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Protein

ELAV-like protein 2

Gene

elavl2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Required for the vegetal localization of vg1 mRNA. Probably required for nervous system development.2 Publications

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: UniProtKB
  • nucleotide binding Source: InterPro
  • uridine-rich cytoplasmic polyadenylylation element binding Source: UniProtKB

GO - Biological processi

  • intracellular mRNA localization Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • nervous system development Source: UniProtKB
  • protein homooligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 2
Alternative name(s):
Elav like-11 Publication
Short name:
Xel-1Imported
Protein ElrB1 Publication
p451 Publication
Gene namesi
Name:elavl2
Synonyms:el-1Imported, elavl2-aImported, elrBImported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254447. elavl2.
XB-GENE-866091. elavl2.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389ELAV-like protein 2PRO_0000391371Add
BLAST

Expressioni

Tissue specificityi

Expressed in brain, testis and ovary. Ovarian expression is restricted to follicle cells surrounding the oocyte. From the early tailbud stage, expression is neural-specific and is seen in both the central and peripheral nervous system in differentiating neurons but not proliferating precursors. Expressed in the retina from stage 32 with expression becoming restricted to the ganglion cell layer by later stages.4 Publications

Developmental stagei

Expressed both maternally and zygotically. Predominantly expressed in the early stages of oogenesis (stages I to III), with expression levels declining from stage IV onwards. Zygotic expression begins at the early tailbud stage.2 Publications

Interactioni

Subunit structurei

Part of a ribonucleoprotein (RNP) complex, at least composed of elavl1/elrA and/or elavl2/elrB, igf2bp3/vg1RBP, ddx6/Xp54, ybx2/frgy2, lsm14b/rap55b and, in a subset of RNP complexes, stau1/staufen. Binds RNA as a homooligomer.2 Publications

Protein-protein interaction databases

BioGridi98944. 1 interaction.
IntActiQ91903. 1 interaction.
MINTiMINT-2880431.

Structurei

3D structure databases

ProteinModelPortaliQ91903.
SMRiQ91903. Positions 64-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 14580RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini153 – 23381RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini306 – 38479RRM 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RRM elav family.Sequence analysis
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG002295.
KOiK13208.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q91903-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVRLCDVAS LLRSGSWAAE PWTGQVIAAM ETQLSNGPTC NNTANCPNTI
60 70 80 90 100
NCSSPVESNN TEDSKTNLIV NYLPQNMTQE ELKSLFGSIG EIESCKLVRD
110 120 130 140 150
KITEGQSLGY GFVNYIDPKD AEKAINTLNG LRLQTKTIKV SYARPSSASI
160 170 180 190 200
RDANLYVSGL PKTMTQKELE QLFSQYGRII TSRILVDQVT GVSRGVGFIR
210 220 230 240 250
FDKRIEAEEA IKGLNGQKPP GATEPITVKF ANNPSQKVNH TILSQLYQSP
260 270 280 290 300
NRRYPGPLAQ QAQRFRLDNL LNMAYGGIKS RFSPMAIDGM TSLAGINFPG
310 320 330 340 350
HAGTGWCIFV YNLAPDADES ILWQMFGPFG AVTNVKVIRD FNTNKCKGFG
360 370 380
FVTMTNYDEA AMAIASLNGY RLGDRVLQVS FKTSKTHKA
Length:389
Mass (Da):42,709
Last modified:February 9, 2010 - v2
Checksum:i200C18CA6EE0D1BC
GO
Isoform 2 (identifier: Q91903-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-104: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:388
Mass (Da):42,580
Checksum:iDD22EEC8802105C0
GO

Sequence cautioni

The sequence AAH94189 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281L → V in CAA59430 (PubMed:7547471).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei104 – 1041Missing in isoform 2. 1 PublicationVSP_038717

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85111 mRNA. Translation: CAA59430.1.
U17597 mRNA. Translation: AAA96943.1.
BC170539 mRNA. Translation: AAI70539.1.
BC094189 mRNA. Translation: AAH94189.1. Different initiation.
PIRiI51676.
RefSeqiNP_001081035.1. NM_001087566.1. [Q91903-1]
NP_001081613.1. NM_001088144.1.
UniGeneiXl.1648.
Xl.34955.

Genome annotation databases

GeneIDi394342.
397952.
KEGGixla:394342.
xla:397952.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85111 mRNA. Translation: CAA59430.1.
U17597 mRNA. Translation: AAA96943.1.
BC170539 mRNA. Translation: AAI70539.1.
BC094189 mRNA. Translation: AAH94189.1. Different initiation.
PIRiI51676.
RefSeqiNP_001081035.1. NM_001087566.1. [Q91903-1]
NP_001081613.1. NM_001088144.1.
UniGeneiXl.1648.
Xl.34955.

3D structure databases

ProteinModelPortaliQ91903.
SMRiQ91903. Positions 64-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi98944. 1 interaction.
IntActiQ91903. 1 interaction.
MINTiMINT-2880431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi394342.
397952.
KEGGixla:394342.
xla:397952.

Organism-specific databases

CTDi394342.
397952.
XenbaseiXB-GENE-6254447. elavl2.
XB-GENE-866091. elavl2.

Phylogenomic databases

HOVERGENiHBG002295.
KOiK13208.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELAV2_XENLA
AccessioniPrimary (citable) accession number: Q91903
Secondary accession number(s): B7ZSI9, Q52KU1, Q91583
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: February 17, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

The 45 kDa RNA-binding proteins identified in PubMed:7969126 and PubMed:8873767, and PubMed:11087864 may correspond to elavl2/elrB.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.