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Protein

Glucagon-1

Gene

gcg1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.By similarity

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-1
Alternative name(s):
Glucagon I
Cleaved into the following 4 chains:
Gene namesi
Name:gcg1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Peptidei22 – 4928Glicentin-related polypeptide 1PRO_0000011357Add
BLAST
Peptidei52 – 8029Glucagon-1PRO_0000011358Add
BLAST
Propeptidei83 – 875By similarityPRO_0000011359
Peptidei90 – 12031Glucagon-like peptide 1-1By similarityPRO_0000011360Add
BLAST
Propeptidei123 – 13412PRO_0000011361Add
BLAST
Peptidei137 – 16933Glucagon-like peptide 2PRO_0000011362Add
BLAST
Propeptidei171 – 1788PRO_0000011363

Keywords - PTMi

Cleavage on pair of basic residues

Expressioni

Inductioni

Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.

Structurei

3D structure databases

ProteinModelPortaliQ91971.
SMRiQ91971. Positions 52-80, 90-119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG003010.

Family and domain databases

InterProiIPR015550. Glucagon.
IPR000532. Glucagon_GIP_secretin_VIP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PANTHERiPTHR11418:SF0. PTHR11418:SF0. 1 hit.
PfamiPF00123. Hormone_2. 3 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 3 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Intestinal (identifier: Q91971-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGIHSLAGV LLLVIVQRQL ASPLQEAEDN SSLETTDPLL EDLMGVSNVK
60 70 80 90 100
RHSEGTFSND YSKYQEERMA QDFVQWLMNS KRSGAPSKRH ADGTYTSDVS
110 120 130 140 150
TYLQDQAAKD FVSWLKSGRA RRESAEESRN GPMSRRHVDG SFTSDVNKVL
160 170
DSLAAKEYLL WVMTSKTSGK SNKRQEDH
Length:178
Mass (Da):20,034
Last modified:November 1, 1996 - v1
Checksum:i5CF6980CF2A9D58E
GO
Isoform Pancreatic (identifier: Q91971-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-178: Missing.

Show »
Length:123
Mass (Da):13,870
Checksum:i66CD670F06C24F1A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei124 – 17855Missing in isoform Pancreatic. CuratedVSP_050470Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19913 mRNA. Translation: AAC59667.1.
U19917 mRNA. Translation: AAC59669.1.
U19918 Genomic DNA. Translation: AAC60212.1.
U19919, U19918 Genomic DNA. Translation: AAC60213.1.
S78475 mRNA. Translation: AAB34505.1.
S78473 mRNA. Translation: AAB34504.2.
PIRiI51058.
RefSeqiNP_001118170.1. NM_001124698.1. [Q91971-1]
UniGeneiOmy.33144.

Genome annotation databases

GeneIDi100136745.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19913 mRNA. Translation: AAC59667.1.
U19917 mRNA. Translation: AAC59669.1.
U19918 Genomic DNA. Translation: AAC60212.1.
U19919, U19918 Genomic DNA. Translation: AAC60213.1.
S78475 mRNA. Translation: AAB34505.1.
S78473 mRNA. Translation: AAB34504.2.
PIRiI51058.
RefSeqiNP_001118170.1. NM_001124698.1. [Q91971-1]
UniGeneiOmy.33144.

3D structure databases

ProteinModelPortaliQ91971.
SMRiQ91971. Positions 52-80, 90-119.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100136745.

Organism-specific databases

CTDi100136745.

Phylogenomic databases

HOVERGENiHBG003010.

Family and domain databases

InterProiIPR015550. Glucagon.
IPR000532. Glucagon_GIP_secretin_VIP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PANTHERiPTHR11418:SF0. PTHR11418:SF0. 1 hit.
PfamiPF00123. Hormone_2. 3 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 3 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Trout and chicken proglucagon: alternative splicing generates mRNA transcripts encoding glucagon-like peptide 2."
    Irwin D.M., Wong J.
    Mol. Endocrinol. 9:267-277(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING.
    Tissue: Distal small intestine and Pancreas.

Entry informationi

Entry nameiGLUC1_ONCMY
AccessioniPrimary (citable) accession number: Q91971
Secondary accession number(s): Q91188, Q91408, Q92169
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.