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Q91E96

- VP2_ROTHC

UniProt

Q91E96 - VP2_ROTHC

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Protein
Inner capsid protein VP2
Gene
N/A
Organism
Rotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Taxonomic identifieri31567 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007664: Genome

Subcellular locationi

Virion Reviewed prediction
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
  2. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 884884Inner capsid protein VP2
PRO_0000369870Add
BLAST

Interactioni

Subunit structurei

Dimer Reviewed prediction. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9696Interaction with VP1 and VP3 By similarity
Add
BLAST
Regioni427 – 44721Hydrophobic
Add
BLAST
Regioni506 – 52621Hydrophobic
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi376 – 3794Poly-Ala
Compositional biasi822 – 8276Poly-Thr

Domaini

The N-terminus is involved in VP1 binding By similarity.

Sequence similaritiesi

Belongs to the rotavirus VP2 family.

Family and domain databases

InterProiIPR007779. Rotavirus_VP2.
[Graphical view]
PfamiPF05087. Rota_VP2. 1 hit.
[Graphical view]
ProDomiPD008866. Rota_VP2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q91E96-1 [UniParc]FASTAAdd to Basket

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MISRNRRRNN QQKNIEKEKQ LETIINKEVK ENKDSMKEDK LVVTEESNGD    50
VTTAKEQSNN INLQKNDLVK EVMNIQNQTL NTVVTENKVE IEEIVKKYIP 100
SYNTDSLIVK KLTEIQESSA KTYNTLFRLF TPVKSYLYDI NGEKKLSTRW 150
YWKLLKDDLP AGDYSVRQFF LSLYLNVLEE MPDYIMLRDM AVDNPYSAEA 200
GKIVDGKSKE ILIELYQDQM TEGYIRRYMS ELRHKISGET NTAKYPAILH 250
PVDNELNQYF LEHQLIQPLT TRNIAELIPT QLYHDPNYVF NIDAAFLTNS 300
RFVPPYLTQD RIGLHDGFES IWDSKTHADY VSARRFIPDL TELVDAEKQI 350
KEMAAHLQLE AITVQVESQF LAGISAAAAN EAFKFIIGSV LSTRTIAVEF 400
ITSNYMSLAS CMYLMTIMPS EIFLRESLVA MQLAIINTLI YPALGLAQMH 450
YQAGEVRTPF ELAEMQVANR SIRQWLHHCN TLQFGRQITE GIIHLRFTND 500
IMTGRIVNLF STMLVALSSQ PFATYPLDYK RSVQRALQLL SNRTAQIADL 550
TRLIVYNYTT LSACIVMNMH LVGTLTVERI QATSLTSLMM LISNKTVIPE 600
PSSLFSYFSS NINFLTNYNE QIDNVVAEIM AAYRLNLYQQ KMLMLVTRFV 650
SKLYIFDAPK IPPDQMYRLR NRLRNIPVER RRADVFRIIM NNRDLIEKTS 700
ERICQGVLLS YTPMPLTYVE DVGLTNVIND TNSFQIINIE EIEKTGDYSA 750
ITNALLRDTP IILKGAIPYV TNSSVIDVLS KVDTTVFASI VKDRDISKLK 800
PIKFIINSDS SEYYLVHNNK WTPTTTTAVY KARSQQFDIQ HSVSMLESNL 850
FFVVYNDLFK YIKTTTVLPI NAVSYDGARI MQET 884
Length:884
Mass (Da):101,673
Last modified:December 1, 2001 - v1
Checksum:i3C0C7A4570C69E81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ303139 Genomic RNA. Translation: CAC44890.1.
RefSeqiYP_392489.1. NC_007546.1.

Genome annotation databases

GeneIDi3773136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ303139 Genomic RNA. Translation: CAC44890.1 .
RefSeqi YP_392489.1. NC_007546.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3773136.

Family and domain databases

InterProi IPR007779. Rotavirus_VP2.
[Graphical view ]
Pfami PF05087. Rota_VP2. 1 hit.
[Graphical view ]
ProDomi PD008866. Rota_VP2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Human group C rotavirus: completion of the genome sequence and gene coding assignments of a non-cultivatable rotavirus."
    Chen Z., Lambden P.R., Lau J., Caul E.O., Clarke I.N.
    Virus Res. 83:179-187(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP2_ROTHC
AccessioniPrimary (citable) accession number: Q91E96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 1, 2001
Last modified: October 16, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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