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Q91DD5

- VP24_EBORE

UniProt

Q91DD5 - VP24_EBORE

Protein

Membrane-associated protein VP24

Gene

VP24

Organism
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. evasion or tolerance by virus of host immune response Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Interferon antiviral system evasion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane-associated protein VP24
    Gene namesi
    Name:VP24
    OrganismiReston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
    Taxonomic identifieri129003 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541]
    Pteropodinae [TaxID: 77225]
    Sus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000002322: Genome

    Subcellular locationi

    Virion membrane By similarity; Peripheral membrane protein By similarity. Host cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Host endomembrane system By similarity; Peripheral membrane protein By similarity
    Note: In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place By similarity.By similarity

    GO - Cellular componenti

    1. host cell endomembrane system Source: UniProtKB-SubCell
    2. host cell plasma membrane Source: UniProtKB-SubCell
    3. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 251251Membrane-associated protein VP24PRO_0000245067Add
    BLAST

    Interactioni

    Subunit structurei

    Binds to host importin alpha-1/KPNA1.By similarity

    Structurei

    Secondary structure

    1
    251
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi14 – 2714
    Beta strandi30 – 334
    Beta strandi35 – 428
    Beta strandi45 – 506
    Helixi54 – 607
    Helixi71 – 755
    Helixi77 – 804
    Helixi90 – 10617
    Helixi114 – 12815
    Helixi139 – 1424
    Helixi147 – 16519
    Beta strandi178 – 1825
    Beta strandi187 – 1937
    Beta strandi196 – 2027
    Beta strandi218 – 2225
    Helixi224 – 2307

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4D9OX-ray2.00A/B11-231[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR009433. Filo_VP24.
    [Graphical view]
    PfamiPF06389. Filo_VP24. 1 hit.
    [Graphical view]
    PIRSFiPIRSF011355. VP24. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q91DD5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKATGRYNL VPPKKDMEKG VIFSDLCNFL ITQTLQGWKV YWAGIEFDVS    50
    QKGMALLTRL KTNDFAPAWA MTRNLFPHLF QNPNSVIQSP IWALRVILAA 100
    GLQDQLLDHS LVEPLTGALG LISDWLLTTT STHFNLRTRS VKDQLSLRML 150
    SLIRSNILQF INKLDALHVV NYNGLLSSIE IGTSTHTIII TRTNMGFLVE 200
    VQEPDKSAMN SKRPGPVKFS LLHESAFKPF TRVPQSGMQS LIMEFNSLLA 250
    I 251
    Length:251
    Mass (Da):28,169
    Last modified:December 1, 2001 - v1
    Checksum:iDB8F144CA8FB2509
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050936 Genomic RNA. Translation: BAB69009.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050936 Genomic RNA. Translation: BAB69009.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4D9O X-ray 2.00 A/B 11-231 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR009433. Filo_VP24.
    [Graphical view ]
    Pfami PF06389. Filo_VP24. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF011355. VP24. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes."
      Ikegami T., Calaor A.B., Miranda M.E., Niikura M., Saijo M., Kurane I., Yoshikawa Y., Morikawa S.
      Arch. Virol. 146:2021-2027(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP24_EBORE
    AccessioniPrimary (citable) accession number: Q91DD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3