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Q91896 (1433Z_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
14-3-3 protein zeta
Gene names
Name:ywhaz
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm.

Tissue specificity

Present in all adult tissues examined with the highest levels in the brain.

Sequence similarities

Belongs to the 14-3-3 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   PTMAcetylation
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 24524514-3-3 protein zeta
PRO_0000058633

Sites

Site561Interaction with phosphoserine on interacting protein By similarity
Site1271Interaction with phosphoserine on interacting protein By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict173 – 18513NFSVF…ILNCP → KLLCVLTNEESSTVQ Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q91896 [UniParc].

Last modified August 16, 2005. Version 2.
Checksum: 8ACF62C58E68C630

FASTA24527,729
        10         20         30         40         50         60 
MDKNELVQKA KLAEQAERYD DMAACMKRVT EEGGELSNEE RNLLSVAYKN VVGARRSSWR 

        70         80         90        100        110        120 
VVSSIEQKTE GAEKKQEMSR EYREKIEAEL REICNDVLNL LDKFLIANAT QPESKVFYLK 

       130        140        150        160        170        180 
MKGDYYRYLA EVAAGNAKTE IVGQSQKAYQ DAFDISKTEM QPTHPIRLGL ALNFSVFYYE 

       190        200        210        220        230        240 
ILNCPDKACA LAKAAFDEAI AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEQG 


EGGEN

« Hide

References

[1]"Sequence and expression analysis of a Xenopus laevis cDNA which encodes a homologue of mammalian 14-3-3 zeta protein."
Kousteni S., Tura F., Sweeney G.E., Ramji D.P.
Gene 190:279-285(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts."
Kumagai A., Yakowec P.S., Dunphy W.G.
Mol. Biol. Cell 9:345-354(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X95519 mRNA. Translation: CAA64773.1.
AF033312 mRNA. Translation: AAC41252.1.
UniGeneXl.21852.

3D structure databases

ProteinModelPortalQ91896.
SMRQ91896. Positions 1-232.
ModBaseSearch...

Proteomic databases

PRIDEQ91896.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

XenbaseXB-GENE-6256657. ywhaz.

Phylogenomic databases

HOVERGENHBG050423.

Family and domain databases

Gene3D1.20.190.20. 1 hit.
InterProIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERPTHR18860. PTHR18860. 1 hit.
PfamPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFPIRSF000868. 14-3-3. 1 hit.
PRINTSPR00305. 1433ZETA.
SMARTSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMSSF48445. 14-3-3. 1 hit.
PROSITEPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name1433Z_XENLA
AccessionPrimary (citable) accession number: Q91896
Secondary accession number(s): O57469
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 16, 2005
Last modified: April 3, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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