Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cadherin-20

Gene

cdh20

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-20
Alternative name(s):
F-cadherin
Gene namesi
Name:cdh20
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1011623. cdh20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 612ExtracellularSequence analysisAdd BLAST587
Transmembranei613 – 633HelicalSequence analysisAdd BLAST21
Topological domaini634 – 790CytoplasmicSequence analysisAdd BLAST157

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000034024526 – 52Sequence analysisAdd BLAST27
ChainiPRO_000034024653 – 790Cadherin-20Add BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi254N-linked (GlcNAc...)Sequence analysis1
Glycosylationi283N-linked (GlcNAc...)Sequence analysis1
Glycosylationi413N-linked (GlcNAc...)Sequence analysis1
Glycosylationi454N-linked (GlcNAc...)Sequence analysis1
Glycosylationi535N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Expressioni

Tissue specificityi

Detected in embryonic posterior neural plate, embryonic neural tube, sulcus limitans and embryonic kidney.2 Publications

Structurei

3D structure databases

ProteinModelPortaliQ91838.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 158Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini159 – 267Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini268 – 382Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini383 – 487Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini487 – 605Cadherin 5PROSITE-ProRule annotationAdd BLAST119

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005217.
KOiK06807.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCKRSYHRH CALVYYMVLL DLTNAVFEFS HPLIRDSGNS QSRQLLHHRL
60 70 80 90 100
KRSWVWNQFF VLEEYTGTEP LYVGKLHSDM DKGEGSITYI LSGDGAGTMF
110 120 130 140 150
TIDETTGDIH AIQRLDREER SQYTLKAQAL DRRTTRPMEP ESEFIVKIQD
160 170 180 190 200
INDNEPKFLD GPYTASVPEM SPVGTSIIQV SATDADDPTY GSSARVVYSI
210 220 230 240 250
LQGQPYFSVD SKTGIIRTAL TNMDRESRDY YEVIIQAKDM GGQLGGLAGT
260 270 280 290 300
TTVNVTLSDV NDNPPRFPQK HYQMSVLESL LINSTVGRVL AMDLDEGVNA
310 320 330 340 350
EMKYNIIDGD EFEVFDIVTD PSNQVGVITV KKPLDFETKK SYTLKIEGSN
360 370 380 390 400
AHLEIRFLNL GPFRDTTSVH ITVEDVDEPP VFGSSFYFVE VSENVDIGTT
410 420 430 440 450
IQIVSAKDPD ATNNSVRYSI DRSSDPGRYF YVDVTTGALM TARPLDREEV
460 470 480 490 500
SWHNITILAM EMNNPAQIGG VPVTIKVLDV NDNAPTFTKF SETLMCENAK
510 520 530 540 550
ADQLIQTVSA VDQDDPQEGQ HISYSLAPDA ANNPNFTLRD NQDNTAWILT
560 570 580 590 600
RRPGFKQSEQ STFYLPLLIS DNGNPRLSST GTLTIQVCSC DKDGDIMSCN
610 620 630 640 650
AEPYTLPISL SRGALIAILT CIFVLLVLVL LILSMRRHRK QPYTIDEEDN
660 670 680 690 700
VHENIVRYDD EGGGEEDTEA FDIAALWNPR EAHMGKTRQD MKPEIESLSR
710 720 730 740 750
YVTQTCRMDN NVHSYMLAKL YEADTDVCAP PFDSLQTYMF EGEGSVAHSL
760 770 780 790
SSLQSLSTDS EQSYDYLSDW GPRFKKLAEM YGTKDNNGSL
Length:790
Mass (Da):88,506
Last modified:November 1, 1996 - v1
Checksum:iC944348A20208A75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85330 mRNA. Translation: CAA59679.1.
PIRiI51638.
RefSeqiNP_001131054.1. NM_001137582.1.
UniGeneiXl.153.

Genome annotation databases

GeneIDi100192361.
KEGGixla:100192361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85330 mRNA. Translation: CAA59679.1.
PIRiI51638.
RefSeqiNP_001131054.1. NM_001137582.1.
UniGeneiXl.153.

3D structure databases

ProteinModelPortaliQ91838.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100192361.
KEGGixla:100192361.

Organism-specific databases

CTDi28316.
XenbaseiXB-GENE-1011623. cdh20.

Phylogenomic databases

HOVERGENiHBG005217.
KOiK06807.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD20_XENLA
AccessioniPrimary (citable) accession number: Q91838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.