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Protein

Chromosome-associated kinesin KIF4

Gene

kif4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for mitotic chromosomal positioning and bipolar spindle stabilization.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi87 – 948ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome-associated kinesin KIF4
Alternative name(s):
Chromokinesin
Chromosome-associated kinesin KLP1
Gene namesi
Name:kif4
Synonyms:kif4a, klp1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6079277. kif4a.

Subcellular locationi

  • Nucleus 1 Publication
  • Chromosome 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

  • Note: Associated with mitotic chromosomes.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12261226Chromosome-associated kinesin KIF4PRO_0000125440Add
BLAST

Proteomic databases

PRIDEiQ91784.

Expressioni

Tissue specificityi

Expressed in oocytes, eggs, testes and brain.1 Publication

Interactioni

Protein-protein interaction databases

DIPiDIP-48591N.
IntActiQ91784. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ91784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 337330Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1007 – 1226220GlobularAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili351 – 1006656Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG052256.
KOiK10395.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM01114. CXC. 1 hit.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKDEGIPVR VALRCRPLVP KENNEGCKMC LTFVPGEQQV IVGTEKSFTY
60 70 80 90 100
DYVFDPSAEQ EEVYNSAVAP LIKGLFKGYN ATVLAYGQTG SGKTYSMGGA
110 120 130 140 150
YTHNQENEPT VGVIPRTVIA LFREIHQRPE WEFNLKVSYL EIYNEEILDL
160 170 180 190 200
LYAARDKTNT ISIREDPKEG IKICGLTERD VKTALDTLSC LEQGNSSRTV
210 220 230 240 250
ASTAMNSQSS RSHAIFTISI EQRKEGDKNN SFRSKLHLVD LAGSERQKKT
260 270 280 290 300
KAEGDRLKEG ISINRGLLCL GNVISALGDE SKKGGFVPYR DSKLTRLLQD
310 320 330 340 350
SLGGNSHTLM IACVSPADSN MEETLNTLRY ADRARKIKNK PIVNTDPQAA
360 370 380 390 400
ELQRLKLQVQ ELQVLLLQAH GGTLPVLNSM EPSENLQSLM ERNKNLEKEN
410 420 430 440 450
GKLSRELGEA AVQTAQFLEK IIMTEQQNEK LGSKMEELKQ HAACKVNLQR
460 470 480 490 500
LVETLEDQEL KDNVEVIQNL QQVIVQLQDE SSGIAGSIEA MDEEAASFPV
510 520 530 540 550
PEEDSGEKRS SDGFTTNHAL RQAQLSKELI ELNKALVMKE ALAKKMAQND
560 570 580 590 600
RQLEPIQSEY LNNIKHLESE VGVLQKEKEE LILALHSAKK DNNQAKLSER
610 620 630 640 650
RRKRLQELEG QMTELKKKLG EQSKLLKLRE STEKTVAKMN QEIQGMKMQR
660 670 680 690 700
VQLMRQMKED AEKFRTWKQQ KTKEVIQLKE KDRKRQYELL KLERDFQKQA
710 720 730 740 750
NVLRRKTEEA ASANKRLKEA LQRQKEAMEK RKDSQSKGME GAASRVKNWL
760 770 780 790 800
ANEVEVLVST EEAQRHLNDL LEDRKILAQD IAQLKQKTDA GERIPTKIRR
810 820 830 840 850
RTYTVAELEN LEEEASVTKQ IESLETEMEL RSAQIADLQQ KLLDADGEEE
860 870 880 890 900
MVKRRWETIS NIMEAKCALK YLITELVSSK VAGSKLESSV KQNRAHVADL
910 920 930 940 950
QKNIFEERNQ MAEMETEHQS QLMQLEQHHQ EKILYLLSQL QQKQASVPVT
960 970 980 990 1000
IEELPAEEIT EREKQLMERL KFQDEEIEKM KALCEKNQQL LQENDMYKQK
1010 1020 1030 1040 1050
LALLHVASGK KLHNILPAAE ICSPDSPFDF IPPKPRGKRR TNAKSAAVIL
1060 1070 1080 1090 1100
EDLLSESESE EESDDKNWEP GNNSKQSKKL TSKCSCKARC GNKMCGCRKT
1110 1120 1130 1140 1150
KQNCSDDCFC DPSKCRNRDN HMDEGKHEDQ SLESENSKID YPDVTAGGSF
1160 1170 1180 1190 1200
FTPPCVTPTK KVLREISDIG QVLSIKLQRK PSTASASASV MESQENQTSI
1210 1220
LTKKKKVLCN SNTSFFSGCS AITEDE
Length:1,226
Mass (Da):138,924
Last modified:November 1, 1996 - v1
Checksum:i7F0275FCF3316697
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti163 – 1631I → L (PubMed:8482413).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82012 mRNA. Translation: CAA57539.1.
PIRiI51617.
RefSeqiNP_001081019.1. NM_001087550.1.
UniGeneiXl.1232.

Genome annotation databases

GeneIDi394332.
KEGGixla:394332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82012 mRNA. Translation: CAA57539.1.
PIRiI51617.
RefSeqiNP_001081019.1. NM_001087550.1.
UniGeneiXl.1232.

3D structure databases

ProteinModelPortaliQ91784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48591N.
IntActiQ91784. 1 interaction.

Proteomic databases

PRIDEiQ91784.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi394332.
KEGGixla:394332.

Organism-specific databases

CTDi24137.
XenbaseiXB-GENE-6079277. kif4a.

Phylogenomic databases

HOVERGENiHBG052256.
KOiK10395.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM01114. CXC. 1 hit.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Xklp1, a chromosomal Xenopus kinesin-like protein essential for spindle organization and chromosome positioning."
    Vernos I., Raats J., Hirano T., Heasman J., Karsenti E., Wylie C.
    Cell 81:117-127(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Oocyte.
  2. "Multiple kinesin-like transcripts in Xenopus oocytes."
    Vernos I., Heasman J., Wylie C.
    Dev. Biol. 157:232-239(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-338.

Entry informationi

Entry nameiKIF4_XENLA
AccessioniPrimary (citable) accession number: Q91784
Secondary accession number(s): Q9PSI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.