Zinc finger protein SNAI2 - Xenopus laevis (African clawed frog)

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Q91924 (SNAI2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 92. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Zinc finger protein SNAI2

Alternative name(s):
Protein slug-alpha
Protein snail homolog 2
Snail protein homolog Slug
Short name=xSlu

Gene names

Name:	snai2
Synonyms:	slu, slug

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable transcriptional repressor. Acts downstream of snai1 in the specification of the neural crest and neural crest migration. Ref.4 Ref.5
Subunit structure	Interacts (via SNAG domain) with limd1 (via LIM domains), wtip (via LIM domains) and ajuba (via LIM domains). Ref.5
Subcellular location	Nucleus Probable.
Tissue specificity	First expressed on the lateral side of stage 12 embryos. At stage 14, strongly expressed in the lateral neural folds. At stage 16, expressed in pre-migratory neural crest cells. At stage 18, expression is dispersed over the neural plate in a pattern surrounding the rhombomeres. At stage 22, expressed in neural crest derivatives, including the branchial arches and the tissues surrounding the eyes and forebrain. After stage 17, expression is weak in the lateral plate mesoderm, increasing at stage 26, but was down-regulated in the pronephros region at stage 26. Ref.1 Ref.2 Ref.4
Induction	By a combination of noggin and fgf2/bfgf in ectoderm. By wnt signaling. Ref.1 Ref.2
Sequence similarities	Belongs to the snail C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein Repressor
Gene Ontology (GO)
Biological_process	neural crest cell fate specification Inferred from genetic interaction Ref.4. Source: UniProtKB neural crest cell migration Inferred from direct assay Ref.4. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 266

266

Zinc finger protein SNAI2

PRO_0000047035

Regions

Zinc finger

126 – 148

C2H2-type 1

Zinc finger

157 – 179

C2H2-type 2

Zinc finger

183 – 205

C2H2-type 3

Zinc finger

211 – 233

C2H2-type 4

Zinc finger

239 – 262

C2H2-type 5; atypical

Region

1 – 20

SNAG domain By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q91924 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 3316D38EF220B769
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FASTA

266

29,895

        10         20         30         40         50         60 
MPRSFLVKKH FNSAKKPNYG ELDNHTVIIS PFLYERYPVS VLPQPDIYSS VAYSPITVWT 

        70         80         90        100        110        120 
GLLHPPLPSD LSPLSGYPSS LGRVSPPPQS DTSSKDHSGS ESPISDEEER LQTKLSDSHA 

       130        140        150        160        170        180 
IEAEKFQCSL CSKTYSTFSG LAKHKQLHCD AQSRKSFSCK YCEKEYVSLG ALKMHIRTHT 

       190        200        210        220        230        240 
LPCVCKICGK AFSRPWLLQG HIRTHTGEKP FSCPHCNRAF ADRSNLRAHL QTHSDVKKYQ 

       250        260 
CKNCSKTFSR MSLLHKHEES GCCVAH

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Induction of the prospective neural crest of Xenopus." Mayor R.M., Morgan R.M., Sargent M.G. Development 121:767-777(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION. Tissue: Neurula.
[2]	"Cloning and characterization of three Xenopus slug promoters reveal direct regulation by Lef/beta-catenin signaling." Vallin J., Thuret R., Giacomello E., Faraldo M.M., Thiery J.P., Broders F. J. Biol. Chem. 276:30350-30358(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, INDUCTION. Tissue: Neurula.
[3]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tadpole.
[4]	"Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest." Aybar M.J., Nieto M.A., Mayor R. Development 130:483-494(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[5]	"Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus." Langer E.M., Feng Y., Zhaoyuan H., Rauscher F.J. III, Kroll K.L., Longmore G.D. Dev. Cell 14:424-436(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH LIMD1; AJUBA AND WTIP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X80269 mRNA. Translation: CAA56556.1. AF368040 Genomic DNA. Translation: AAK54137.1. AF368041 mRNA. Translation: AAK54138.1. BC054144 mRNA. Translation: AAH54144.1.
PIR	S52245.
RefSeq	NP_001079751.1. NM_001086282.1.
UniGene	Xl.3818.
3D structure databases
ProteinModelPortal	Q91924.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	379440.
KEGG	xla:379440.
Organism-specific databases
CTD	379440.
Xenbase	XB-GENE-6255814. snai2.
Phylogenomic databases
HOVERGEN	HBG007477.
KO	K05706.
Family and domain databases
Gene3D	3.30.160.60. 3 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SNAI2_XENLA

Accession

Primary (citable) accession number: Q91924
Secondary accession number(s): Q5D087

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents