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Q91DD6

- VP30_EBORE

UniProt

Q91DD6 - VP30_EBORE

Protein

Minor nucleoprotein VP30

Gene

VP30

Organism
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri72 – 9019C3H1-type; atypicalAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    Metal-binding, RNA-binding, Viral nucleoprotein, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Minor nucleoprotein VP30
    Alternative name(s):
    Transcription activator VP30
    Gene namesi
    Name:VP30
    OrganismiReston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
    Taxonomic identifieri129003 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541]
    Pteropodinae [TaxID: 77225]
    Sus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000002322: Genome

    Subcellular locationi

    Virion. Host cytoplasm By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Host cytoplasm, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Minor nucleoprotein VP30PRO_0000245071Add
    BLAST

    Post-translational modificationi

    Phosphorylated by host. Phosphorylation negatively regulates the transcription activation By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homohexamer or homodimer. Interacts with the nucleoprotein By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ91DD6.
    SMRiQ91DD6. Positions 142-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 4444Intrinsically disorderedSequence AnalysisAdd
    BLAST
    Regioni26 – 4015RNA-bindingBy similarityAdd
    BLAST
    Regioni94 – 11219OligomerizationBy similarityAdd
    BLAST
    Regioni121 – 14020Intrinsically disorderedSequence AnalysisAdd
    BLAST
    Regioni180 – 19718Interaction with the nucleoproteinBy similarityAdd
    BLAST
    Regioni268 – 28720Intrinsically disorderedSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C3H1-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri72 – 9019C3H1-type; atypicalAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Family and domain databases

    InterProiIPR014459. VP30_FiloV.
    [Graphical view]
    PfamiPF11507. Transcript_VP30. 1 hit.
    [Graphical view]
    PIRSFiPIRSF011356. VP30_FiloV. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q91DD6-1 [UniParc]FASTAAdd to Basket

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    MEHSRERGRS SNMRHNSREP YENPSRSRSL SRDPNQVDRR QPRSASQIRV    50
    PNLFHRKKTD ALIVPPAPKD ICPTLKKGFL CDSKFCKKDH QLDSLNDHEL 100
    LLLIARRTCG IIESNSQITS PKDMRLANPT AEDFSQGNSP KLTLAVLLQI 150
    AEHWATRDLR QIEDSKLRAL LTLCAVLTRK FSKSQLGLLC ETHLRHEGLG 200
    QDQADSVLEV YQRLHSDKGG NFEAALWQQW DRQSLIMFIS AFLNIALQTP 250
    CESSSVVVSG LATLYPAQDN STPSEATNDT TWSSTVE 287
    Length:287
    Mass (Da):32,389
    Last modified:December 1, 2001 - v1
    Checksum:iF4CFBDA604A77920
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050936 Genomic RNA. Translation: BAB69008.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050936 Genomic RNA. Translation: BAB69008.1 .

    3D structure databases

    ProteinModelPortali Q91DD6.
    SMRi Q91DD6. Positions 142-266.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR014459. VP30_FiloV.
    [Graphical view ]
    Pfami PF11507. Transcript_VP30. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF011356. VP30_FiloV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes."
      Ikegami T., Calaor A.B., Miranda M.E., Niikura M., Saijo M., Kurane I., Yoshikawa Y., Morikawa S.
      Arch. Virol. 146:2021-2027(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP30_EBORE
    AccessioniPrimary (citable) accession number: Q91DD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3