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Protein

Receptor-type tyrosine-protein phosphatase

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei416 – 4161SubstrateUniRule annotation
Active sitei448 – 4481Phosphocysteine intermediateUniRule annotation
Binding sitei492 – 4921SubstrateUniRule annotation
Active sitei737 – 7371Phosphocysteine intermediateUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei158 – 18124HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 807788Receptor-type tyrosine-protein phosphataseSequence analysisPRO_5005942145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei803 – 8031PhosphotyrosineUniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025727.

Structurei

3D structure databases

SMRiQ91969. Positions 223-798.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini247 – 507261Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini427 – 49872TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST
Domaini539 – 796258Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini712 – 78776TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni448 – 4547Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000231464.
HOVERGENiHBG053758.
KOiK18032.
PhylomeDBiQ91969.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLWFFVLLL GSGLISVGAT NVTTEPPTTV PTSTRIPTKA PTAAPDGGTT
60 70 80 90 100
PRVSSLNVSS PMTTSAPASE PPTTTATSIS PNATTASLNA STPGTSVPTS
110 120 130 140 150
APVAISLPPS ATPSALLTAL PSTEAEMTER NVSATVTTQE TSSASHNGNS
160 170 180 190 200
DRRDETPIIA VMVALSSLLV IVFIIIVLYM LRFKKYKQAG SHSNSFRLPN
210 220 230 240 250
GRTDDAEPQS MPLLARSPST NRKYPPLPVD KLEEEINRRI GDDNKLFREE
260 270 280 290 300
FNALPACPIQ ATCEAASKEE NKEKNRYVNI LPYDHSRVHL TPVEGVPDSH
310 320 330 340 350
YINTSFINSY QEKNKFIAAQ GPKEETVNDF WRMIWEQNTA TIVMVTNLKE
360 370 380 390 400
RKECKCAQYW PDQGCWTYGN IRVSVEDVTV LVDYTVRKFC IQQVGDVTNK
410 420 430 440 450
KPQRLVTQFH FTSWPDFGVP FTPIGMLKFL KKVKTCNPQY AGAIVVHCSA
460 470 480 490 500
GVGRTGTFIV IDAMLDMMHA ERKVDVYGFV SRIRAQRCQM VQTDMQYVFI
510 520 530 540 550
YQALLEHYLY GDTELEVTSL EIHLQKIYNK VPGTSSNGLE EEFKKLTSIK
560 570 580 590 600
IQNDKMRTGN LPANMKKNRV LQIIPYEFNR VIIPVKRGEE NTDYVNASFI
610 620 630 640 650
DGYRRRTPTC QPRPVQHTIE DFWRMIWEWK SCSIVMLTEL EERGQEKCAQ
660 670 680 690 700
YWPSDGSVSY GDINVELKKE EECESYTVRD LLVTNTRENK SRQIRQFHFH
710 720 730 740 750
GWPEVGIPSD GKGMINIIAA VQKQQQQSGN HPMHCHCSAG AGRTGTFCAL
760 770 780 790 800
STVLERVKAE GILDVFQTVK SLRLQRPHMV QTLEQYEFCY KVVQEYIDAF

SDYANFK
Length:807
Mass (Da):90,736
Last modified:November 1, 1996 - v1
Checksum:iD43DF7C2B8F31B22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22437 mRNA. Translation: AAB04150.1.
Z32749 mRNA. Translation: CAA83657.1.
RefSeqiNP_990485.1. NM_205154.2.
UniGeneiGga.3505.

Genome annotation databases

GeneIDi396060.
KEGGigga:396060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22437 mRNA. Translation: AAB04150.1.
Z32749 mRNA. Translation: CAA83657.1.
RefSeqiNP_990485.1. NM_205154.2.
UniGeneiGga.3505.

3D structure databases

SMRiQ91969. Positions 223-798.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396060.
KEGGigga:396060.

Organism-specific databases

CTDi5786.

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000231464.
HOVERGENiHBG053758.
KOiK18032.
PhylomeDBiQ91969.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Fang K.S.
    Thesis (1993), Unknown Institution
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  2. Fang K.S.
    Thesis (1993), Cardiovascular Research Institute, University of California, San Francisco
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  3. "Characterization of chicken protein tyrosine phosphatase alpha and its expression in the central nervous system."
    Fang K.S., Martins-Green M., Williams L.T., Hanafusa H.
    Brain Res. Mol. Brain Res. 37:1-14(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ91969_CHICK
AccessioniPrimary (citable) accession number: Q91969
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.