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Q91784 (KIF4_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chromosome-associated kinesin KIF4
Alternative name(s):
Chromokinesin
Chromosome-associated kinesin KLP1
Gene names
Name:kif4
Synonyms:kif4a, klp1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length1226 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for mitotic chromosomal positioning and bipolar spindle stabilization. Ref.1

Subcellular location

Nucleus. Chromosome. Cytoplasm › cytoskeleton Probable. Note: Associated with mitotic chromosomes. Ref.1

Tissue specificity

Expressed in oocytes, eggs, testes and brain. Ref.1

Sequence similarities

Belongs to the kinesin-like protein family. Chromokinesin subfamily.

Contains 1 kinesin-motor domain.

Ontologies

Keywords
   Cellular componentChromosome
Cytoplasm
Cytoskeleton
Microtubule
Nucleus
   DomainCoiled coil
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Molecular functionMotor protein
Gene Ontology (GO)
   Biological processmicrotubule-based movement

Inferred from electronic annotation. Source: InterPro

   Cellular componentchromosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule motor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12261226Chromosome-associated kinesin KIF4
PRO_0000125440

Regions

Domain1 – 350350Kinesin-motor
Nucleotide binding87 – 948ATP By similarity
Region1007 – 1226220Globular
Coiled coil351 – 1006656 Potential

Experimental info

Sequence conflict1631I → L Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q91784 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7F0275FCF3316697

FASTA1,226138,924
        10         20         30         40         50         60 
MGKDEGIPVR VALRCRPLVP KENNEGCKMC LTFVPGEQQV IVGTEKSFTY DYVFDPSAEQ 

        70         80         90        100        110        120 
EEVYNSAVAP LIKGLFKGYN ATVLAYGQTG SGKTYSMGGA YTHNQENEPT VGVIPRTVIA 

       130        140        150        160        170        180 
LFREIHQRPE WEFNLKVSYL EIYNEEILDL LYAARDKTNT ISIREDPKEG IKICGLTERD 

       190        200        210        220        230        240 
VKTALDTLSC LEQGNSSRTV ASTAMNSQSS RSHAIFTISI EQRKEGDKNN SFRSKLHLVD 

       250        260        270        280        290        300 
LAGSERQKKT KAEGDRLKEG ISINRGLLCL GNVISALGDE SKKGGFVPYR DSKLTRLLQD 

       310        320        330        340        350        360 
SLGGNSHTLM IACVSPADSN MEETLNTLRY ADRARKIKNK PIVNTDPQAA ELQRLKLQVQ 

       370        380        390        400        410        420 
ELQVLLLQAH GGTLPVLNSM EPSENLQSLM ERNKNLEKEN GKLSRELGEA AVQTAQFLEK 

       430        440        450        460        470        480 
IIMTEQQNEK LGSKMEELKQ HAACKVNLQR LVETLEDQEL KDNVEVIQNL QQVIVQLQDE 

       490        500        510        520        530        540 
SSGIAGSIEA MDEEAASFPV PEEDSGEKRS SDGFTTNHAL RQAQLSKELI ELNKALVMKE 

       550        560        570        580        590        600 
ALAKKMAQND RQLEPIQSEY LNNIKHLESE VGVLQKEKEE LILALHSAKK DNNQAKLSER 

       610        620        630        640        650        660 
RRKRLQELEG QMTELKKKLG EQSKLLKLRE STEKTVAKMN QEIQGMKMQR VQLMRQMKED 

       670        680        690        700        710        720 
AEKFRTWKQQ KTKEVIQLKE KDRKRQYELL KLERDFQKQA NVLRRKTEEA ASANKRLKEA 

       730        740        750        760        770        780 
LQRQKEAMEK RKDSQSKGME GAASRVKNWL ANEVEVLVST EEAQRHLNDL LEDRKILAQD 

       790        800        810        820        830        840 
IAQLKQKTDA GERIPTKIRR RTYTVAELEN LEEEASVTKQ IESLETEMEL RSAQIADLQQ 

       850        860        870        880        890        900 
KLLDADGEEE MVKRRWETIS NIMEAKCALK YLITELVSSK VAGSKLESSV KQNRAHVADL 

       910        920        930        940        950        960 
QKNIFEERNQ MAEMETEHQS QLMQLEQHHQ EKILYLLSQL QQKQASVPVT IEELPAEEIT 

       970        980        990       1000       1010       1020 
EREKQLMERL KFQDEEIEKM KALCEKNQQL LQENDMYKQK LALLHVASGK KLHNILPAAE 

      1030       1040       1050       1060       1070       1080 
ICSPDSPFDF IPPKPRGKRR TNAKSAAVIL EDLLSESESE EESDDKNWEP GNNSKQSKKL 

      1090       1100       1110       1120       1130       1140 
TSKCSCKARC GNKMCGCRKT KQNCSDDCFC DPSKCRNRDN HMDEGKHEDQ SLESENSKID 

      1150       1160       1170       1180       1190       1200 
YPDVTAGGSF FTPPCVTPTK KVLREISDIG QVLSIKLQRK PSTASASASV MESQENQTSI 

      1210       1220 
LTKKKKVLCN SNTSFFSGCS AITEDE

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References

[1]"Xklp1, a chromosomal Xenopus kinesin-like protein essential for spindle organization and chromosome positioning."
Vernos I., Raats J., Hirano T., Heasman J., Karsenti E., Wylie C.
Cell 81:117-127(1995) [PubMed: 7720067] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Oocyte.
[2]"Multiple kinesin-like transcripts in Xenopus oocytes."
Vernos I., Heasman J., Wylie C.
Dev. Biol. 157:232-239(1993) [PubMed: 8482413] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-338.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X82012 mRNA. Translation: CAA57539.1.
PIRI51617.
RefSeqNP_001081019.1. NM_001087550.1.
UniGeneXl.1232.

3D structure databases

ProteinModelPortalQ91784.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-48591N.
IntActQ91784. 1 interaction.

Proteomic databases

PRIDEQ91784.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID394332.
KEGGxla:394332.

Organism-specific databases

CTD24137.
XenbaseXB-GENE-6079277. kif4a.

Phylogenomic databases

HOVERGENHBG052256.

Family and domain databases

InterProIPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
[Graphical view]
Gene3DG3DSA:3.40.850.10. kinesin_motor. 1 hit.
KOK10395.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
PROSITEPS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKIF4_XENLA
AccessionPrimary (citable) accession number: Q91784
Secondary accession number(s): Q9PSI0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: November 16, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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