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Protein

Forkhead box protein I1-B

Gene

foxi1-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor. Essential for ventral specification of the early cephalic (head) ectoderm during gastrulation, playing a role in the 'non-neural' versus 'neural' cell fate choice. Binds to DNA via the target sequence 5'-[AG]TAAA[CT]A-3', with 5'-ATAAACA-3' being the preferred binding site.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi128 – 22295Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • determination of ventral identity Source: UniProtKB
  • ectoderm development Source: UniProtKB
  • nervous system development Source: UniProtKB-KW
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein I1-B
Short name:
FoxI1-B
Short name:
FoxI1b
Short name:
xFoxI1b
Alternative name(s):
Fork head domain-related protein 2'
Short name:
xFD-2'
Short name:
xFD2'
Gene namesi
Name:foxi1-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252155. foxi4.2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Forkhead box protein I1-BPRO_0000258002Add
BLAST

Expressioni

Tissue specificityi

Initially localized to the animal hemisphere (the presumptive ectoderm) of early-mid blastula embryos. Becomes restricted to head placodes, excluding the otic placodes, by the tailbud stages.2 Publications

Developmental stagei

Expression begins at the early-mid blastula stage. Levels are highest in the blastula and gastrula stages, after which levels decrease until the somite segregation stages. Expression persists to later developmental stages at a slightly higher extent than that of foxi1-A.2 Publications

Inductioni

Induced by Bmp-signaling. Suppressed by Wnt-signaling.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ91905.
SMRiQ91905. Positions 126-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG067944.
KOiK09401.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPVQQPAQH RSPASLLHLP HPKRAQEAPD MGLYCDNFMF SQQNLHPSQR
60 70 80 90 100
APNFSIGGEF TPPANPYLWL GGPGMNNAPN YSPAPAPYIP SAFSAPQRHF
110 120 130 140 150
MANSAAFGGA DLGWMSAASQ EELLKMVRPP YSYSALIAMA IQNASDKRLT
160 170 180 190 200
LSQIYQYVAE NFPFYKKSKA GWQNSIRHNL SLNDCFKKMP RDENDPGKGN
210 220 230 240 250
YWTLDSNCEK MFDNGNFRRK RKPKSESNNA KIAKRDEDHL NPKGKESPPM
260 270 280 290 300
ITPSSSPEVL SPTGHSKSPS PPTVTYTPCL TNFIGSMTAV DSATMNRQSP
310 320 330 340 350
LGLLNELSQR NITGLSSFIS GSAVDQSSEH QDNSLFYNRS PYYTNQKQPH
360
FLQQLHPQQP PLYQGRY
Length:367
Mass (Da):40,971
Last modified:November 1, 1996 - v1
Checksum:i3C893C5A4F8F6382
GO

Sequence cautioni

The sequence AAH78036 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31P → S in AAH78036 (Ref. 2) Curated
Sequence conflicti33 – 331L → F in AAH78036 (Ref. 2) Curated
Sequence conflicti47 – 471P → H in AAH78036 (Ref. 2) Curated
Sequence conflicti99 – 991H → Q in AAH78036 (Ref. 2) Curated
Sequence conflicti171 – 1711G → D no nucleotide entry (PubMed:1358174).Curated
Sequence conflicti214 – 2141N → RN no nucleotide entry (PubMed:1358174).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74316 mRNA. Translation: CAA52365.1.
BC078036 mRNA. Translation: AAH78036.1. Different initiation.
PIRiC56556.
S49009.
RefSeqiNP_001081619.1. NM_001088150.1.
UniGeneiXl.34912.

Genome annotation databases

GeneIDi397955.
KEGGixla:397955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74316 mRNA. Translation: CAA52365.1.
BC078036 mRNA. Translation: AAH78036.1. Different initiation.
PIRiC56556.
S49009.
RefSeqiNP_001081619.1. NM_001088150.1.
UniGeneiXl.34912.

3D structure databases

ProteinModelPortaliQ91905.
SMRiQ91905. Positions 126-217.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397955.
KEGGixla:397955.

Organism-specific databases

CTDi397955.
XenbaseiXB-GENE-6252155. foxi4.2.

Phylogenomic databases

HOVERGENiHBG067944.
KOiK09401.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXI1B_XENLA
AccessioniPrimary (citable) accession number: Q91905
Secondary accession number(s): Q6DCJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.