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Protein

Brain-specific homeobox/POU domain protein 3

Gene

BRN3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in specifying terminally differentiated neuronal phenotypes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi277 – 336HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific homeobox/POU domain protein 3
Short name:
Brain-3
Short name:
Brn-3
Gene namesi
Name:BRN3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007441 – 341Brain-specific homeobox/POU domain protein 3Add BLAST341

Proteomic databases

PaxDbiQ91998.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022918.

Structurei

3D structure databases

ProteinModelPortaliQ91998.
SMRiQ91998.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 259POU-specificPROSITE-ProRule annotationAdd BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi55 – 65POU-IV boxAdd BLAST11

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG1168. Eukaryota.
ENOG410XPNX. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116305.
HOVERGENiHBG031829.
InParanoidiQ91998.
KOiK09366.
OMAiIVAQKSH.
OrthoDBiEOG091G0WBK.
PhylomeDBiQ91998.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSMNSKQAF SMHPILHEPK YPHLHTSSEA IRRACLPAPQ IQGNIFAGFD
60 70 80 90 100
ETLLRGAEAL AAVDIVSQKT HPFKPDATYH TMSSVSCTPT SSSVHLHHPS
110 120 130 140 150
VLTTHHPHHH HHQPAQGLEG ELLDHLNSAL PLGGVPGPDV GSTPSHPHSH
160 170 180 190 200
MSAINHMAHH SQPMNMSHPH GLASHAVISG PETETDPREL ESFAERFKQR
210 220 230 240 250
RIKLGVTQAD VGSALANLKI PGVGCLSQST ICRFESLTLS HNNMVALKPI
260 270 280 290 300
LEAWLEEAER AQREKMTKPE IYTGGDKKRK RTSIAAPEKR SLEAYFAVQP
310 320 330 340
RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRMKFSAT Y
Length:341
Mass (Da):37,773
Last modified:November 1, 1996 - v1
Checksum:i6A4C741C88C07D5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91998 mRNA. Translation: CAA63049.1.
X91997 Genomic DNA. Translation: CAA63048.1.
RefSeqiNP_990090.1. NM_204759.1.
UniGeneiGga.282.

Genome annotation databases

EnsembliENSGALT00000061255; ENSGALP00000055381; ENSGALG00000034567.
GeneIDi395521.
KEGGigga:395521.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBRN3_CHICK
AccessioniPrimary (citable) accession number: Q91998
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families