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Q91DE1

- NCAP_EBORE

UniProt

Q91DE1 - NCAP_EBORE

Protein

Nucleoprotein

Gene

NP

Organism
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome packaging Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Ligandi

    RNA-binding, Viral nucleoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoprotein
    Alternative name(s):
    Nucleocapsid protein
    Short name:
    Protein N
    Gene namesi
    Name:NP
    OrganismiReston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
    Taxonomic identifieri129003 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541]
    Pteropodinae [TaxID: 77225]
    Sus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000002322: Genome

    Subcellular locationi

    Virion. Host cytoplasm By similarity

    GO - Cellular componenti

    1. helical viral capsid Source: UniProtKB-KW
    2. host cell cytoplasm Source: UniProtKB-SubCell
    3. ribonucleoprotein complex Source: UniProtKB-KW
    4. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Helical capsid protein, Host cytoplasm, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 739739NucleoproteinPRO_0000245051Add
    BLAST

    Post-translational modificationi

    Phosphorylated and O-glycosylated by host.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 By similarity.By similarity

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili334 – 36330Sequence AnalysisAdd
    BLAST

    Domaini

    This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half.By similarity

    Sequence similaritiesi

    Belongs to the filoviruses nucleoprotein family.Curated

    Keywords - Domaini

    Coiled coil

    Family and domain databases

    InterProiIPR008609. Ebola_NP.
    [Graphical view]
    PfamiPF05505. Ebola_NP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003900. N_FiloV. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q91DE1-1 [UniParc]FASTAAdd to Basket

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    MDRGTRRIWV SQNQGDTDLD YHKILTAGLT VQQGIVRQKI ISVYLVDNLE    50
    AMCQLVIQAF EAGIDFQENA DSFLLMLCLH HAYQGDYKLF LESNAVQYLE 100
    GHGFKFELRK KDGVNRLEEL LPAATSGKNI RRTLAALPEE ETTEANAGQF 150
    LSFASLFLPK LVVGEKACLE KVQRQIQVHA EQGLIQYPTA WQSVGHMMVI 200
    FRLMRTNFLI KYLLIHQGMH MVAGHDANDA VIANSVAQAR FSGLLIVKTV 250
    LDHILQKTDQ GVRLHPLART AKVRNEVNAF KAALSSLAKH GEYAPFARLL 300
    NLSGVNNLEH GLYPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA 350
    EKQLQQYAES RELDSLGLDD QERRILMNFH QKKNEISFQQ TNAMVTLRKE 400
    RLAKLTEAIT LASRPNLGSR QDDDNEIPFP GPISNNPDQD HLEDDPRDSR 450
    DTIIPNSAID PEDGDFENYN GYHDDEVGTA GDLVLFDLDD HEDDNKAFEL 500
    QDSSPQSQRE IERERLIHPP PGNNKDDNRA SDNNQQSADS EEQEGQYNRH 550
    RGPERTTANR RLSPVHEEDT PIDQGDDDPS SPPPLESDDD DASSSQQDPD 600
    YTAVAPPAPV YRSAEAHEPP HKSSNEPAET SQLNEDPDIG QSKSMQKLGE 650
    TYHHLLRTQG PFEAINYYHM MKDEPVIFST DDGKEYTYPD SLEEAYPPWL 700
    TEKERLDNEN RYIYINNQQF FWPVMSPRDK FLAILQHHQ 739
    Length:739
    Mass (Da):83,463
    Last modified:December 1, 2001 - v1
    Checksum:i7F7C5A73168700F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050936 Genomic RNA. Translation: BAB69003.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050936 Genomic RNA. Translation: BAB69003.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR008609. Ebola_NP.
    [Graphical view ]
    Pfami PF05505. Ebola_NP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003900. N_FiloV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes."
      Ikegami T., Calaor A.B., Miranda M.E., Niikura M., Saijo M., Kurane I., Yoshikawa Y., Morikawa S.
      Arch. Virol. 146:2021-2027(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNCAP_EBORE
    AccessioniPrimary (citable) accession number: Q91DE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3