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Protein
Submitted name:

Inositol 1,4,5-triphosphate receptor

Gene

itpr1

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Inositol 1,4,5-triphosphate receptorImported
Gene namesi
Name:itpr1Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-920773. itpr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2221 – 224323HelicalSequence analysisAdd
BLAST
Transmembranei2255 – 227319HelicalSequence analysisAdd
BLAST
Transmembranei2301 – 231919HelicalSequence analysisAdd
BLAST
Transmembranei2339 – 236628HelicalSequence analysisAdd
BLAST
Transmembranei2387 – 240923HelicalSequence analysisAdd
BLAST
Transmembranei2514 – 253724HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ91908.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PKD2Q135632EBI-9633447,EBI-7813714From a different organism.

GO - Molecular functioni

  • ion channel binding Source: BHF-UCL

Protein-protein interaction databases

IntActiQ91908. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ91908.
SMRiQ91908. Positions 7-225, 236-587.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 16655MIRInterPro annotationAdd
BLAST
Domaini173 – 22351MIRInterPro annotationAdd
BLAST
Domaini231 – 28757MIRInterPro annotationAdd
BLAST
Domaini294 – 35865MIRInterPro annotationAdd
BLAST
Domaini364 – 42057MIRInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2631 – 267242Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG052158.
KOiK04958.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 4 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91908-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKMSSFLH VGDIVSLYAE GSVNGFINTL GLVDDRSVVQ PDAGDLNNPP
60 70 80 90 100
KKFRDCLFRL CPMNRYSAQK QFWKAAKPGA SSTTDTVLLN KLHHAADLEK
110 120 130 140 150
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT
160 170 180 190 200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSQQL
210 220 230 240 250
SDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF
260 270 280 290 300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
310 320 330 340 350
SLFRFKHLAT GHYLAAEIDA EPDAGNARMQ VVPEKMMCTL ISVPEGNDIS
360 370 380 390 400
SIFELDPTTL RGGDSLVPRN SYVRLRHLCT NTWVHSTNSP IDKDEEKPVM
410 420 430 440 450
LRIGTSPVKE DKEAFAIVPV SPAEVRDLDF ANDASKVLSS IAGKLEKGTI
460 470 480 490 500
TQNERRAVTK LLEELVYFVT GLVNSGHDIL EVLVNKPNRE RQKLMREQNI
510 520 530 540 550
LKQIFKLLQA PFTDSGDGPM LRLEELGDQR HAPFRHICRL CYRVLRHSQQ
560 570 580 590 600
DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI
610 620 630 640 650
DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPANADIL
660 670 680 690 700
IETKLVLSRF EFEGVASGES SLEAGEDEEE VWLFWKASNK EIRSRSVREL
710 720 730 740 750
AQDAKEGQKE DQDVLNYYRY QLNLFARMCL DRQYLAINEI SGQLDVDLIL
760 770 780 790 800
RCMSDENLPF DLRASFCRLM LHMHVDRDPQ EQVTPVKYAR LWSEIPSEIA
810 820 830 840 850
IDDYDSSGTS RDDIKERFAQ TMEFVEEYLR DVVGQRFPFA DKEKNKLTFE
860 870 880 890 900
VVNLARNLIY FGFYNFSDLL RLTKILLAIV DCVHLIANFP SGKLGKGEES
910 920 930 940 950
KGGSNVMRSI HGVGELMTQV VLRGGGFLPM TPMAAPEGTI KAQREPEKED
960 970 980 990 1000
ILVMDTKLKI IEILQFILNV RLDYRISCLL CIFKSEFDES NAQSVEGSTE
1010 1020 1030 1040 1050
AITVVPGTLD FEHIEEQAEG IFGGSEENTP LDLDDDGGRT FLRVLLHLTM
1060 1070 1080 1090 1100
HDYPPLVSGA LHLLFRHFSQ RQEVLQAFKQ VQLLVTSQDV DNYKQIKQDL
1110 1120 1130 1140 1150
DQLRSIVEKS ELWVYKGSGP EEVTAAQAGG ADKGETPGKA KKSESTSSYN
1160 1170 1180 1190 1200
YRVVKEILLR LSKLCVQENT TGRRNRKQQQ RLLRNMGAHS VVLELLQIPY
1210 1220 1230 1240 1250
EKTEDTRMQE IMKIAHEFLQ NFCAGNQQNQ ALLHKHINLF LTPGILEAVT
1260 1270 1280 1290 1300
MQHIFMNNFQ LCSEINERVV QHFAHCIETH GRNVQYIKFL QTIVKAEGRY
