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Protein
Submitted name:

APP747

Gene

APP747

Organism
Xenopus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiI02.015.

Names & Taxonomyi

Protein namesi
Submitted name:
APP747Imported
Gene namesi
Name:APP747Imported
OrganismiXenopusImported
Taxonomic identifieri8353 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinae

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei678 – 700HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ91963.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini287 – 337BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili402 – 436Sequence analysisAdd BLAST35

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG000051.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
4.10.410.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 2 hits.
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
PR00204. BETAAMYLOID.
SMARTiSM00006. A4_EXTRA. 1 hit.
SM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91963-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPYKLARAD CRRLALEVLV DGNGGLLAEP QIAMFSVARL NMHMNVQNGK
60 70 80 90 100
WETDVSGCIG TKEGILQYCQ EVYPELQITN VVEANQPVTI QNWCKKGRKQ
110 120 130 140 150
CKSRTHIVVP YRCLVGEFVS DALLVPDKCK FLHQERMDIC ETHLHWHTVA
160 170 180 190 200
KESCSEKSMS LHEYGMLLPC GIDKFRGVEF VCCPSAEESE SFDSADAAED
210 220 230 240 250
DCDVWWGGAD ADYVDRSDDK AVEAQPDEEE EVVEVEEEET DDDEDDGDEA
260 270 280 290 300
EEEPEEPYEE ATERTTSIAT TTTTTTESVE EVVREVCSEQ AETGPCRAMI
310 320 330 340 350
SRWYYDVTES KCAQFIYGGC GGNRNNFESD DYCMAVCGSV IPATAASTPD
360 370 380 390 400
AVDKYLENPN DENEHDRFLK AKERLEGKHR EKMSEVMKEW EEAERQAKNL
410 420 430 440 450
PKADKKAVIQ HFQEKVESLE QEAAKQRQQL VETHMARVEA MLNDRRRIAL
460 470 480 490 500
ENYITALQAD PPRPRHVFNM LKKYVRAEQK DRQHTLKHFE HVRMVDPKKA
510 520 530 540 550
AQIRSQVMTH LRVINERMNQ SFSLLYKVPA VAEEIQDEVD ELFQKEQNYS
560 570 580 590 600
DDMVSNMVSD HRVSYGNDAL MPSLSETKTT VELLPVDGEF NIEDLQPWHS
610 620 630 640 650
FGVDSVPANT ENEVEPVDAR PAADRGLTTR PGSGLTNIKT EEISEVKMDS
660 670 680 690 700
EYRHDTAYEV HHQKLVFFAE EVGSNKGAII GLMVGGVVIA TVIVITLVML
710 720 730 740
KKKQYTTIHH GVVEVDAAVT PEERHLTKMQ QNGYENPTYK FFEQMQN
Length:747
Mass (Da):84,893
Last modified:November 1, 1996 - v1
Checksum:iA75E81885681D948
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S52417 mRNA. Translation: AAB24853.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S52417 mRNA. Translation: AAB24853.1.

3D structure databases

ProteinModelPortaliQ91963.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI02.015.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000051.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
4.10.410.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 2 hits.
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
PR00204. BETAAMYLOID.
SMARTiSM00006. A4_EXTRA. 1 hit.
SM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ91963_9PIPI
AccessioniPrimary (citable) accession number: Q91963
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.