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Protein

Serine/threonine-protein kinase receptor

Gene

activin receptor: XAR1

Organism
Xenopus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorUniRule annotationSAAS annotationImported, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase receptorUniRule annotation (EC:2.7.11.30UniRule annotation)
Gene namesi
Name:activin receptor: XAR1Imported
OrganismiXenopusImported
Taxonomic identifieri8353 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinae

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei136 – 158HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500431843222 – 510Serine/threonine-protein kinase receptorSequence analysisAdd BLAST489

Structurei

3D structure databases

ProteinModelPortaliQ91962.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 476Protein kinaseInterPro annotationAdd BLAST289

Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.UniRule annotationSAAS annotation
Contains 1 protein kinase domain.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG054502.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAVPLTLA LLLATFRAGS GHDEVETREC IYYNANWELE KTNQSGVESC
60 70 80 90 100
EGEKDKRLHC YASWRNNSGF IELVKKGCWL DDFNCYDRQE CIAKEENPQV
110 120 130 140 150
FFCCCEGNYC NKKFTHLPEV ETFDPKPQPM PSVLNILIYS LLPIAGLSMV
160 170 180 190 200
ILLAFWMYRH RKPPYGHVDL NEDPGPTPPS PMVGLKPLQL LEIKARGRFG
210 220 230 240 250
CVWKARLLNE YVAVKISPVQ DKQSWQCEKE IFNTPGMKHE NLLEFIAAEK
260 270 280 290 300
RGSNLEMELW LITAFHDKGS LTDYLKGNLV NWNELCHITE TMARGLSYLH
310 320 330 340 350
EDVPRCKGEG HKPAIAHRDF KSKNVLIRND LTAILADFGL AVRFEPGKPP
360 370 380 390 400
GDTHGQVGTR RYMAPEVLEG AINFQRDSFL RIDMYAMGLV LWEIVSRCTA
410 420 430 440 450
ADGPVDEYLL PFEEEIGQHP SLEDLQEVVV HKKMRPVFKD HWLKHPGLAQ
460 470 480 490 500
LCVTIEECWD HDAEARLSAG CVEERISQTR KSVNGTTSDC LVSIVTSVTN
510
VDLPPKESSI
Length:510
Mass (Da):57,780
Last modified:November 1, 1996 - v1
Checksum:iC6C07B6A432236A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S49438 mRNA. Translation: AAB24192.1.
PIRiA56926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S49438 mRNA. Translation: AAB24192.1.
PIRiA56926.

3D structure databases

ProteinModelPortaliQ91962.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG054502.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ91962_9PIPI
AccessioniPrimary (citable) accession number: Q91962
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.