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Protein

Homeobox protein OTX2

Gene

otx2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 97HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • cellular response to alcohol Source: ZFIN
  • cerebellum development Source: ZFIN
  • hindbrain development Source: ZFIN
  • midbrain development Source: ZFIN
  • midbrain-hindbrain boundary development Source: ZFIN
  • retinal pigment epithelium development Source: ZFIN

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein OTX2
Short name:
zOTX2
Alternative name(s):
Orthodenticle homolog 2
Gene namesi
Name:otx2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 17

Organism-specific databases

ZFINiZDB-GENE-980526-406 otx2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492141 – 289Homeobox protein OTX2Add BLAST289

Proteomic databases

PaxDbiQ91981

Expressioni

Developmental stagei

Appears at 9 hours of development, and at 12 hours of development significant levels are found in the developing brain posterior to ocular vesicles. Distributed mainly in the midbrain, part of the diencephalon beneath the epiphysis and in the epiphysis at 18 hours of development. Found in the ventral part of the midbrain and in the dorsal part of the diencephalon at 24 hours of development.

Gene expression databases

BgeeiENSDARG00000011235
ExpressionAtlasiQ91981 baseline

Interactioni

Protein-protein interaction databases

BioGridi78681, 1 interactor
STRINGi7955.ENSDARP00000111153

Structurei

3D structure databases

ProteinModelPortaliQ91981
SMRiQ91981
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi95 – 101Poly-Gln7

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2251 Eukaryota
ENOG4111XIJ LUCA
GeneTreeiENSGT00900000140776
HOGENOMiHOG000082677
HOVERGENiHBG004028
InParanoidiQ91981
KOiK18490
OMAiSTADCLD
OrthoDBiEOG091G0K9K
PhylomeDBiQ91981
TreeFamiTF351179

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003022 Otx2_TF
IPR003025 Otx_TF
IPR013851 Otx_TF_C
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03529 TF_Otx, 1 hit
PRINTSiPR01257 OTX2HOMEOBOX
PR01255 OTXHOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q91981-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSYLKQPPY TVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL
60 70 80 90 100
DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ
110 120 130 140 150
QNGGQNKVRP AKKKSSPARE ASSESGASGQ FTPPSSTSVP AISTTTAPVS
160 170 180 190 200
IWSPASISPL SDPLSTSSSC MQRSYPMTYT QASGYSQGYA GSTSYFGGMD
210 220 230 240 250
CGSYLTPMHH QLTGPGSTLS PMSSNAVTSH LNQSPASLPT QGYGASGLGF
260 270 280
NSTADCLDYK DQASSWKLNF NADCLDYKDQ TSSWKFQVL
Length:289
Mass (Da):31,594
Last modified:November 1, 1996 - v1
Checksum:i13D60DFC7A0FD16E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26173 mRNA Translation: BAA05159.1
U14592 mRNA Translation: AAA78901.1
PIRiI51752
RefSeqiNP_571326.1, NM_131251.1
XP_005158940.1, XM_005158883.3
XP_009291522.1, XM_009293247.2
UniGeneiDr.334

Genome annotation databases

EnsembliENSDART00000008816; ENSDARP00000020202; ENSDARG00000011235
ENSDART00000126097; ENSDARP00000111153; ENSDARG00000011235
GeneIDi30501
KEGGidre:30501

Similar proteinsi

Entry informationi

Entry nameiOTX2_DANRE
AccessioniPrimary (citable) accession number: Q91981
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health