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Protein

Forkhead box protein I1-A

Gene

foxi1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor. Essential for ventral specification of the early cephalic (head) ectoderm during gastrulation, playing a role in the non-neural versus neural cell fate choice. Binds to DNA via the target sequence 5'-[AG]TAAA[CT]A-3', with 5'-ATAAACA-3' being the preferred binding site.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi127 – 221Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

  • DNA binding transcription factor activity Source: InterPro
  • sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • determination of ventral identity Source: UniProtKB
  • ectoderm development Source: UniProtKB
  • nervous system development Source: UniProtKB-KW
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein I1-A
Short name:
FoxI1-A
Short name:
FoxI1a
Short name:
xFoxI1a
Alternative name(s):
Fork head domain-related protein 2
Short name:
xFD-2
Short name:
xFD2
Gene namesi
Name:foxi1-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865722 foxi4.2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002580011 – 370Forkhead box protein I1-AAdd BLAST370

Proteomic databases

PRIDEiQ91904

Expressioni

Tissue specificityi

Initially localized to the animal hemisphere (the presumptive ectoderm) of early-mid blastula embryos. Becomes restricted to head placodes, excluding the otic placodes, by the tailbud stages.3 Publications

Developmental stagei

Expression begins at the early-mid blastula stage. Levels are highest during the blastula and gastrula stages, after which levels decreases until somite segregation. At later developmental stages, expressed at a slightly lower level than foxi1-B.3 Publications

Inductioni

Induced by Bmp-signaling. Suppressed by Wnt-signaling.2 Publications

Structurei

3D structure databases

ProteinModelPortaliQ91904
SMRiQ91904
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG067944
KOiK09401

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q91904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPVQQPAQH KCPASSLNPP HPKRAQEAPD MGLYCDNFMY QQHNLHPSHR
60 70 80 90 100
ATNFSIGDFT HQANPYLWLG GPGVNNSPSY SPTPAPYIPP AFSAPQRQFL
110 120 130 140 150
ANSAAFGGAD LGWMSAASQE ELLKRVRPPY SYSALIAMSI QNATDKRLTL
160 170 180 190 200
SQIYQYVAEN FPFYKKSKAG WQNSIRHNLS LNDCFKKMPR DENDPGKGNY
210 220 230 240 250
WTLDSNCEKM FDNGNFRRKR KPKSETNNIK IAKREEDHVS PKGKESPPMI
260 270 280 290 300
TPSSPKELSP TGHSKCPSPP TVTYTPCLTN FIGSMTAVDS ATMNRQGPLG
310 320 330 340 350
LLNELSQRNL NGLSSFISGS AVDQSPEHQD SSLFYNRSPY YSSLPTSNQK
360 370
QPPYLQQLHP QQSPLYQGRY
Length:370
Mass (Da):41,388
Last modified:November 1, 1996 - v1
Checksum:i6CC5A3F6B285E327
GO

Sequence cautioni

The sequence AAH80044 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167S → C in AAH80044 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74315 mRNA Translation: CAA52364.1
BC080044 mRNA Translation: AAH80044.1 Different initiation.
PIRiS49008
RefSeqiNP_001081617.1, NM_001088148.1
UniGeneiXl.5369

Genome annotation databases

GeneIDi397954
KEGGixla:397954

Similar proteinsi

Entry informationi

Entry nameiFXI1A_XENLA
AccessioniPrimary (citable) accession number: Q91904
Secondary accession number(s): Q68F03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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