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Q91E96

- VP2_ROTHC

UniProt

Q91E96 - VP2_ROTHC

Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inner capsid protein VP2
    OrganismiRotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
    Taxonomic identifieri31567 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000007664: Genome

    Subcellular locationi

    Virion Curated
    Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

    GO - Cellular componenti

    1. viral inner capsid Source: UniProtKB-KW
    2. viral nucleocapsid Source: InterPro

    Keywords - Cellular componenti

    Capsid protein, Inner capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 884884Inner capsid protein VP2PRO_0000369870Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer Potential. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.By similarityCurated

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9696Interaction with VP1 and VP3By similarityAdd
    BLAST
    Regioni427 – 44721HydrophobicAdd
    BLAST
    Regioni506 – 52621HydrophobicAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi376 – 3794Poly-Ala
    Compositional biasi822 – 8276Poly-Thr

    Domaini

    The N-terminus is involved in VP1 binding.By similarity

    Sequence similaritiesi

    Belongs to the rotavirus VP2 family.Curated

    Family and domain databases

    InterProiIPR007779. Rotavirus_VP2.
    [Graphical view]
    PfamiPF05087. Rota_VP2. 1 hit.
    [Graphical view]
    ProDomiPD008866. Rota_VP2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q91E96-1 [UniParc]FASTAAdd to Basket

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    MISRNRRRNN QQKNIEKEKQ LETIINKEVK ENKDSMKEDK LVVTEESNGD    50
    VTTAKEQSNN INLQKNDLVK EVMNIQNQTL NTVVTENKVE IEEIVKKYIP 100
    SYNTDSLIVK KLTEIQESSA KTYNTLFRLF TPVKSYLYDI NGEKKLSTRW 150
    YWKLLKDDLP AGDYSVRQFF LSLYLNVLEE MPDYIMLRDM AVDNPYSAEA 200
    GKIVDGKSKE ILIELYQDQM TEGYIRRYMS ELRHKISGET NTAKYPAILH 250
    PVDNELNQYF LEHQLIQPLT TRNIAELIPT QLYHDPNYVF NIDAAFLTNS 300
    RFVPPYLTQD RIGLHDGFES IWDSKTHADY VSARRFIPDL TELVDAEKQI 350
    KEMAAHLQLE AITVQVESQF LAGISAAAAN EAFKFIIGSV LSTRTIAVEF 400
    ITSNYMSLAS CMYLMTIMPS EIFLRESLVA MQLAIINTLI YPALGLAQMH 450
    YQAGEVRTPF ELAEMQVANR SIRQWLHHCN TLQFGRQITE GIIHLRFTND 500
    IMTGRIVNLF STMLVALSSQ PFATYPLDYK RSVQRALQLL SNRTAQIADL 550
    TRLIVYNYTT LSACIVMNMH LVGTLTVERI QATSLTSLMM LISNKTVIPE 600
    PSSLFSYFSS NINFLTNYNE QIDNVVAEIM AAYRLNLYQQ KMLMLVTRFV 650
    SKLYIFDAPK IPPDQMYRLR NRLRNIPVER RRADVFRIIM NNRDLIEKTS 700
    ERICQGVLLS YTPMPLTYVE DVGLTNVIND TNSFQIINIE EIEKTGDYSA 750
    ITNALLRDTP IILKGAIPYV TNSSVIDVLS KVDTTVFASI VKDRDISKLK 800
    PIKFIINSDS SEYYLVHNNK WTPTTTTAVY KARSQQFDIQ HSVSMLESNL 850
    FFVVYNDLFK YIKTTTVLPI NAVSYDGARI MQET 884
    Length:884
    Mass (Da):101,673
    Last modified:December 1, 2001 - v1
    Checksum:i3C0C7A4570C69E81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ303139 Genomic RNA. Translation: CAC44890.1.
    RefSeqiYP_392489.1. NC_007546.1.

    Genome annotation databases

    GeneIDi3773136.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ303139 Genomic RNA. Translation: CAC44890.1 .
    RefSeqi YP_392489.1. NC_007546.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3773136.

    Family and domain databases

    InterProi IPR007779. Rotavirus_VP2.
    [Graphical view ]
    Pfami PF05087. Rota_VP2. 1 hit.
    [Graphical view ]
    ProDomi PD008866. Rota_VP2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Human group C rotavirus: completion of the genome sequence and gene coding assignments of a non-cultivatable rotavirus."
      Chen Z., Lambden P.R., Lau J., Caul E.O., Clarke I.N.
      Virus Res. 83:179-187(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP2_ROTHC
    AccessioniPrimary (citable) accession number: Q91E96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3