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Protein

ELAV-like protein 2

Gene

elavl2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Required for the vegetal localization of vg1 mRNA. Probably required for nervous system development.2 Publications

Caution

The 45 kDa RNA-binding proteins identified in PubMed:7969126 and PubMed:8873767, and PubMed:11087864 may correspond to elavl2/elrB.Curated

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: UniProtKB
  • uridine-rich cytoplasmic polyadenylylation element binding Source: UniProtKB

GO - Biological processi

  • intracellular mRNA localization Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • nervous system development Source: UniProtKB
  • protein homooligomerization Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, Ribonucleoprotein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 2
Alternative name(s):
Elav like-11 Publication
Short name:
Xel-1Imported
Protein ElrB1 Publication
p451 Publication
Gene namesi
Name:elavl2
Synonyms:el-1Imported, elavl2-aImported, elrBImported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-866091 elavl2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003913711 – 389ELAV-like protein 2Add BLAST389

Expressioni

Tissue specificityi

Expressed in brain, testis and ovary. Ovarian expression is restricted to follicle cells surrounding the oocyte. From the early tailbud stage, expression is neural-specific and is seen in both the central and peripheral nervous system in differentiating neurons but not proliferating precursors. Expressed in the retina from stage 32 with expression becoming restricted to the ganglion cell layer by later stages.4 Publications

Developmental stagei

Expressed both maternally and zygotically. Predominantly expressed in the early stages of oogenesis (stages I to III), with expression levels declining from stage IV onwards. Zygotic expression begins at the early tailbud stage.2 Publications

Interactioni

Subunit structurei

Part of a ribonucleoprotein (RNP) complex, at least composed of elavl1/elrA and/or elavl2/elrB, igf2bp3/vg1RBP, ddx6/Xp54, ybx2/frgy2, lsm14b/rap55b and, in a subset of RNP complexes, stau1/staufen. Binds RNA as a homooligomer.2 Publications

Protein-protein interaction databases

BioGridi98944, 1 interactor
IntActiQ91903, 1 interactor
MINTiQ91903

Structurei

3D structure databases

ProteinModelPortaliQ91903
SMRiQ91903
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 145RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini153 – 233RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini306 – 384RRM 3PROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the RRM elav family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG002295
KOiK13208

Family and domain databases

CDDicd12650 RRM1_Hu, 1 hit
cd12775 RRM2_HuB, 1 hit
cd12654 RRM3_HuB, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006548 ELAD_HU_SF
IPR034775 ELAV/Hu_RRM1
IPR034999 HuB_RRM2
IPR034914 HuB_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01661 ELAV_HUD_SF, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q91903-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVRLCDVAS LLRSGSWAAE PWTGQVIAAM ETQLSNGPTC NNTANCPNTI
60 70 80 90 100
NCSSPVESNN TEDSKTNLIV NYLPQNMTQE ELKSLFGSIG EIESCKLVRD
110 120 130 140 150
KITEGQSLGY GFVNYIDPKD AEKAINTLNG LRLQTKTIKV SYARPSSASI
160 170 180 190 200
RDANLYVSGL PKTMTQKELE QLFSQYGRII TSRILVDQVT GVSRGVGFIR
210 220 230 240 250
FDKRIEAEEA IKGLNGQKPP GATEPITVKF ANNPSQKVNH TILSQLYQSP
260 270 280 290 300
NRRYPGPLAQ QAQRFRLDNL LNMAYGGIKS RFSPMAIDGM TSLAGINFPG
310 320 330 340 350
HAGTGWCIFV YNLAPDADES ILWQMFGPFG AVTNVKVIRD FNTNKCKGFG
360 370 380
FVTMTNYDEA AMAIASLNGY RLGDRVLQVS FKTSKTHKA
Length:389
Mass (Da):42,709
Last modified:February 9, 2010 - v2
Checksum:i200C18CA6EE0D1BC
GO
Isoform 2 (identifier: Q91903-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-104: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:388
Mass (Da):42,580
Checksum:iDD22EEC8802105C0
GO

Sequence cautioni

The sequence AAH94189 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128L → V in CAA59430 (PubMed:7547471).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038717104Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85111 mRNA Translation: CAA59430.1
U17597 mRNA Translation: AAA96943.1
BC170539 mRNA Translation: AAI70539.1
BC094189 mRNA Translation: AAH94189.1 Different initiation.
PIRiI51676
RefSeqiNP_001081035.1, NM_001087566.1 [Q91903-1]
NP_001081613.1, NM_001088144.1
XP_018083833.1, XM_018228344.1 [Q91903-1]
XP_018083899.1, XM_018228410.1 [Q91903-1]
XP_018083945.1, XM_018228456.1 [Q91903-1]
XP_018083985.1, XM_018228496.1 [Q91903-1]
XP_018084043.1, XM_018228554.1 [Q91903-1]
XP_018084087.1, XM_018228598.1 [Q91903-1]
XP_018084130.1, XM_018228641.1 [Q91903-2]
XP_018084175.1, XM_018228686.1 [Q91903-2]
UniGeneiXl.1648
Xl.34955

Genome annotation databases

GeneIDi394342
KEGGixla:394342
xla:397952

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiELAV2_XENLA
AccessioniPrimary (citable) accession number: Q91903
Secondary accession number(s): B7ZSI9, Q52KU1, Q91583
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: March 28, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health