Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein vent1

Gene

vent1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Cooperates with vent2 in a ventral signaling pathway downstream of bmp4, which antagonizes the Spemann organizer and dorsal mesoderm formation, and leads to ventral mesoderm formation. Acts downstream of bmp4 to repress transcription of foxa4-B/XFD-1'. Binds to DNA with preference for the target sequence 5'-CTATT[T/C]G-3'. Also binds 5'-TGCATTTTG-3' at a lower frequency, and occasionally 5'-TTGATC-3'. Binds to the homeobox 2 (HBX2) repressor element in the promoter of the myf5 gene and represses myf5 transcription in the ventral domain.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi129 – 188HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • BMP signaling pathway Source: UniProtKB
  • determination of ventral identity Source: UniProtKB
  • mesoderm formation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein vent1
Short name:
Xvent-1
Gene namesi
Name:vent1
Synonyms:vent-11 Publication
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-920881 ventx1.2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002797221 – 264Homeobox protein vent1Add BLAST264

Expressioni

Tissue specificityi

Expressed in the ventral marginal zone of gastrulae. At stage 11.5, also expressed in the ventral region of the animal cap (ectoderm). At the end of gastrulation, predominantly localized to the ventral and lateral regions of the closing slit blastopore. At early tail bud stage, expression is maintained only in the forming proctodeum.1 Publication

Developmental stagei

Expression begins in the late blastula, peaks at state 11 (early gastrula) and decreases thereafter.1 Publication

Inductioni

By bmp4. Suppressed by gsc, acting in a negative cross-regulatory loop.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ91926
SMRiQ91926
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal region is required for repressor function.1 Publication

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG082072

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q91926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQGFSIDL ILARSKEEAT DGKDSMSSRP HIPCAPQPLP PTKYAKEMPR
60 70 80 90 100
KKDGQDVQEH TTSFQCSLGE QVINRPSANP SLAAMHRSSG SSDEFSPPGS
110 120 130 140 150
EDDSTESSGR SSQENDTEQR EKSPKSDLQR RLRTAFTPQQ ISKLEQAFNK
160 170 180 190 200
QRYLGAPERK KLATSLQLSE IQVKTWFQNR RMKLKRQIQD KQHSLVPPPV
210 220 230 240 250
CYPQTFPYYP GGFPVPLNSG SFYQPRALPF QAPQHSYIPQ PLHHHVRMSS
260
HQEQYPPLFG AQYM
Length:264
Mass (Da):29,978
Last modified:November 1, 1996 - v1
Checksum:i356853895AC555B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92851 mRNA Translation: CAA63437.1
PIRiS66151
RefSeqiNP_001091390.1, NM_001097921.1
UniGeneiXl.51158

Genome annotation databases

GeneIDi100037246
KEGGixla:100037246

Similar proteinsi

Entry informationi

Entry nameiVENT1_XENLA
AccessioniPrimary (citable) accession number: Q91926
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health