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Protein

Homeobox protein vent1

Gene

vent1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Cooperates with vent2 in a ventral signaling pathway downstream of bmp4, which antagonizes the Spemann organizer and dorsal mesoderm formation, and leads to ventral mesoderm formation. Acts downstream of bmp4 to repress transcription of foxa4-B/XFD-1'. Binds to DNA with preference for the target sequence 5'-CTATT[T/C]G-3'. Also binds 5'-TGCATTTTG-3' at a lower frequency, and occasionally 5'-TTGATC-3'. Binds to the homeobox 2 (HBX2) repressor element in the promoter of the myf5 gene and represses myf5 transcription in the ventral domain.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi129 – 188HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • BMP signaling pathway Source: UniProtKB
  • determination of ventral identity Source: UniProtKB
  • mesoderm formation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein vent1
Short name:
Xvent-1
Gene namesi
Name:vent1
Synonyms:vent-11 Publication
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-920881. ventx1.2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002797221 – 264Homeobox protein vent1Add BLAST264

Expressioni

Tissue specificityi

Expressed in the ventral marginal zone of gastrulae. At stage 11.5, also expressed in the ventral region of the animal cap (ectoderm). At the end of gastrulation, predominantly localized to the ventral and lateral regions of the closing slit blastopore. At early tail bud stage, expression is maintained only in the forming proctodeum.1 Publication

Developmental stagei

Expression begins in the late blastula, peaks at state 11 (early gastrula) and decreases thereafter.1 Publication

Inductioni

By bmp4. Suppressed by gsc, acting in a negative cross-regulatory loop.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ91926.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal region is required for repressor function.1 Publication

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG082072.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQGFSIDL ILARSKEEAT DGKDSMSSRP HIPCAPQPLP PTKYAKEMPR
60 70 80 90 100
KKDGQDVQEH TTSFQCSLGE QVINRPSANP SLAAMHRSSG SSDEFSPPGS
110 120 130 140 150
EDDSTESSGR SSQENDTEQR EKSPKSDLQR RLRTAFTPQQ ISKLEQAFNK
160 170 180 190 200
QRYLGAPERK KLATSLQLSE IQVKTWFQNR RMKLKRQIQD KQHSLVPPPV
210 220 230 240 250
CYPQTFPYYP GGFPVPLNSG SFYQPRALPF QAPQHSYIPQ PLHHHVRMSS
260
HQEQYPPLFG AQYM
Length:264
Mass (Da):29,978
Last modified:November 1, 1996 - v1
Checksum:i356853895AC555B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92851 mRNA. Translation: CAA63437.1.
PIRiS66151.
RefSeqiNP_001091390.1. NM_001097921.1.
UniGeneiXl.51158.

Genome annotation databases

GeneIDi100037246.
KEGGixla:100037246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92851 mRNA. Translation: CAA63437.1.
PIRiS66151.
RefSeqiNP_001091390.1. NM_001097921.1.
UniGeneiXl.51158.

3D structure databases

ProteinModelPortaliQ91926.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100037246.
KEGGixla:100037246.

Organism-specific databases

CTDi100037246.
XenbaseiXB-GENE-920881. ventx1.2.

Phylogenomic databases

HOVERGENiHBG082072.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVENT1_XENLA
AccessioniPrimary (citable) accession number: Q91926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.