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Protein
Submitted name:

Antifreeze protein

Gene

AFP type II

Organism
Clupea harengus (Atlantic herring)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi109 – 1091CalciumCombined sources
Metal bindingi111 – 1111CalciumCombined sources
Metal bindingi116 – 1161CalciumCombined sources
Metal bindingi130 – 1301CalciumCombined sources
Metal bindingi131 – 1311CalciumCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Antifreeze proteinImported
Submitted name:
Antifreeze protein type IIImported
Gene namesi
Name:AFP type IIImported
Synonyms:antifreeze protein type IIImported
OrganismiClupea harengus (Atlantic herring)Imported
Taxonomic identifieri7950 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiClupeiClupeiformesClupeoideiClupeidaeClupea

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 147130Sequence analysisPRO_5007715393Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 32Combined sources
Disulfide bondi49 ↔ 142Combined sources
Disulfide bondi86 ↔ 117Combined sources
Disulfide bondi106 ↔ 128Combined sources
Disulfide bondi118 ↔ 134Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PY2X-ray1.70A/B/C/D/E/F18-147[»]
SMRiQ91992. Positions 21-147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 143116C-type lectinInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains C-type lectin domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG004151.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR002353. AntifreezeII.
IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
PRINTSiPR00356. ANTIFREEZEII.
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTVSLLVCA IVALTRAADE CPTDWKMFNG RCFLFNPLQL HWADAQESCM
60 70 80 90 100
KEGANLASIH SLEESTFVKE LTSADLIPSW IGGTDCQVST RWFWMDSTSM
110 120 130 140
DYADWCAAQP DTTLTECCIQ MNVGIGKCWN DTPCTHLHSS ICAKPLK
Length:147
Mass (Da):16,374
Last modified:November 1, 1996 - v1
Checksum:i0A20C4D0B0885A24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14722 mRNA. Translation: AAA49200.1.
S65819 mRNA. Translation: AAB28093.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14722 mRNA. Translation: AAA49200.1.
S65819 mRNA. Translation: AAB28093.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PY2X-ray1.70A/B/C/D/E/F18-147[»]
SMRiQ91992. Positions 21-147.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004151.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR002353. AntifreezeII.
IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
PRINTSiPR00356. ANTIFREEZEII.
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ91992_CLUHA
AccessioniPrimary (citable) accession number: Q91992
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.