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Protein

Zinc finger protein 143

Gene

znf143

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the activator element (AE) motif of the selenocysteine tRNA gene promoter.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri230 – 25425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31425C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34425C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri350 – 37425C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40425C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43324C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 143
Alternative name(s):
Selenocysteine tRNA gene transcription-activating factor
Gene namesi
Name:znf143
Synonyms:staf
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1012509. znf143.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Zinc finger protein 143PRO_0000370719Add
BLAST

Family & Domainsi

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri230 – 25425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31425C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34425C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri350 – 37425C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40425C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43324C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91853-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLAQINRDS QAMAEFPGGG GEAQHVTLCL TEAVADGESM DTMEGMSLQA
60 70 80 90 100
VTLADGSTAY IQHNTKDGKL IEGQVIQLED GSAAYVQHVP KGDDLSLEDG
110 120 130 140 150
QAVQLEDGTT AYIHHSSKDS YDQSSVQAVQ LEDGTTAYIH HAVQVPQSDT
160 170 180 190 200
ILAIQADGTV AGLHTGEASI DPDTISALEQ YAAKVSIEGG EGAGSNALIN
210 220 230 240 250
ESESEKKMQI VLSHGARLPI KAQQTNEKAF RCDYEGCGKL YTTAHHLKVH
260 270 280 290 300
ERSHTGDRPY QCDHGSCRKA FATGYGLKSH VRTHTGEKPY RCSEENCTKS
310 320 330 340 350
FKTSGDLQKH VRTHTGERPF KCPFEGCGRS FTTSNIRKVH IRTHTGERPY
360 370 380 390 400
YCSEPGCGRA FASATNYKNH VRIHTGEKPY VCTVPGCDKR FTEYSSLYKH
410 420 430 440 450
HVVHTHSKPY NCNHCGKTYK QISTLAMHKR TAHNDTEPIE EDQESFFVPQ
460 470 480 490 500
PPDEVIKGSQ ITYVTGVDGE DGISATQSGQ QLALIAQDGT SHVAIVAQDL
510 520 530 540 550
SAFHNSETGP QHSHNLGGSD SRPVTLLATS NGRQIAVQIG EQQSLEEAIR
560
IASRIQQGES PGMED
Length:565
Mass (Da):61,418
Last modified:May 5, 2009 - v2
Checksum:iF83B5A070E2A0387
GO
Isoform 2 (identifier: Q91853-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-538: Missing.

Show »
Length:519
Mass (Da):56,654
Checksum:i3C6DAF54239F5392
GO

Sequence cautioni

The sequence AAH71051 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA59354 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei493 – 53846Missing in isoform 2. 1 PublicationVSP_036981Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84996 mRNA. Translation: CAA59354.1. Different initiation.
BC071051 mRNA. Translation: AAH71051.1. Different initiation.
PIRiS58681.
RefSeqiNP_001084373.1. NM_001090904.1.
UniGeneiXl.23822.

Genome annotation databases

GeneIDi399467.
KEGGixla:399467.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84996 mRNA. Translation: CAA59354.1. Different initiation.
BC071051 mRNA. Translation: AAH71051.1. Different initiation.
PIRiS58681.
RefSeqiNP_001084373.1. NM_001090904.1.
UniGeneiXl.23822.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399467.
KEGGixla:399467.

Organism-specific databases

CTDi7702.
XenbaseiXB-GENE-1012509. znf143.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN143_XENLA
AccessioniPrimary (citable) accession number: Q91853
Secondary accession number(s): Q6IR49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: January 7, 2015
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.