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Protein

Forkhead box protein I1-A

Gene

foxi1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor. Essential for ventral specification of the early cephalic (head) ectoderm during gastrulation, playing a role in the non-neural versus neural cell fate choice. Binds to DNA via the target sequence 5'-[AG]TAAA[CT]A-3', with 5'-ATAAACA-3' being the preferred binding site.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi127 – 221Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • determination of ventral identity Source: UniProtKB
  • ectoderm development Source: UniProtKB
  • nervous system development Source: UniProtKB-KW
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein I1-A
Short name:
FoxI1-A
Short name:
FoxI1a
Short name:
xFoxI1a
Alternative name(s):
Fork head domain-related protein 2
Short name:
xFD-2
Short name:
xFD2
Gene namesi
Name:foxi1-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865722. foxi4.2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002580011 – 370Forkhead box protein I1-AAdd BLAST370

Expressioni

Tissue specificityi

Initially localized to the animal hemisphere (the presumptive ectoderm) of early-mid blastula embryos. Becomes restricted to head placodes, excluding the otic placodes, by the tailbud stages.3 Publications

Developmental stagei

Expression begins at the early-mid blastula stage. Levels are highest during the blastula and gastrula stages, after which levels decreases until somite segregation. At later developmental stages, expressed at a slightly lower level than foxi1-B.3 Publications

Inductioni

Induced by Bmp-signaling. Suppressed by Wnt-signaling.2 Publications

Structurei

3D structure databases

ProteinModelPortaliQ91904.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG067944.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPVQQPAQH KCPASSLNPP HPKRAQEAPD MGLYCDNFMY QQHNLHPSHR
60 70 80 90 100
ATNFSIGDFT HQANPYLWLG GPGVNNSPSY SPTPAPYIPP AFSAPQRQFL
110 120 130 140 150
ANSAAFGGAD LGWMSAASQE ELLKRVRPPY SYSALIAMSI QNATDKRLTL
160 170 180 190 200
SQIYQYVAEN FPFYKKSKAG WQNSIRHNLS LNDCFKKMPR DENDPGKGNY
210 220 230 240 250
WTLDSNCEKM FDNGNFRRKR KPKSETNNIK IAKREEDHVS PKGKESPPMI
260 270 280 290 300
TPSSPKELSP TGHSKCPSPP TVTYTPCLTN FIGSMTAVDS ATMNRQGPLG
310 320 330 340 350
LLNELSQRNL NGLSSFISGS AVDQSPEHQD SSLFYNRSPY YSSLPTSNQK
360 370
QPPYLQQLHP QQSPLYQGRY
Length:370
Mass (Da):41,388
Last modified:November 1, 1996 - v1
Checksum:i6CC5A3F6B285E327
GO

Sequence cautioni

The sequence AAH80044 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167S → C in AAH80044 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74315 mRNA. Translation: CAA52364.1.
BC080044 mRNA. Translation: AAH80044.1. Different initiation.
PIRiS49008.
RefSeqiNP_001081617.1. NM_001088148.1.
UniGeneiXl.5369.

Genome annotation databases

GeneIDi397954.
KEGGixla:397954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74315 mRNA. Translation: CAA52364.1.
BC080044 mRNA. Translation: AAH80044.1. Different initiation.
PIRiS49008.
RefSeqiNP_001081617.1. NM_001088148.1.
UniGeneiXl.5369.

3D structure databases

ProteinModelPortaliQ91904.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397954.
KEGGixla:397954.

Organism-specific databases

CTDi397954.
XenbaseiXB-GENE-865722. foxi4.2.

Phylogenomic databases

HOVERGENiHBG067944.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXI1A_XENLA
AccessioniPrimary (citable) accession number: Q91904
Secondary accession number(s): Q68F03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.