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Q91998 (BRN3_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brain-specific homeobox/POU domain protein 3

Short name=Brain-3
Short name=Brn-3
Gene names
Name:BRN3
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in specifying terminally differentiated neuronal phenotypes By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the POU transcription factor family. Class-4 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Brain-specific homeobox/POU domain protein 3
PRO_0000100744

Regions

Domain182 – 25978POU-specific
DNA binding277 – 33660Homeobox
Motif55 – 6511POU-IV box

Sequences

Sequence LengthMass (Da)Tools
Q91998 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6A4C741C88C07D5F

FASTA34137,773
        10         20         30         40         50         60 
MMSMNSKQAF SMHPILHEPK YPHLHTSSEA IRRACLPAPQ IQGNIFAGFD ETLLRGAEAL 

        70         80         90        100        110        120 
AAVDIVSQKT HPFKPDATYH TMSSVSCTPT SSSVHLHHPS VLTTHHPHHH HHQPAQGLEG 

       130        140        150        160        170        180 
ELLDHLNSAL PLGGVPGPDV GSTPSHPHSH MSAINHMAHH SQPMNMSHPH GLASHAVISG 

       190        200        210        220        230        240 
PETETDPREL ESFAERFKQR RIKLGVTQAD VGSALANLKI PGVGCLSQST ICRFESLTLS 

       250        260        270        280        290        300 
HNNMVALKPI LEAWLEEAER AQREKMTKPE IYTGGDKKRK RTSIAAPEKR SLEAYFAVQP 

       310        320        330        340 
RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRMKFSAT Y 

« Hide

References

[1]"Identification of a chicken homologue in the Brn-3 subfamily of POU-transcription factors."
Lindeberg J.K., Klint P., Williams R., Ebendal T.
Brain Res. Dev. Brain Res. 100:169-182(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Spinal ganglion.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X91998 mRNA. Translation: CAA63049.1.
X91997 Genomic DNA. Translation: CAA63048.1.
RefSeqNP_990090.1. NM_204759.1.
UniGeneGga.282.

3D structure databases

ProteinModelPortalQ91998.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000045448; ENSGALP00000041494; ENSGALG00000026243.
GeneID395521.
KEGGgga:395521.

Organism-specific databases

CTD5459.

Phylogenomic databases

eggNOGNOG289030.
GeneTreeENSGT00750000117482.
HOGENOMHOG000116305.
HOVERGENHBG031829.
InParanoidQ91998.
KOK09366.
PhylomeDBQ91998.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815599.

Entry information

Entry nameBRN3_CHICK
AccessionPrimary (citable) accession number: Q91998
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families