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Q91757

- GSK3B_XENLA

UniProt

Q91757 - GSK3B_XENLA

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Protein

Glycogen synthase kinase-3 beta

Gene

gsk3b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in the organization of the formation of the main body axis of developing embryo. Acts as an inhibitor of differentiation of primary neurons. Inhibits the ability of ectopically expressed NEUROD1 and other bHLH factors to promote early retinal cell differentiation. May participate in the Wnt signaling pathway. May regulate the circadian clock via phosphorylation of the major clock components.4 Publications

Catalytic activityi

ATP + [tau protein] = ADP + [tau protein] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851ATPPROSITE-ProRule annotation
Active sitei181 – 1811Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 709ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB
  3. tau-protein kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. canonical Wnt signaling pathway Source: BHF-UCL
  2. cell differentiation Source: UniProtKB-KW
  3. negative regulation of transcription, DNA-templated Source: BHF-UCL
  4. nervous system development Source: UniProtKB-KW
  5. rhythmic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Biological rhythms, Differentiation, Neurogenesis, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen synthase kinase-3 beta (EC:2.7.11.26)
Short name:
GSK-3 beta
Alternative name(s):
Xgsk-3 protein
Gene namesi
Name:gsk3b
Synonyms:Xgsk-3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865674. gsk3b.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Cell membrane By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi85 – 851K → R: Inhibits enzymatic activity. Induces duplication of the anterior dorsal axis. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Glycogen synthase kinase-3 betaPRO_0000412070Add
BLAST

Post-translational modificationi

Phosphorylated. Activated by phosphorylation at Tyr-216.

Keywords - PTMi

Phosphoprotein

Expressioni

Developmental stagei

Expressed in the unfertilized egg and throughout the early embryonic stages. Expressed in the neural plate at stage 13. Expressed throughout the eye primordia and cranial ganglia at stage 25. Highly expressed in the differentiated retinal ganglion cell layer at stage 40.3 Publications

Interactioni

Protein-protein interaction databases

MINTiMINT-100944.

Structurei

3D structure databases

ProteinModelPortaliQ91757.
SMRiQ91757. Positions 28-383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 340285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG014652.
KOiK03083.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91757-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGRPRTTSF AESCKPVQQP SSFGSMKVSR DKDGSKVTTV VATPGQGPDR
60 70 80 90 100
QQEVTYTDTK VIGNGSFGVV YQAKLCDTGE LVAIKKVLQD KRFKNRELQI
110 120 130 140 150
MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK
160 170 180 190 200
QALPIIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PETAVLKLCD
210 220 230 240 250
FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL
260 270 280 290 300
LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
310 320 330 340 350
WTKVFRARTP PEAIALCSRL LEYTPTSRLT PLDACAHSFF DELRDPNLKL
360 370 380 390 400
PNGREFPALF NFTTQELSSN PSLSSILIPA HARNQAAVST TSNTTSTSDS
410 420
NTGERGSTNN AASASASNSS
Length:420
Mass (Da):46,903
Last modified:November 1, 1996 - v1
Checksum:iC02280BB8A35785D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551T → S in AAA84444. (PubMed:7667318)Curated
Sequence conflicti88 – 881L → P in AAA84444. (PubMed:7667318)Curated
Sequence conflicti336 – 3361A → V in AAA84444. (PubMed:7667318)Curated
Sequence conflicti399 – 3991D → N in AAA84444. (PubMed:7667318)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38492 mRNA. Translation: AAC42224.1.
U31862 mRNA. Translation: AAA84444.1.
BC108581 mRNA. Translation: AAI08582.1.
PIRiI51425.
I51692.
RefSeqiNP_001083752.1. NM_001090283.1.
UniGeneiXl.324.

Genome annotation databases

GeneIDi399097.
KEGGixla:399097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38492 mRNA. Translation: AAC42224.1 .
U31862 mRNA. Translation: AAA84444.1 .
BC108581 mRNA. Translation: AAI08582.1 .
PIRi I51425.
I51692.
RefSeqi NP_001083752.1. NM_001090283.1.
UniGenei Xl.324.

3D structure databases

ProteinModelPortali Q91757.
SMRi Q91757. Positions 28-383.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-100944.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399097.
KEGGi xla:399097.

Organism-specific databases

CTDi 2932.
Xenbasei XB-GENE-865674. gsk3b.

Phylogenomic databases

HOVERGENi HBG014652.
KOi K03083.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3."
    Pierce S.B., Kimelman D.
    Development 121:755-765(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF LYS-85, DEVELOPMENTAL STAGE.
  2. "Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos."
    Dominguez I., Itoh K., Sokol S.Y.
    Proc. Natl. Acad. Sci. U.S.A. 92:8498-8502(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF LYS-85, DEVELOPMENTAL STAGE.
  3. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  4. "The role of GSK3beta in regulating neuronal differentiation in Xenopus laevis."
    Marcus E.A., Kintner C., Harris W.
    Mol. Cell. Neurosci. 12:269-280(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  5. "Posttranslational mechanisms control the timing of bHLH function and regulate retinal cell fate."
    Moore K.B., Schneider M.L., Vetter M.L.
    Neuron 34:183-195(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGSK3B_XENLA
AccessioniPrimary (citable) accession number: Q91757
Secondary accession number(s): Q91627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3