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Q91F87

- 438L_IIV6

UniProt

Q91F87 - 438L_IIV6

Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

IIV6-438L

Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.By similarity

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Pathwayi

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    ORF Names:IIV6-438L
    OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
    Taxonomic identifieri176652 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
    Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
    Chilo suppressalis (striped riceborer) [TaxID: 168631]
    Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
    Gryllus campestris [TaxID: 58607]
    Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
    ProteomesiUP000001359: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Probable deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000376921Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ91F87.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili66 – 10237Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Keywords - Domaini

    Coiled coil

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q91F87-1 [UniParc]FASTAAdd to Basket

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    MDKKPTIAIL KNEIDKLKSS FDTEKDEKDT KINHILSVVE GLSKSLSLYI    50
    EDNDKETTNE EVNIDEIDKN IVKNLEDKVN CLEQDVQYLK NELKKKDADW 100
    QQKLDLIVHQ FTKQYDSLKS SLLISQKETS VFQSVQNNSN LPNNSNLPIE 150
    TPILQIKFAA LTEYAQKPKR GSEFSAGIDL RSAYEYLVPA NGNKLIKTDW 200
    KIQYPDGYFG KICSRSGLSL NHNLEVGAGI VDADYREGVS VVLNNLSPRD 250
    FHVAPGDRIA QLVCTPYITP EIVFCKPSDI PDTVRGKNGF GSTGIN 296
    Length:296
    Mass (Da):33,257
    Last modified:December 1, 2001 - v1
    Checksum:i7F4CDD5D131C62B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303741 Genomic DNA. Translation: AAK82298.1.
    RefSeqiNP_149901.1. NC_003038.1.

    Genome annotation databases

    GeneIDi1733373.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303741 Genomic DNA. Translation: AAK82298.1 .
    RefSeqi NP_149901.1. NC_003038.1.

    3D structure databases

    ProteinModelPortali Q91F87.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1733373.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
      Jakob N.J., Mueller K., Bahr U., Darai G.
      Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
      Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
      Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.

    Entry informationi

    Entry namei438L_IIV6
    AccessioniPrimary (citable) accession number: Q91F87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3