Q91981 (OTX2_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein OTX2
Short name=zOTX2

Alternative name(s):
Orthodenticle homolog 2

Gene names

Name:

otx2

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain.
Subcellular location	Nucleus Probable.
Developmental stage	Appears at 9 hours of development, and at 12 hours of development significant levels are found in the developing brain posterior to ocular vesicles. Distributed mainly in the midbrain, part of the diencephalon beneath the epiphysis and in the epiphysis at 18 hours of development. Found in the ventral part of the midbrain and in the dorsal part of the diencephalon at 24 hours of development.
Sequence similarities	Belongs to the paired homeobox family. Bicoid subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW response to chemical stimulus Inferred from direct assay. Source: ZFIN
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Homeobox protein OTX2		PRO_0000049214
Regions
	DNA binding	38 – 97	60	Homeobox
	Compositional bias	95 – 101	7	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	Q91981 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 13D60DFC7A0FD16E	FASTA	289	31,594
	10 20 30 40 50 60 MMSYLKQPPY TVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL DVLEALFAKT 70 80 90 100 110 120 RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ QNGGQNKVRP AKKKSSPARE 130 140 150 160 170 180 ASSESGASGQ FTPPSSTSVP AISTTTAPVS IWSPASISPL SDPLSTSSSC MQRSYPMTYT 190 200 210 220 230 240 QASGYSQGYA GSTSYFGGMD CGSYLTPMHH QLTGPGSTLS PMSSNAVTSH LNQSPASLPT 250 260 270 280 QGYGASGLGF NSTADCLDYK DQASSWKLNF NADCLDYKDQ TSSWKFQVL

References

[1]	"Different spatio-temporal expressions of three otx homeoprotein transcripts during zebrafish embryogenesis." Mori H., Miyazaki Y., Morita T., Nitta H., Mishina M. Brain Res. Mol. Brain Res. 27:221-231(1994) [PubMed: 7898305] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: AB.
[2]	"Expression of two zebrafish orthodenticle-related genes in the embryonic brain." Li Y., Allende M.L., Finkelstein R., Weinberg E.S. Mech. Dev. 48:229-244(1994) [PubMed: 7893604] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D26173 mRNA. Translation: BAA05159.1. U14592 mRNA. Translation: AAA78901.1.
IPI	IPI00487412.
PIR	I51752.
RefSeq	NP_571326.1. NM_131251.1.
UniGene	Dr.334.
3D structure databases
ProteinModelPortal	Q91981.
SMR	Q91981. Positions 39-106.
ModBase	Search...
Protein-protein interaction databases
STRING	Q91981.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000008816; ENSDARP00000020202; ENSDARG00000011235. ENSDART00000126097; ENSDARP00000111153; ENSDARG00000011235.
GeneID	30501.
KEGG	dre:30501.
Organism-specific databases
CTD	5015.
ZFIN	ZDB-GENE-980526-406. otx2.
Phylogenomic databases
GeneTree	ENSGT00600000084183.
HOGENOM	HBG713848.
HOVERGEN	HBG004028.
InParanoid	Q91981.
OMA	ESRVQXE.
OrthoDB	EOG4C87T5.
PhylomeDB	Q91981.
Gene expression databases
ArrayExpress	Q91981.
Bgee	Q91981.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. IPR003022. Otx2_TF. IPR003025. Otx_TF. IPR013851. Otx_TF_C. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09326.
Pfam	PF00046. Homeobox. 1 hit. PF03529. TF_Otx. 1 hit. [Graphical view]
PRINTS	PR01257. OTX2HOMEOBOX. PR01255. OTXHOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTX2_DANRE

Accession

Primary (citable) accession number: Q91981

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program