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Protein

Brain-specific homeobox/POU domain protein 3

Gene

BRN3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in specifying terminally differentiated neuronal phenotypes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi277 – 336HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific homeobox/POU domain protein 3
Short name:
Brain-3
Short name:
Brn-3
Gene namesi
Name:BRN3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007441 – 341Brain-specific homeobox/POU domain protein 3Add BLAST341

Proteomic databases

PaxDbiQ91998
PRIDEiQ91998

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022918

Structurei

3D structure databases

ProteinModelPortaliQ91998
SMRiQ91998
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 259POU-specificPROSITE-ProRule annotationAdd BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi55 – 65POU-IV boxAdd BLAST11

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG1168 Eukaryota
ENOG410XPNX LUCA
GeneTreeiENSGT00760000118935
HOGENOMiHOG000116305
HOVERGENiHBG031829
InParanoidiQ91998
KOiK09366
OMAiIVAQKSH
OrthoDBiEOG091G0WBK
PhylomeDBiQ91998

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00093 HTH_XRE, 1 hit
InterProiView protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q91998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSMNSKQAF SMHPILHEPK YPHLHTSSEA IRRACLPAPQ IQGNIFAGFD
60 70 80 90 100
ETLLRGAEAL AAVDIVSQKT HPFKPDATYH TMSSVSCTPT SSSVHLHHPS
110 120 130 140 150
VLTTHHPHHH HHQPAQGLEG ELLDHLNSAL PLGGVPGPDV GSTPSHPHSH
160 170 180 190 200
MSAINHMAHH SQPMNMSHPH GLASHAVISG PETETDPREL ESFAERFKQR
210 220 230 240 250
RIKLGVTQAD VGSALANLKI PGVGCLSQST ICRFESLTLS HNNMVALKPI
260 270 280 290 300
LEAWLEEAER AQREKMTKPE IYTGGDKKRK RTSIAAPEKR SLEAYFAVQP
310 320 330 340
RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRMKFSAT Y
Length:341
Mass (Da):37,773
Last modified:November 1, 1996 - v1
Checksum:i6A4C741C88C07D5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91998 mRNA Translation: CAA63049.1
X91997 Genomic DNA Translation: CAA63048.1
RefSeqiNP_990090.1, NM_204759.1
UniGeneiGga.282

Genome annotation databases

EnsembliENSGALT00000061255; ENSGALP00000055381; ENSGALG00000034567
GeneIDi395521
KEGGigga:395521

Similar proteinsi

Entry informationi

Entry nameiBRN3_CHICK
AccessioniPrimary (citable) accession number: Q91998
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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