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Q91DE1

- NCAP_EBORE

UniProt

Q91DE1 - NCAP_EBORE

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Protein
Nucleoprotein
Gene
NP
Organism
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome packaging Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:NP
OrganismiReston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
Taxonomic identifieri129003 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541]
Pteropodinae [TaxID: 77225]
Sus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000002322: Genome

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. helical viral capsid Source: UniProtKB-KW
  2. host cell cytoplasm Source: UniProtKB-SubCell
  3. ribonucleoprotein complex Source: UniProtKB-KW
  4. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Nucleoprotein
PRO_0000245051Add
BLAST

Post-translational modificationi

Phosphorylated and O-glycosylated by host By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 By similarity.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili334 – 36330 Reviewed prediction
Add
BLAST

Domaini

This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half By similarity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR008609. Ebola_NP.
[Graphical view]
PfamiPF05505. Ebola_NP. 1 hit.
[Graphical view]
PIRSFiPIRSF003900. N_FiloV. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91DE1-1 [UniParc]FASTAAdd to Basket

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MDRGTRRIWV SQNQGDTDLD YHKILTAGLT VQQGIVRQKI ISVYLVDNLE    50
AMCQLVIQAF EAGIDFQENA DSFLLMLCLH HAYQGDYKLF LESNAVQYLE 100
GHGFKFELRK KDGVNRLEEL LPAATSGKNI RRTLAALPEE ETTEANAGQF 150
LSFASLFLPK LVVGEKACLE KVQRQIQVHA EQGLIQYPTA WQSVGHMMVI 200
FRLMRTNFLI KYLLIHQGMH MVAGHDANDA VIANSVAQAR FSGLLIVKTV 250
LDHILQKTDQ GVRLHPLART AKVRNEVNAF KAALSSLAKH GEYAPFARLL 300
NLSGVNNLEH GLYPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA 350
EKQLQQYAES RELDSLGLDD QERRILMNFH QKKNEISFQQ TNAMVTLRKE 400
RLAKLTEAIT LASRPNLGSR QDDDNEIPFP GPISNNPDQD HLEDDPRDSR 450
DTIIPNSAID PEDGDFENYN GYHDDEVGTA GDLVLFDLDD HEDDNKAFEL 500
QDSSPQSQRE IERERLIHPP PGNNKDDNRA SDNNQQSADS EEQEGQYNRH 550
RGPERTTANR RLSPVHEEDT PIDQGDDDPS SPPPLESDDD DASSSQQDPD 600
YTAVAPPAPV YRSAEAHEPP HKSSNEPAET SQLNEDPDIG QSKSMQKLGE 650
TYHHLLRTQG PFEAINYYHM MKDEPVIFST DDGKEYTYPD SLEEAYPPWL 700
TEKERLDNEN RYIYINNQQF FWPVMSPRDK FLAILQHHQ 739
Length:739
Mass (Da):83,463
Last modified:December 1, 2001 - v1
Checksum:i7F7C5A73168700F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB050936 Genomic RNA. Translation: BAB69003.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB050936 Genomic RNA. Translation: BAB69003.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR008609. Ebola_NP.
[Graphical view ]
Pfami PF05505. Ebola_NP. 1 hit.
[Graphical view ]
PIRSFi PIRSF003900. N_FiloV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes."
    Ikegami T., Calaor A.B., Miranda M.E., Niikura M., Saijo M., Kurane I., Yoshikawa Y., Morikawa S.
    Arch. Virol. 146:2021-2027(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNCAP_EBORE
AccessioniPrimary (citable) accession number: Q91DE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 1, 2001
Last modified: October 16, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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