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Q91F97 (RPB2_IIV6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable DNA-directed RNA polymerase II subunit RPB2 homolog

EC=2.7.7.6
Gene names
ORF Names:IIV6-428L
OrganismInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) [Reference proteome]
Taxonomic identifier176652 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
Virus hostAcheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]

Protein attributes

Sequence length1193 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit By similarity.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the RNA polymerase beta chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11931193Probable DNA-directed RNA polymerase II subunit RPB2 homolog
PRO_0000377755

Regions

Zinc finger1137 – 115822C4-type Potential

Sites

Metal binding8081Magnesium; shared with DNA-directed RNA polymerase largest subunit By similarity
Metal binding11371Zinc By similarity
Metal binding11401Zinc By similarity
Metal binding11551Zinc By similarity
Metal binding11581Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91F97 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: A0DC39385C6C2519

FASTA1,193136,060
        10         20         30         40         50         60 
MNNMNLNNMN LNNMNLLKEV SEENRLMLLK DYFQTSGLVK HQLETFDHFI FHDIKTIIDD 

        70         80         90        100        110        120 
EASIIFNGKR SLSSQIKNGA VEEGYNRKES EKIMLKFENV FVAKPTITND DTTVRPLYPA 

       130        140        150        160        170        180 
EARQKMITYD SFVFVDVLEY VLRDEEEILV NKHLRVQIAK IPIMLRSSTC NLYNCTPQER 

       190        200        210        220        230        240 
IELGEGIEDP GGYFIINGNE RVLIGQLRNA YNRSICFRNK FSEPLTCDMR SMSEETGHSV 

       250        260        270        280        290        300 
LIQLRLNDSP ISQKRNLKKL DKNGTIDLII SQTKTPIPIS FVFRVLKVAT IDKLKFLIGD 

       310        320        330        340        350        360 
EEELDKYLIK IVEETSDGGI FDDMEIEISQ EDDFNEENEE STEKKKITQF IEQDMFPHLG 

       370        380        390        400        410        420 
VSSTHEEKAI LLGKMVRKLL LVNETSINAN KFAQRANDET NKTNKTNKMY YTQEDRDNYS 

       430        440        450        460        470        480 
NKRVETAGVL CFELFRMLYK RFIKSNINQL EKRNRVEMDV ISKNAFITTG LHFSFSTGNW 

       490        500        510        520        530        540 
GVQKNNYIRT GVAQIPQNKV SFGAFFSYLR RFVIPMGKEG KNTKIRQIHP SSIFFACPSE 

       550        560        570        580        590        600 
TPEGQFVGIT LNFSMLAEVS IRTSSVVIKE IIEASHQAFK HVHEISLEEN KQFLSKLSII 

       610        620        630        640        650        660 
FVNGGICGLT SKPQQLLSDV RDLKLKHCLK YDVSAVFIPE LKEVHISSDA GRFIRPVLNL 

       670        680        690        700        710        720 
QSIKTNGNVM WNSFQNCLEN GHVVYKDAYE IEQSQIAINL QDLSRYPTVY DSMEIHASCM 

       730        740        750        760        770        780 
LGVMAAQIPF AEHTQSPRLC YQSSMAKQAI GNIPSHHVKS DNTTRVMDYV QRPLVTTQIA 

       790        800        810        820        830        840 
EMNRFNDFPN GLNAMVAVAI YTGFNQEDSI ILNKASIDRG MFHVVTYKTI IVEERKIGVN 

       850        860        870        880        890        900 
EKICMPVASV RRMNNYSLLE DNPESPYFGV VKVKSFVKRN DVLVGKVITK ISKDGTRQET 

       910        920        930        940        950        960 
DHSTIVSISE EGKVDRIIRT SKKGILMFKI VIAQQKRPEI GDKFCSAMAQ KGTVGMILEE 

       970        980        990       1000       1010       1020 
VDMPFMEDGS IPDMIINPHC LPSRMTINQI MASIMGKTCC AKNETFGDAS PFQESSLEKP 

      1030       1040       1050       1060       1070       1080 
QDKIHALCKE LEECGYNYNG TETMMCGWNG KKLRAEIFFG PVYYHRLTHM VSDKIFSRAS 

      1090       1100       1110       1120       1130       1140 
TNQKRHAITR QPLNGRANEG GLRIGEMEKD CMLVHGISKF LHEKMFDQSD KFIINLCVPC 

      1150       1160       1170       1180       1190 
KSYFKVVKTQ NGFFCSGCNG IDIVKFNCPF AAKLFFQELT AMGQKLEFKV KNA 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
Jakob N.J., Mueller K., Bahr U., Darai G.
Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF303741 Genomic DNA. Translation: AAK82288.1.
RefSeqNP_149891.1. NC_003038.1.

3D structure databases

ProteinModelPortalQ91F97.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1733408.

Phylogenomic databases

ProtClustDBCLSP2511697.

Family and domain databases

Gene3D2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007646. RNA_pol_Rpb2_4.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERPTHR20856. PTHR20856. 1 hit.
PfamPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF04566. RNA_pol_Rpb2_4. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPB2_IIV6
AccessionPrimary (citable) accession number: Q91F97
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families