Q91CL9 (CATV_NPVAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Viral cathepsin
Short name=V-cath
EC=3.4.22.50

Alternative name(s):
Cysteine proteinase
Short name=CP

Gene names

Name:

VCATH

Organism

Antheraea pernyi nuclear polyhedrosis virus (ApNPV)

Taxonomic identifier

161494 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Baculoviridae › Alphabaculovirus

Virus host

Antheraea pernyi (Chinese oak silk moth) [TaxID: 7119]

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system By similarity.
Catalytic activity	Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.
Post-translational modification	Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide By similarity.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Propeptide	17 – 113	97	Activation peptide Potential		PRO_0000322203
	Chain	114 – 324	211	Viral cathepsin		PRO_0000050574
Sites
	Active site	137	1	By similarity
	Active site	270	1	By similarity
	Active site	290	1	By similarity
Amino acid modifications
	Glycosylation	159	1	N-linked (GlcNAc...); by host Potential
	Disulfide bond	134 ↔ 175		By similarity
	Disulfide bond	168 ↔ 208		By similarity
	Disulfide bond	263 ↔ 311		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91CL9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: AA1D457183DEC547	FASTA	324	36,770
	10 20 30 40 50 60 MNKIVLYLLV YGATLGAAYD LLKAPSYFEE FLHKFNKNYS SESEKLRRFK IFQHNLEEII 70 80 90 100 110 120 NKNQNDTSAQ YEINKFSDLS KDETISKYTG LSLPLQKQNF CEVVVLDRPP DKGPLEFDWR 130 140 150 160 170 180 RLNKVTSVKN QGMCGACWAF ATLGSLESQF AIKHDQLINL SEQQLIDCDF VDVGCDGGLL 190 200 210 220 230 240 HTAYEAVMNM GGIQAENDYP YEANNGPCRV NAAKFVVRVK KCYRYVTLFE EKLKDLLRIV 250 260 270 280 290 300 GPIPVAIDAS DIVGYKRGII RYCENHGLNH AVLLVGYGVE NGIPFWILKN TWGADWGEQG 310 320 YFRVQQNINA CGIKNELPSS AEIY

References

[1]	"Genome mapping and gene analysis of Antheraea pernyi nucleopolyhedrovirus for improvement of baculovirus expression vector system." Huang Y.J., Kobayashi J., Yoshimura T. J. Biosci. Bioeng. 93:183-191(2002) [PubMed: 16233185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB072731 Genomic DNA. Translation: BAB69773.1.
RefSeq	YP_611001.1. NC_008035.3.
3D structure databases
ProteinModelPortal	Q91CL9.
ModBase	Search...
Protein family/group databases
MEROPS	C01.083.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5141489.
Phylogenomic databases
ProtClustDB	CLSP2509984.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHER	PTHR12411. Peptidase_C1A. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
SMART	SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATV_NPVAP

Accession

Primary (citable) accession number: Q91CL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	December 1, 2001
Last modified:	November 16, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program