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Q91998

- BRN3_CHICK

UniProt

Q91998 - BRN3_CHICK

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Protein
Brain-specific homeobox/POU domain protein 3
Gene
BRN3
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in specifying terminally differentiated neuronal phenotypes By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi277 – 33660Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific homeobox/POU domain protein 3
Short name:
Brain-3
Short name:
Brn-3
Gene namesi
Name:BRN3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Brain-specific homeobox/POU domain protein 3
PRO_0000100744Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ91998.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 25978POU-specific
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi55 – 6511POU-IV box
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG289030.
GeneTreeiENSGT00750000117482.
HOGENOMiHOG000116305.
HOVERGENiHBG031829.
InParanoidiQ91998.
KOiK09366.
PhylomeDBiQ91998.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91998-1 [UniParc]FASTAAdd to Basket

« Hide

MMSMNSKQAF SMHPILHEPK YPHLHTSSEA IRRACLPAPQ IQGNIFAGFD    50
ETLLRGAEAL AAVDIVSQKT HPFKPDATYH TMSSVSCTPT SSSVHLHHPS 100
VLTTHHPHHH HHQPAQGLEG ELLDHLNSAL PLGGVPGPDV GSTPSHPHSH 150
MSAINHMAHH SQPMNMSHPH GLASHAVISG PETETDPREL ESFAERFKQR 200
RIKLGVTQAD VGSALANLKI PGVGCLSQST ICRFESLTLS HNNMVALKPI 250
LEAWLEEAER AQREKMTKPE IYTGGDKKRK RTSIAAPEKR SLEAYFAVQP 300
RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRMKFSAT Y 341
Length:341
Mass (Da):37,773
Last modified:November 1, 1996 - v1
Checksum:i6A4C741C88C07D5F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91998 mRNA. Translation: CAA63049.1.
X91997 Genomic DNA. Translation: CAA63048.1.
RefSeqiNP_990090.1. NM_204759.1.
UniGeneiGga.282.

Genome annotation databases

EnsembliENSGALT00000045448; ENSGALP00000041494; ENSGALG00000026243.
GeneIDi395521.
KEGGigga:395521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91998 mRNA. Translation: CAA63049.1 .
X91997 Genomic DNA. Translation: CAA63048.1 .
RefSeqi NP_990090.1. NM_204759.1.
UniGenei Gga.282.

3D structure databases

ProteinModelPortali Q91998.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000045448 ; ENSGALP00000041494 ; ENSGALG00000026243 .
GeneIDi 395521.
KEGGi gga:395521.

Organism-specific databases

CTDi 5459.

Phylogenomic databases

eggNOGi NOG289030.
GeneTreei ENSGT00750000117482.
HOGENOMi HOG000116305.
HOVERGENi HBG031829.
InParanoidi Q91998.
KOi K09366.
PhylomeDBi Q91998.

Miscellaneous databases

NextBioi 20815599.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a chicken homologue in the Brn-3 subfamily of POU-transcription factors."
    Lindeberg J.K., Klint P., Williams R., Ebendal T.
    Brain Res. Dev. Brain Res. 100:169-182(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Spinal ganglion.

Entry informationi

Entry nameiBRN3_CHICK
AccessioniPrimary (citable) accession number: Q91998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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