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Protein

Homeobox protein OTX2

Gene

otx2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi38 – 9760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cellular response to alcohol Source: ZFIN
  • cerebellum development Source: ZFIN
  • hindbrain development Source: ZFIN
  • midbrain development Source: ZFIN
  • midbrain-hindbrain boundary development Source: ZFIN
  • retinal pigment epithelium development Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein OTX2
Short name:
zOTX2
Alternative name(s):
Orthodenticle homolog 2
Gene namesi
Name:otx2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 17

Organism-specific databases

ZFINiZDB-GENE-980526-406. otx2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Homeobox protein OTX2PRO_0000049214Add
BLAST

Proteomic databases

PaxDbiQ91981.

Expressioni

Developmental stagei

Appears at 9 hours of development, and at 12 hours of development significant levels are found in the developing brain posterior to ocular vesicles. Distributed mainly in the midbrain, part of the diencephalon beneath the epiphysis and in the epiphysis at 18 hours of development. Found in the ventral part of the midbrain and in the dorsal part of the diencephalon at 24 hours of development.

Gene expression databases

BgeeiQ91981.

Interactioni

Protein-protein interaction databases

BioGridi78681. 1 interaction.
STRINGi7955.ENSDARP00000111153.

Structurei

3D structure databases

ProteinModelPortaliQ91981.
SMRiQ91981. Positions 39-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 1017Poly-Gln

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2251. Eukaryota.
ENOG4111XIJ. LUCA.
GeneTreeiENSGT00820000126963.
HOGENOMiHOG000082677.
HOVERGENiHBG004028.
InParanoidiQ91981.
KOiK18490.
OMAiQNKVRPP.
OrthoDBiEOG74J98P.
PhylomeDBiQ91981.
TreeFamiTF351179.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003022. Otx2_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01257. OTX2HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91981-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSYLKQPPY TVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL
60 70 80 90 100
DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ
110 120 130 140 150
QNGGQNKVRP AKKKSSPARE ASSESGASGQ FTPPSSTSVP AISTTTAPVS
160 170 180 190 200
IWSPASISPL SDPLSTSSSC MQRSYPMTYT QASGYSQGYA GSTSYFGGMD
210 220 230 240 250
CGSYLTPMHH QLTGPGSTLS PMSSNAVTSH LNQSPASLPT QGYGASGLGF
260 270 280
NSTADCLDYK DQASSWKLNF NADCLDYKDQ TSSWKFQVL
Length:289
Mass (Da):31,594
Last modified:November 1, 1996 - v1
Checksum:i13D60DFC7A0FD16E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26173 mRNA. Translation: BAA05159.1.
U14592 mRNA. Translation: AAA78901.1.
PIRiI51752.
RefSeqiNP_571326.1. NM_131251.1.
XP_005158940.1. XM_005158883.2.
XP_009291522.1. XM_009293247.1.
UniGeneiDr.334.

Genome annotation databases

EnsembliENSDART00000008816; ENSDARP00000020202; ENSDARG00000011235.
ENSDART00000126097; ENSDARP00000111153; ENSDARG00000011235.
GeneIDi30501.
KEGGidre:30501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26173 mRNA. Translation: BAA05159.1.
U14592 mRNA. Translation: AAA78901.1.
PIRiI51752.
RefSeqiNP_571326.1. NM_131251.1.
XP_005158940.1. XM_005158883.2.
XP_009291522.1. XM_009293247.1.
UniGeneiDr.334.

3D structure databases

ProteinModelPortaliQ91981.
SMRiQ91981. Positions 39-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi78681. 1 interaction.
STRINGi7955.ENSDARP00000111153.

Proteomic databases

PaxDbiQ91981.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000008816; ENSDARP00000020202; ENSDARG00000011235.
ENSDART00000126097; ENSDARP00000111153; ENSDARG00000011235.
GeneIDi30501.
KEGGidre:30501.

Organism-specific databases

CTDi5015.
ZFINiZDB-GENE-980526-406. otx2.

Phylogenomic databases

eggNOGiKOG2251. Eukaryota.
ENOG4111XIJ. LUCA.
GeneTreeiENSGT00820000126963.
HOGENOMiHOG000082677.
HOVERGENiHBG004028.
InParanoidiQ91981.
KOiK18490.
OMAiQNKVRPP.
OrthoDBiEOG74J98P.
PhylomeDBiQ91981.
TreeFamiTF351179.

Miscellaneous databases

PROiQ91981.

Gene expression databases

BgeeiQ91981.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003022. Otx2_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01257. OTX2HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Different spatio-temporal expressions of three otx homeoprotein transcripts during zebrafish embryogenesis."
    Mori H., Miyazaki Y., Morita T., Nitta H., Mishina M.
    Brain Res. Mol. Brain Res. 27:221-231(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AB.
  2. "Expression of two zebrafish orthodenticle-related genes in the embryonic brain."
    Li Y., Allende M.L., Finkelstein R., Weinberg E.S.
    Mech. Dev. 48:229-244(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiOTX2_DANRE
AccessioniPrimary (citable) accession number: Q91981
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.