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Q91998

- BRN3_CHICK

UniProt

Q91998 - BRN3_CHICK

Protein

Brain-specific homeobox/POU domain protein 3

Gene

BRN3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May play a role in specifying terminally differentiated neuronal phenotypes.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi277 – 33660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain-specific homeobox/POU domain protein 3
    Short name:
    Brain-3
    Short name:
    Brn-3
    Gene namesi
    Name:BRN3
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 4

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341Brain-specific homeobox/POU domain protein 3PRO_0000100744Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ91998.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini182 – 25978POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi55 – 6511POU-IV boxAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG289030.
    GeneTreeiENSGT00750000117482.
    HOGENOMiHOG000116305.
    HOVERGENiHBG031829.
    InParanoidiQ91998.
    KOiK09366.
    PhylomeDBiQ91998.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91998-1 [UniParc]FASTAAdd to Basket

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    MMSMNSKQAF SMHPILHEPK YPHLHTSSEA IRRACLPAPQ IQGNIFAGFD    50
    ETLLRGAEAL AAVDIVSQKT HPFKPDATYH TMSSVSCTPT SSSVHLHHPS 100
    VLTTHHPHHH HHQPAQGLEG ELLDHLNSAL PLGGVPGPDV GSTPSHPHSH 150
    MSAINHMAHH SQPMNMSHPH GLASHAVISG PETETDPREL ESFAERFKQR 200
    RIKLGVTQAD VGSALANLKI PGVGCLSQST ICRFESLTLS HNNMVALKPI 250
    LEAWLEEAER AQREKMTKPE IYTGGDKKRK RTSIAAPEKR SLEAYFAVQP 300
    RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRMKFSAT Y 341
    Length:341
    Mass (Da):37,773
    Last modified:November 1, 1996 - v1
    Checksum:i6A4C741C88C07D5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91998 mRNA. Translation: CAA63049.1.
    X91997 Genomic DNA. Translation: CAA63048.1.
    RefSeqiNP_990090.1. NM_204759.1.
    UniGeneiGga.282.

    Genome annotation databases

    EnsembliENSGALT00000045448; ENSGALP00000041494; ENSGALG00000026243.
    GeneIDi395521.
    KEGGigga:395521.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91998 mRNA. Translation: CAA63049.1 .
    X91997 Genomic DNA. Translation: CAA63048.1 .
    RefSeqi NP_990090.1. NM_204759.1.
    UniGenei Gga.282.

    3D structure databases

    ProteinModelPortali Q91998.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000045448 ; ENSGALP00000041494 ; ENSGALG00000026243 .
    GeneIDi 395521.
    KEGGi gga:395521.

    Organism-specific databases

    CTDi 5459.

    Phylogenomic databases

    eggNOGi NOG289030.
    GeneTreei ENSGT00750000117482.
    HOGENOMi HOG000116305.
    HOVERGENi HBG031829.
    InParanoidi Q91998.
    KOi K09366.
    PhylomeDBi Q91998.

    Miscellaneous databases

    NextBioi 20815599.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a chicken homologue in the Brn-3 subfamily of POU-transcription factors."
      Lindeberg J.K., Klint P., Williams R., Ebendal T.
      Brain Res. Dev. Brain Res. 100:169-182(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Spinal ganglion.

    Entry informationi

    Entry nameiBRN3_CHICK
    AccessioniPrimary (citable) accession number: Q91998
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3