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Protein
Submitted name:

NMDA glutamate receptor subunit

Gene

grin1

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40Beta-D-mannoseCombined sources1
Binding sitei44Beta-D-mannoseCombined sources1
Binding sitei48MannoseCombined sources1
Metal bindingi67Zinc; via tele nitrogenCombined sources1
Metal bindingi94ZincCombined sources1
Metal bindingi100ZincCombined sources1
Binding sitei159Beta-D-mannoseCombined sources1
Binding sitei303MannoseCombined sources1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological processIon transport, Transport
LigandMetal-bindingCombined sources, ZincCombined sources

Protein family/group databases

TCDBi1.A.10.1.12. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

Names & Taxonomyi

Protein namesi
Submitted name:
NMDA glutamate receptor subunitImported
Gene namesi
Name:grin1Imported
Synonyms:NR1Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-866327. grin1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei581 – 599HelicalSequence analysisAdd BLAST19
Transmembranei654 – 676HelicalSequence analysisAdd BLAST23
Transmembranei832 – 856HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501084743421 – 904Sequence analysisAdd BLAST884

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi79 ↔ 329Combined sources
Glycosylationi224N-linked (GlcNAc...)Combined sources1
Glycosylationi297N-linked (GlcNAc...)Combined sources1
Glycosylationi321N-linked (GlcNAc...)Combined sources1
Glycosylationi389N-linked (GlcNAc...)Combined sources1

Interactioni

Protein-protein interaction databases

DIPiDIP-59169N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QEKX-ray2.00A/B23-405[»]
3QELX-ray2.60A/C23-405[»]
3QEMX-ray3.00A/C23-405[»]
5B3JX-ray2.90A/B23-405[»]
5EWJX-ray2.77A/C23-408[»]
5EWLX-ray2.98A/C23-408[»]
5EWMX-ray2.76A/C23-408[»]
5TPWX-ray2.91A24-408[»]
5TPZX-ray3.10A23-405[»]
5TQ0X-ray2.70A24-408[»]
5TQ2X-ray3.29A24-408[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini454 – 814PBPeInterPro annotationAdd BLAST361
Domaini460 – 526Lig_chan-Glu_bdInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG052638.
KOiK05208.

Family and domain databases

InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR018882. CaM-bd_C0_NMDA_rcpt_NR1.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF01094. ANF_receptor. 1 hit.
PF10562. CaM_bdg_C0. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
PRINTSiPR00177. NMDARECEPTOR.
SMARTiView protein in SMART
SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTMRLFLLA VLFLFSFARA GCDPKIVNIG AVLSTKKHEQ IFREAVNQAN
60 70 80 90 100
KRHFTRKIQL NATSVTHRPN AIQMALSVCE DLISSQVYAI LVSHPPAPTD
110 120 130 140 150
HLTPTPISYT AGFYRIPVIG LTTRMSIYSD KSIHLSFLRT VPPYSHQALV
160 170 180 190 200
WFEMMRLFNW NHVILIVSDD HEGRAAQKKL ETLLEGKESK SKKRNYENLD
210 220 230 240 250
QLSYDNKRGP KADKVLQFEP GTKNLTALLL EAKELEARVI ILSASEDDAT
260 270 280 290 300
AVYKSAAMLD MTGAGYVWLV GEREISGSAL RYAPDGIIGL QLINGKNESA
310 320 330 340 350
HISDAVAVVA QAIHELFEME NITDPPRGCV GNTNIWKTGP LFKRVLMSSK
360 370 380 390 400
YPDGVTGRIE FNEDGDRKFA NYSIMNLQNR KLVQVGIFNG SYIIQNDRKI
410 420 430 440 450
IWPGGETERP QGYQMSTRLK IVTIHQEPFV YVRPTTSDGT CREEYTINGD
460 470 480 490 500
PIKKVICNGP NETIPGRPTV PQCCYGFCVD LLIKLAREMN FTYEVHLVAD
510 520 530 540 550
GKFGTQERVN NSNKKEWNGM MGELLSGQAD MIVAPLTINN ERAQYIEFSK
560 570 580 590 600
PFKYQGLTIL VKKEIPRSTL DSFMQPFQST LWLLVGLSVH VVAVMLYLLD
610 620 630 640 650
RFSPFGRFKV NSEEEEEDAL TLSSAMWFSW GVLLNSGIGE GAPRSFSARI
660 670 680 690 700
LGMVWAGFAM IIVASYTANL AAFLVLDRPE ERITGINDPR LRNPSDKFIY
710 720 730 740 750
ATVKQSSVDI YFRRQVELST MYRHMEKHNY ESAAEAIQAV RDNKLHAFIW
760 770 780 790 800
DSAVLEFEAS QKCDLVTTGE LFFRSGFGIG MRKDSPWKQN VSLNILKSHE
810 820 830 840 850
NGFMEELDKT WVRYQECDSR SNAPATLTFE NMAGVFMLVA GGIVAGIFLI
860 870 880 890 900
FIEIAYKRHK DARRKQMQLA FAAVNVWRKN LQQYPPTDIT GQLNLSDPSV

STVV
Length:904
Mass (Da):101,894
Last modified:November 1, 1996 - v1
Checksum:i46D8FE0EA6D903F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94081 mRNA. Translation: CAA63825.1.
X94156 mRNA. Translation: CAA63871.1.
RefSeqiNP_001081615.1. NM_001088146.1.
UniGeneiXl.135.

Genome annotation databases

GeneIDi397953.
KEGGixla:397953.

Similar proteinsi

Entry informationi

Entry nameiQ91977_XENLA
AccessioniPrimary (citable) accession number: Q91977
Secondary accession number(s): Q91805
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources