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Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

IIV6-438L

Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Pathwayi: dUMP biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dUMP from dCTP (dUTP route).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (IIV6-438L)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
ORF Names:IIV6-438L
OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Taxonomic identifieri176652 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeBetairidovirinaeIridovirus
Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (Asiatic rice borer moth) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
Proteomesi
  • UP000001359 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003769211 – 296Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST296

Proteomic databases

PRIDEiQ91F87

Structurei

3D structure databases

ProteinModelPortaliQ91F87
SMRiQ91F87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili66 – 102Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

OrthoDBiVOG09000135

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR008181 dUTPase_1
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR00576 dut, 1 hit

Sequencei

Sequence statusi: Complete.

Q91F87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKPTIAIL KNEIDKLKSS FDTEKDEKDT KINHILSVVE GLSKSLSLYI
60 70 80 90 100
EDNDKETTNE EVNIDEIDKN IVKNLEDKVN CLEQDVQYLK NELKKKDADW
110 120 130 140 150
QQKLDLIVHQ FTKQYDSLKS SLLISQKETS VFQSVQNNSN LPNNSNLPIE
160 170 180 190 200
TPILQIKFAA LTEYAQKPKR GSEFSAGIDL RSAYEYLVPA NGNKLIKTDW
210 220 230 240 250
KIQYPDGYFG KICSRSGLSL NHNLEVGAGI VDADYREGVS VVLNNLSPRD
260 270 280 290
FHVAPGDRIA QLVCTPYITP EIVFCKPSDI PDTVRGKNGF GSTGIN
Length:296
Mass (Da):33,257
Last modified:December 1, 2001 - v1
Checksum:i7F4CDD5D131C62B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303741 Genomic DNA Translation: AAK82298.1
RefSeqiNP_149901.1, NC_003038.1

Genome annotation databases

GeneIDi1733373
KEGGivg:1733373

Entry informationi

Entry namei438L_IIV6
AccessioniPrimary (citable) accession number: Q91F87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health