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Protein

Brain-specific homeobox/POU domain protein 3

Gene

BRN3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in specifying terminally differentiated neuronal phenotypes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi277 – 33660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific homeobox/POU domain protein 3
Short name:
Brain-3
Short name:
Brn-3
Gene namesi
Name:BRN3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Brain-specific homeobox/POU domain protein 3PRO_0000100744Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022918.

Structurei

3D structure databases

ProteinModelPortaliQ91998.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 25978POU-specificPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi55 – 6511POU-IV boxAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG289030.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116305.
HOVERGENiHBG031829.
InParanoidiQ91998.
KOiK09366.
OMAiFNGGDKK.
PhylomeDBiQ91998.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSMNSKQAF SMHPILHEPK YPHLHTSSEA IRRACLPAPQ IQGNIFAGFD
60 70 80 90 100
ETLLRGAEAL AAVDIVSQKT HPFKPDATYH TMSSVSCTPT SSSVHLHHPS
110 120 130 140 150
VLTTHHPHHH HHQPAQGLEG ELLDHLNSAL PLGGVPGPDV GSTPSHPHSH
160 170 180 190 200
MSAINHMAHH SQPMNMSHPH GLASHAVISG PETETDPREL ESFAERFKQR
210 220 230 240 250
RIKLGVTQAD VGSALANLKI PGVGCLSQST ICRFESLTLS HNNMVALKPI
260 270 280 290 300
LEAWLEEAER AQREKMTKPE IYTGGDKKRK RTSIAAPEKR SLEAYFAVQP
310 320 330 340
RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRMKFSAT Y
Length:341
Mass (Da):37,773
Last modified:November 1, 1996 - v1
Checksum:i6A4C741C88C07D5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91998 mRNA. Translation: CAA63049.1.
X91997 Genomic DNA. Translation: CAA63048.1.
RefSeqiNP_990090.1. NM_204759.1.
UniGeneiGga.282.

Genome annotation databases

EnsembliENSGALT00000045448; ENSGALP00000041494; ENSGALG00000026243.
GeneIDi395521.
KEGGigga:395521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91998 mRNA. Translation: CAA63049.1.
X91997 Genomic DNA. Translation: CAA63048.1.
RefSeqiNP_990090.1. NM_204759.1.
UniGeneiGga.282.

3D structure databases

ProteinModelPortaliQ91998.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022918.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000045448; ENSGALP00000041494; ENSGALG00000026243.
GeneIDi395521.
KEGGigga:395521.

Organism-specific databases

CTDi5459.

Phylogenomic databases

eggNOGiNOG289030.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116305.
HOVERGENiHBG031829.
InParanoidiQ91998.
KOiK09366.
OMAiFNGGDKK.
PhylomeDBiQ91998.

Miscellaneous databases

NextBioi20815599.
PROiQ91998.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a chicken homologue in the Brn-3 subfamily of POU-transcription factors."
    Lindeberg J.K., Klint P., Williams R., Ebendal T.
    Brain Res. Dev. Brain Res. 100:169-182(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Spinal ganglion.

Entry informationi

Entry nameiBRN3_CHICK
AccessioniPrimary (citable) accession number: Q91998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.