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Q91DD6

- VP30_EBORE

UniProt

Q91DD6 - VP30_EBORE

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Protein
Minor nucleoprotein VP30
Gene
VP30
Organism
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri72 – 9019C3H1-type; atypical
Add
BLAST

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

Metal-binding, RNA-binding, Viral nucleoprotein, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Minor nucleoprotein VP30
Alternative name(s):
Transcription activator VP30
Gene namesi
Name:VP30
OrganismiReston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
Taxonomic identifieri129003 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541]
Pteropodinae [TaxID: 77225]
Sus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000002322: Genome

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Minor nucleoprotein VP30
PRO_0000245071Add
BLAST

Post-translational modificationi

Phosphorylated by host. Phosphorylation negatively regulates the transcription activation By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homohexamer or homodimer. Interacts with the nucleoprotein By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ91DD6.
SMRiQ91DD6. Positions 142-266.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4444Intrinsically disordered Reviewed prediction
Add
BLAST
Regioni26 – 4015RNA-binding By similarity
Add
BLAST
Regioni94 – 11219Oligomerization By similarity
Add
BLAST
Regioni121 – 14020Intrinsically disordered Reviewed prediction
Add
BLAST
Regioni180 – 19718Interaction with the nucleoprotein By similarity
Add
BLAST
Regioni268 – 28720Intrinsically disordered Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR014459. VP30_FiloV.
[Graphical view]
PfamiPF11507. Transcript_VP30. 1 hit.
[Graphical view]
PIRSFiPIRSF011356. VP30_FiloV. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91DD6-1 [UniParc]FASTAAdd to Basket

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MEHSRERGRS SNMRHNSREP YENPSRSRSL SRDPNQVDRR QPRSASQIRV    50
PNLFHRKKTD ALIVPPAPKD ICPTLKKGFL CDSKFCKKDH QLDSLNDHEL 100
LLLIARRTCG IIESNSQITS PKDMRLANPT AEDFSQGNSP KLTLAVLLQI 150
AEHWATRDLR QIEDSKLRAL LTLCAVLTRK FSKSQLGLLC ETHLRHEGLG 200
QDQADSVLEV YQRLHSDKGG NFEAALWQQW DRQSLIMFIS AFLNIALQTP 250
CESSSVVVSG LATLYPAQDN STPSEATNDT TWSSTVE 287
Length:287
Mass (Da):32,389
Last modified:December 1, 2001 - v1
Checksum:iF4CFBDA604A77920
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB050936 Genomic RNA. Translation: BAB69008.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB050936 Genomic RNA. Translation: BAB69008.1 .

3D structure databases

ProteinModelPortali Q91DD6.
SMRi Q91DD6. Positions 142-266.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR014459. VP30_FiloV.
[Graphical view ]
Pfami PF11507. Transcript_VP30. 1 hit.
[Graphical view ]
PIRSFi PIRSF011356. VP30_FiloV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes."
    Ikegami T., Calaor A.B., Miranda M.E., Niikura M., Saijo M., Kurane I., Yoshikawa Y., Morikawa S.
    Arch. Virol. 146:2021-2027(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP30_EBORE
AccessioniPrimary (citable) accession number: Q91DD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 1, 2001
Last modified: March 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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