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Q91883

- GRP78_XENLA

UniProt

Q91883 - GRP78_XENLA

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Protein
78 kDa glucose-regulated protein
Gene
hspa5
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 414ATP By similarity
Nucleotide bindingi228 – 2303ATP By similarity
Nucleotide bindingi294 – 3018ATP By similarity
Nucleotide bindingi365 – 3684ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein
Short name:
GRP-78
Alternative name(s):
Heat shock 70 kDa protein 5
Immunoglobulin heavy chain-binding protein
Short name:
BiP
Gene namesi
Name:hspa5
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 65863978 kDa glucose-regulated protein
PRO_0000013571Add
BLAST

Proteomic databases

PRIDEiQ91883.

Structurei

3D structure databases

ProteinModelPortaliQ91883.
SMRiQ91883. Positions 30-571.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi655 – 6584Prevents secretion from ER By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG051845.
KOiK09490.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91883-1 [UniParc]FASTAAdd to Basket

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MVTMKLFALV LLVSASVFAS DDDDKKDDIG TVVGIDLGTT YSCVGVFKNG    50
RVEIIANDQG NRITPSYVAF TPEGERLIGD AAKNQLTSNP ENTVFDAKRL 100
IGRTWNDPSV QQDIKYLPFK VIEKKTKPYI EVDIGDQMKT FAPEEISAMV 150
LVKMKETAEA YLGRKVTHAV VTVPAYFNDA QRQATKDAGT IAGLNVMRII 200
NEPTAAAIAY GLDKKEGEKN ILVFDLGGGT FDVSLLTIDN GVFEVVATNG 250
DTHLGGEDFD QRVMEHFIKL YKKKTGKDVR ADKRAVQKLR REVEKAKRAL 300
SAQHQSRIEI ESFFEGEDFS ETLTRAKFEE LNMDLFRSTM KPVQKVLDDS 350
DLKKSDIDEI VLVGGSTRIP KIQQLVKELF NGKEPSRGIN PDEAVAYGAA 400
VQAGVLSGDQ DTGDLVLLDV CPLTLGIETV GGVMTKLIPR NTVVPTKKSQ 450
IFSTASDNQP TVTIKVYEGE RPLTKDNHLL GTFDLTGIPP APRGVPQIEV 500
TFEIDVNGIL RVTAEDKGTG NKNKITITND QNRLTPEEIE RMVTDAEKFA 550
EEDKKLKERI DTRNELESYA YSLKNQIGDK EKLGGKLSSE DKETIEKAVE 600
EKIEWLESHQ DADIEDFKAK KKELEEIVQP IVGKLYGGAG APPPEGAEGA 650
EETEKDEL 658
Length:658
Mass (Da):72,635
Last modified:November 1, 1996 - v1
Checksum:i43E1468F532E80CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62807 mRNA. Translation: AAB08760.1.
RefSeqiNP_001081462.1. NM_001087993.1.
UniGeneiXl.3204.

Genome annotation databases

GeneIDi397850.
KEGGixla:397850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62807 mRNA. Translation: AAB08760.1 .
RefSeqi NP_001081462.1. NM_001087993.1.
UniGenei Xl.3204.

3D structure databases

ProteinModelPortali Q91883.
SMRi Q91883. Positions 30-571.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q91883.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397850.
KEGGi xla:397850.

Phylogenomic databases

HOVERGENi HBG051845.
KOi K09490.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Degradation and endoplasmic reticulum retention of unassembled alpha- and beta-subunits of Na,K-ATPase correlate with interaction of BiP."
    Beggah A., Mathews P., Beguin P., Geering K.
    J. Biol. Chem. 271:20895-20902(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGRP78_XENLA
AccessioniPrimary (citable) accession number: Q91883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi