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Q91998

- BRN3_CHICK

UniProt

Q91998 - BRN3_CHICK

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Protein

Brain-specific homeobox/POU domain protein 3

Gene

BRN3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in specifying terminally differentiated neuronal phenotypes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi277 – 33660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

GO - Biological processi

  1. cell migration in hindbrain Source: Ensembl
  2. central nervous system neuron differentiation Source: Ensembl
  3. habenula development Source: Ensembl
  4. innervation Source: Ensembl
  5. mesoderm development Source: Ensembl
  6. negative regulation of neuron apoptotic process Source: Ensembl
  7. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  8. neuron fate specification Source: Ensembl
  9. peripheral nervous system neuron development Source: Ensembl
  10. positive regulation of apoptotic process Source: Ensembl
  11. proprioception involved in equilibrioception Source: Ensembl
  12. regulation of neurogenesis Source: Ensembl
  13. sensory system development Source: Ensembl
  14. trigeminal nerve development Source: Ensembl
  15. ventricular compact myocardium morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific homeobox/POU domain protein 3
Short name:
Brain-3
Short name:
Brn-3
Gene namesi
Name:BRN3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. neuron projection Source: Ensembl
  2. nuclear chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Brain-specific homeobox/POU domain protein 3PRO_0000100744Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ91998.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 25978POU-specificPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi55 – 6511POU-IV boxAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG289030.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116305.
HOVERGENiHBG031829.
InParanoidiQ91998.
KOiK09366.
PhylomeDBiQ91998.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91998-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMSMNSKQAF SMHPILHEPK YPHLHTSSEA IRRACLPAPQ IQGNIFAGFD
60 70 80 90 100
ETLLRGAEAL AAVDIVSQKT HPFKPDATYH TMSSVSCTPT SSSVHLHHPS
110 120 130 140 150
VLTTHHPHHH HHQPAQGLEG ELLDHLNSAL PLGGVPGPDV GSTPSHPHSH
160 170 180 190 200
MSAINHMAHH SQPMNMSHPH GLASHAVISG PETETDPREL ESFAERFKQR
210 220 230 240 250
RIKLGVTQAD VGSALANLKI PGVGCLSQST ICRFESLTLS HNNMVALKPI
260 270 280 290 300
LEAWLEEAER AQREKMTKPE IYTGGDKKRK RTSIAAPEKR SLEAYFAVQP
310 320 330 340
RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRMKFSAT Y
Length:341
Mass (Da):37,773
Last modified:November 1, 1996 - v1
Checksum:i6A4C741C88C07D5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91998 mRNA. Translation: CAA63049.1.
X91997 Genomic DNA. Translation: CAA63048.1.
RefSeqiNP_990090.1. NM_204759.1.
UniGeneiGga.282.

Genome annotation databases

EnsembliENSGALT00000045448; ENSGALP00000041494; ENSGALG00000026243.
GeneIDi395521.
KEGGigga:395521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91998 mRNA. Translation: CAA63049.1 .
X91997 Genomic DNA. Translation: CAA63048.1 .
RefSeqi NP_990090.1. NM_204759.1.
UniGenei Gga.282.

3D structure databases

ProteinModelPortali Q91998.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000045448 ; ENSGALP00000041494 ; ENSGALG00000026243 .
GeneIDi 395521.
KEGGi gga:395521.

Organism-specific databases

CTDi 5459.

Phylogenomic databases

eggNOGi NOG289030.
GeneTreei ENSGT00760000118935.
HOGENOMi HOG000116305.
HOVERGENi HBG031829.
InParanoidi Q91998.
KOi K09366.
PhylomeDBi Q91998.

Miscellaneous databases

NextBioi 20815599.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a chicken homologue in the Brn-3 subfamily of POU-transcription factors."
    Lindeberg J.K., Klint P., Williams R., Ebendal T.
    Brain Res. Dev. Brain Res. 100:169-182(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Spinal ganglion.

Entry informationi

Entry nameiBRN3_CHICK
AccessioniPrimary (citable) accession number: Q91998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3