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Q91DE1 (NCAP_EBORE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name=Protein N
Gene names
Name:NP
OrganismReston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus) [Complete proteome]
Taxonomic identifier129003 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541]
Pteropodinae [TaxID: 77225]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length739 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.

Subunit structure

Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 By similarity.

Subcellular location

Virion. Host cytoplasm By similarity.

Domain

This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half By similarity.

Post-translational modification

Phosphorylated and O-glycosylated by host By similarity.

Sequence similarities

Belongs to the filoviruses nucleoprotein family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 739739Nucleoprotein
PRO_0000245051

Regions

Coiled coil334 – 36330 Potential

Sequences

Sequence LengthMass (Da)Tools
Q91DE1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 7F7C5A73168700F2

FASTA73983,463
        10         20         30         40         50         60 
MDRGTRRIWV SQNQGDTDLD YHKILTAGLT VQQGIVRQKI ISVYLVDNLE AMCQLVIQAF 

        70         80         90        100        110        120 
EAGIDFQENA DSFLLMLCLH HAYQGDYKLF LESNAVQYLE GHGFKFELRK KDGVNRLEEL 

       130        140        150        160        170        180 
LPAATSGKNI RRTLAALPEE ETTEANAGQF LSFASLFLPK LVVGEKACLE KVQRQIQVHA 

       190        200        210        220        230        240 
EQGLIQYPTA WQSVGHMMVI FRLMRTNFLI KYLLIHQGMH MVAGHDANDA VIANSVAQAR 

       250        260        270        280        290        300 
FSGLLIVKTV LDHILQKTDQ GVRLHPLART AKVRNEVNAF KAALSSLAKH GEYAPFARLL 

       310        320        330        340        350        360 
NLSGVNNLEH GLYPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA EKQLQQYAES 

       370        380        390        400        410        420 
RELDSLGLDD QERRILMNFH QKKNEISFQQ TNAMVTLRKE RLAKLTEAIT LASRPNLGSR 

       430        440        450        460        470        480 
QDDDNEIPFP GPISNNPDQD HLEDDPRDSR DTIIPNSAID PEDGDFENYN GYHDDEVGTA 

       490        500        510        520        530        540 
GDLVLFDLDD HEDDNKAFEL QDSSPQSQRE IERERLIHPP PGNNKDDNRA SDNNQQSADS 

       550        560        570        580        590        600 
EEQEGQYNRH RGPERTTANR RLSPVHEEDT PIDQGDDDPS SPPPLESDDD DASSSQQDPD 

       610        620        630        640        650        660 
YTAVAPPAPV YRSAEAHEPP HKSSNEPAET SQLNEDPDIG QSKSMQKLGE TYHHLLRTQG 

       670        680        690        700        710        720 
PFEAINYYHM MKDEPVIFST DDGKEYTYPD SLEEAYPPWL TEKERLDNEN RYIYINNQQF 

       730 
FWPVMSPRDK FLAILQHHQ 

« Hide

References

[1]"Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes."
Ikegami T., Calaor A.B., Miranda M.E., Niikura M., Saijo M., Kurane I., Yoshikawa Y., Morikawa S.
Arch. Virol. 146:2021-2027(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB050936 Genomic RNA. Translation: BAB69003.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008609. Ebola_NP.
[Graphical view]
PfamPF05505. Ebola_NP. 1 hit.
[Graphical view]
PIRSFPIRSF003900. N_FiloV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNCAP_EBORE
AccessionPrimary (citable) accession number: Q91DE1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 1, 2001
Last modified: October 16, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families