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Q91DD5 (VP24_EBORE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.

Subunit structure

Binds to host importin alpha-1/KPNA1 By similarity.

Subcellular location

Virion membrane; Peripheral membrane protein By similarity. Host cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Host endomembrane system; Peripheral membrane protein By similarity. Note: In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place By similarity.

Sequence similarities

Belongs to the filoviridae membrane-associated protein VP24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Membrane-associated protein VP24
PRO_0000245067

Secondary structure

................................. 251
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q91DD5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: DB8F144CA8FB2509

FASTA25128,169
        10         20         30         40         50         60 
MAKATGRYNL VPPKKDMEKG VIFSDLCNFL ITQTLQGWKV YWAGIEFDVS QKGMALLTRL 

        70         80         90        100        110        120 
KTNDFAPAWA MTRNLFPHLF QNPNSVIQSP IWALRVILAA GLQDQLLDHS LVEPLTGALG 

       130        140        150        160        170        180 
LISDWLLTTT STHFNLRTRS VKDQLSLRML SLIRSNILQF INKLDALHVV NYNGLLSSIE 

       190        200        210        220        230        240 
IGTSTHTIII TRTNMGFLVE VQEPDKSAMN SKRPGPVKFS LLHESAFKPF TRVPQSGMQS 

       250 
LIMEFNSLLA I 

« Hide

References

[1]"Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes."
Ikegami T., Calaor A.B., Miranda M.E., Niikura M., Saijo M., Kurane I., Yoshikawa Y., Morikawa S.
Arch. Virol. 146:2021-2027(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB050936 Genomic RNA. Translation: BAB69009.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4D9OX-ray2.00A/B11-231[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR009433. Filo_VP24.
[Graphical view]
PfamPF06389. Filo_VP24. 1 hit.
[Graphical view]
PIRSFPIRSF011355. VP24. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVP24_EBORE
AccessionPrimary (citable) accession number: Q91DD5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 1, 2001
Last modified: April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references