910 920 930 940 950 960 DHSTIVSISE EGKVDRIIRT SKKGILMFKI VIAQQKRPEI GDKFCSAMAQ KGTVGMILEE 970 980 990 1000 1010 1020 VDMPFMEDGS IPDMIINPHC LPSRMTINQI MASIMGKTCC AKNETFGDAS PFQESSLEKP 1030 1040 1050 1060 1070 1080 QDKIHALCKE LEECGYNYNG TETMMCGWNG KKLRAEIFFG PVYYHRLTHM VSDKIFSRAS 1090 1100 1110 1120 1130 1140 TNQKRHAITR QPLNGRANEG GLRIGEMEKD CMLVHGISKF LHEKMFDQSD KFIINLCVPC 1150 1160 1170 1180 1190 KSYFKVVKTQ NGFFCSGCNG IDIVKFNCPF AAKLFFQELT AMGQKLEFKV KNA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus." Jakob N.J., Mueller K., Bahr U., Darai G. Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes." Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R. Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF303741 Genomic DNA. Translation: AAK82288.1.
RefSeq	NP_149891.1. NC_003038.1.
3D structure databases
HSSP	HSSP built from PDB template 1TWF based on UniProtKB P08518.
ProteinModelPortal	Q91F97.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1733408.
Phylogenomic databases
ProtClustDB	CLSP2511697.
Family and domain databases
Gene3D	2.40.270.10. 2 hits. 2.40.50.150. 1 hit.
InterPro	IPR015712. DNA-dir_RNA_pol_su2. IPR007120. DNA-dir_RNA_pol_su2_6. IPR007644. RNA_pol_bsu_protrusion. IPR007645. RNA_pol_Rpb2_3. IPR007646. RNA_pol_Rpb2_4. IPR007641. RNA_pol_Rpb2_7. IPR014724. RNA_pol_RPB2_OB-fold. [Graphical view]
PANTHER	PTHR20856. PTHR20856. 1 hit.
Pfam	PF04563. RNA_pol_Rpb2_1. 1 hit. PF04565. RNA_pol_Rpb2_3. 1 hit. PF04566. RNA_pol_Rpb2_4. 1 hit. PF00562. RNA_pol_Rpb2_6. 1 hit. PF04560. RNA_pol_Rpb2_7. 1 hit. [Graphical view]
PROSITE	PS01166. RNA_POL_BETA. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPB2_IIV6

Accession

Primary (citable) accession number: Q91F97

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program