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Q91E96

- VP2_ROTHC

UniProt

Q91E96 - VP2_ROTHC

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Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Taxonomic identifieri31567 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007664: Genome

Subcellular locationi

Virion Curated
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
  2. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 884884Inner capsid protein VP2PRO_0000369870Add
BLAST

Interactioni

Subunit structurei

Dimer (Potential). Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 (By similarity).By similarityCurated

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9696Interaction with VP1 and VP3By similarityAdd
BLAST
Regioni427 – 44721HydrophobicAdd
BLAST
Regioni506 – 52621HydrophobicAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi376 – 3794Poly-Ala
Compositional biasi822 – 8276Poly-Thr

Domaini

The N-terminus is involved in VP1 binding.By similarity

Sequence similaritiesi

Belongs to the rotavirus VP2 family.Curated

Family and domain databases

InterProiIPR007779. Rotavirus_VP2.
[Graphical view]
PfamiPF05087. Rota_VP2. 1 hit.
[Graphical view]
ProDomiPD008866. Rota_VP2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q91E96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISRNRRRNN QQKNIEKEKQ LETIINKEVK ENKDSMKEDK LVVTEESNGD
60 70 80 90 100
VTTAKEQSNN INLQKNDLVK EVMNIQNQTL NTVVTENKVE IEEIVKKYIP
110 120 130 140 150
SYNTDSLIVK KLTEIQESSA KTYNTLFRLF TPVKSYLYDI NGEKKLSTRW
160 170 180 190 200
YWKLLKDDLP AGDYSVRQFF LSLYLNVLEE MPDYIMLRDM AVDNPYSAEA
210 220 230 240 250
GKIVDGKSKE ILIELYQDQM TEGYIRRYMS ELRHKISGET NTAKYPAILH
260 270 280 290 300
PVDNELNQYF LEHQLIQPLT TRNIAELIPT QLYHDPNYVF NIDAAFLTNS
310 320 330 340 350
RFVPPYLTQD RIGLHDGFES IWDSKTHADY VSARRFIPDL TELVDAEKQI
360 370 380 390 400
KEMAAHLQLE AITVQVESQF LAGISAAAAN EAFKFIIGSV LSTRTIAVEF
410 420 430 440 450
ITSNYMSLAS CMYLMTIMPS EIFLRESLVA MQLAIINTLI YPALGLAQMH
460 470 480 490 500
YQAGEVRTPF ELAEMQVANR SIRQWLHHCN TLQFGRQITE GIIHLRFTND
510 520 530 540 550
IMTGRIVNLF STMLVALSSQ PFATYPLDYK RSVQRALQLL SNRTAQIADL
560 570 580 590 600
TRLIVYNYTT LSACIVMNMH LVGTLTVERI QATSLTSLMM LISNKTVIPE
610 620 630 640 650
PSSLFSYFSS NINFLTNYNE QIDNVVAEIM AAYRLNLYQQ KMLMLVTRFV
660 670 680 690 700
SKLYIFDAPK IPPDQMYRLR NRLRNIPVER RRADVFRIIM NNRDLIEKTS
710 720 730 740 750
ERICQGVLLS YTPMPLTYVE DVGLTNVIND TNSFQIINIE EIEKTGDYSA
760 770 780 790 800
ITNALLRDTP IILKGAIPYV TNSSVIDVLS KVDTTVFASI VKDRDISKLK
810 820 830 840 850
PIKFIINSDS SEYYLVHNNK WTPTTTTAVY KARSQQFDIQ HSVSMLESNL
860 870 880
FFVVYNDLFK YIKTTTVLPI NAVSYDGARI MQET
Length:884
Mass (Da):101,673
Last modified:December 1, 2001 - v1
Checksum:i3C0C7A4570C69E81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ303139 Genomic RNA. Translation: CAC44890.1.
RefSeqiYP_392489.1. NC_007546.1.

Genome annotation databases

GeneIDi3773136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ303139 Genomic RNA. Translation: CAC44890.1 .
RefSeqi YP_392489.1. NC_007546.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3773136.

Family and domain databases

InterProi IPR007779. Rotavirus_VP2.
[Graphical view ]
Pfami PF05087. Rota_VP2. 1 hit.
[Graphical view ]
ProDomi PD008866. Rota_VP2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Human group C rotavirus: completion of the genome sequence and gene coding assignments of a non-cultivatable rotavirus."
    Chen Z., Lambden P.R., Lau J., Caul E.O., Clarke I.N.
    Virus Res. 83:179-187(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP2_ROTHC
AccessioniPrimary (citable) accession number: Q91E96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3