1310 1320 1330 1340 1350
IKKCQDIVMA ELVNSGEDVL VFYNDRASFQ TLVQMMRSER ERMDENSPLM
1360 1370 1380 1390 1400
YHIHLVELLA VCTEGKNVYT EIKCNSLLPL DDIVRVVTHE DCVPEVKIAY
1410 1420 1430 1440 1450
INFLNHCYVD TEVEMKEIYT SNHMWKLFEN FLVDICRVCN STSDRKHADI
1460 1470 1480 1490 1500
VLERYVTEIV MSIVNTFFSS PFSDQSTTLQ ASKLAVVHQT RQPVFVQLLQ
1510 1520 1530 1540 1550
AIFRVYHCNW LLPSQKASVE SCIRVLSDVA KSRTIAIPVD LDSQVNNLFL
1560 1570 1580 1590 1600
KSHNIVQKTA MSWRMSVRNA ARRDSVLTAS RDYRNIIERL QDIVSSLEDR
1610 1620 1630 1640 1650
LRPLVQAELS VLVDVLHRPE LLFPENTDAR KKCESGQFIC KLIRHTKLLL
1660 1670 1680 1690 1700
EENEEKLCIK VLQTLREMMA KDRGFGDKGE ALRVILVNRY YGNIRPAGRR
1710 1720 1730 1740 1750
ESLTSFGNGP LSGGSSGKSG GGSIGSGSLS RSEMSLSDVQ CHLDKQGASD
1760 1770 1780 1790 1800
LVIDLIMNAT SDRVFHESIL LAIALLEGGN TTIQHSFFCR LTEDKKSEKF
1810 1820 1830 1840 1850
FKVFFDRMKV AQQEIKATVT VNTSDLGSKK RDEEQSERET PHHQRVREPS
1860 1870 1880 1890 1900
GQITEEAKEQ LIEASVATKK AYYSFRREAD PDDHFSLGEG VMAVAEKGRD
1910 1920 1930 1940 1950
ELEMSAVITI MQPILRFLQL LCENHNRDLQ NFLRCQNNKS NYNLVCETLQ
1960 1970 1980 1990 2000
FLDCICGSTT GGLGLLGLYI NEKNVALINQ TLESLTEYCQ GPCHENQNCI
2010 2020 2030 2040 2050
ATHESNGIDI ITALILNDIN PLGRKRMDLV LELKNNASKL LLAIMESRHD
2060 2070 2080 2090 2100
SENAERILYN MRPKELVEVI KKAYLQGEVE FEDGESGEDY AASPRNVGHN
2110 2120 2130 2140 2150
IYILAHQLAR HNKELQHMLK PGVQTGEGDE ALEFYAKHTA QIEIVRLDRT
2160 2170 2180 2190 2200
MEQIVFPVPS ICEFLTKESK LRIYYTTERD EQGSKIHDFF QRSEDLFNEM
2210 2220 2230 2240 2250
NWQKKLRAQQ VLYWCSRNMT FWSSISFNLA VLMNLLVAFF YPFVNVHGGT
2260 2270 2280 2290 2300
LDSRLSGLLW TAMLVSLAIV IVLPKPHGIR ALIASTILRL IFSIGLQPTL
2310 2320 2330 2340 2350
FLLGAFNVCN KIIFLTSFVG NRGTFTRGYG AMVLDVEFLY HLLYLLICAM
2360 2370 2380 2390 2400
GVFVHEFFYS LLLFDLVYRE ETLLNVIKSV TRNGRSIILT AVLALILVYL
2410 2420 2430 2440 2450
FSIVGYLFFK DDFILEVDRL QNETIFPENG GTMTSELLYP EVCRVGSDTN
2460 2470 2480 2490 2500
CTHEELAQVT EEEEEEKEHT CETLLMCIVT VLSHGLRSGG GVGDVLRKPS
2510 2520 2530 2540 2550
KEEPLFAARV IYDLLFFFMV IIIVLNLIFG VIIDTFADLR SEKQKKEEVL
2560 2570 2580 2590 2600
KTTCFICGLE RDKFDNKTAT FEEHFKEEHN MWHYLFFIVL VKVKDSTEYT
2610 2620 2630 2640 2650
GPESYVAEMI KDRNLDWFPR MRAMSLVSSD SEGEQNELRN LQEKLESTMR
2660 2670 2680 2690
LVTNLSGQLS ELKDQMTEQR KQKQRIGLLG QPAHLNINPQ QPA
Length:2,693
Mass (Da):306,672
Last modified:November 1, 1996 - v1
Checksum:iCBF6AFFEF16A753C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14400 mRNA. Translation: BAA03304.1.
PIRiA40743.
RefSeqiNP_001084015.1. NM_001090546.1.
UniGeneiXl.101.

Genome annotation databases

GeneIDi399254.
KEGGixla:399254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14400 mRNA. Translation: BAA03304.1.
PIRiA40743.
RefSeqiNP_001084015.1. NM_001090546.1.
UniGeneiXl.101.

3D structure databases

ProteinModelPortaliQ91908.
SMRiQ91908. Positions 7-225, 236-587.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91908. 1 interaction.

Proteomic databases

PRIDEiQ91908.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399254.
KEGGixla:399254.

Organism-specific databases

CTDi3708.
XenbaseiXB-GENE-920773. itpr1.

Phylogenomic databases

HOVERGENiHBG052158.
KOiK04958.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 4 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Xenopus IP3 receptor: structure, function, and localization in oocytes and eggs."
    Kume S., Muto A., Aruga J., Nakagawa T., Michikawa T., Furuichi T., Nakade S., Okano H., Mikoshiba K.
    Cell 73:555-570(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: OvaryImported.

Entry informationi

Entry nameiQ91908_XENLA
AccessioniPrimary (citable) accession number: Q91908
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.