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Protein

Glycogen synthase kinase-3 beta

Gene

gsk3b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the organization of the formation of the main body axis of developing embryo. Acts as an inhibitor of differentiation of primary neurons. Inhibits the ability of ectopically expressed NEUROD1 and other bHLH factors to promote early retinal cell differentiation. May participate in the Wnt signaling pathway. May regulate the circadian clock via phosphorylation of the major clock components.4 Publications

Catalytic activityi

ATP + [tau protein] = ADP + [tau protein] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85ATPPROSITE-ProRule annotation1
Active sitei181Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 70ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • canonical Wnt signaling pathway Source: BHF-UCL
  • cell differentiation Source: UniProtKB-KW
  • negative regulation of transcription, DNA-templated Source: BHF-UCL
  • nervous system development Source: UniProtKB-KW
  • rhythmic process Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processBiological rhythms, Differentiation, Neurogenesis, Wnt signaling pathway
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen synthase kinase-3 beta (EC:2.7.11.26)
Short name:
GSK-3 beta
Alternative name(s):
Xgsk-3 protein
Gene namesi
Name:gsk3b
Synonyms:Xgsk-3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865674. gsk3b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi85K → R: Inhibits enzymatic activity. Induces duplication of the anterior dorsal axis. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004120701 – 420Glycogen synthase kinase-3 betaAdd BLAST420

Post-translational modificationi

Phosphorylated. Activated by phosphorylation at Tyr-216.

Keywords - PTMi

Phosphoprotein

Expressioni

Developmental stagei

Expressed in the unfertilized egg and throughout the early embryonic stages. Expressed in the neural plate at stage 13. Expressed throughout the eye primordia and cranial ganglia at stage 25. Highly expressed in the differentiated retinal ganglion cell layer at stage 40.3 Publications

Interactioni

Protein-protein interaction databases

ELMiQ91757.
MINTiMINT-100944.

Structurei

3D structure databases

ProteinModelPortaliQ91757.
SMRiQ91757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 340Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG014652.
KOiK03083.

Family and domain databases

InterProiView protein in InterPro
IPR033573. GSK3B.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PANTHERiPTHR24057:SF8. PTHR24057:SF8. 1 hit.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRPRTTSF AESCKPVQQP SSFGSMKVSR DKDGSKVTTV VATPGQGPDR
60 70 80 90 100
QQEVTYTDTK VIGNGSFGVV YQAKLCDTGE LVAIKKVLQD KRFKNRELQI
110 120 130 140 150
MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK
160 170 180 190 200
QALPIIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PETAVLKLCD
210 220 230 240 250
FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL
260 270 280 290 300
LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
310 320 330 340 350
WTKVFRARTP PEAIALCSRL LEYTPTSRLT PLDACAHSFF DELRDPNLKL
360 370 380 390 400
PNGREFPALF NFTTQELSSN PSLSSILIPA HARNQAAVST TSNTTSTSDS
410 420
NTGERGSTNN AASASASNSS
Length:420
Mass (Da):46,903
Last modified:November 1, 1996 - v1
Checksum:iC02280BB8A35785D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55T → S in AAA84444 (PubMed:7667318).Curated1
Sequence conflicti88L → P in AAA84444 (PubMed:7667318).Curated1
Sequence conflicti336A → V in AAA84444 (PubMed:7667318).Curated1
Sequence conflicti399D → N in AAA84444 (PubMed:7667318).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38492 mRNA. Translation: AAC42224.1.
U31862 mRNA. Translation: AAA84444.1.
BC108581 mRNA. Translation: AAI08582.1.
PIRiI51425.
I51692.
RefSeqiNP_001083752.1. NM_001090283.1.
XP_018100414.1. XM_018244925.1.
UniGeneiXl.324.

Genome annotation databases

GeneIDi399097.
KEGGixla:399097.

Similar proteinsi

Entry informationi

Entry nameiGSK3B_XENLA
AccessioniPrimary (citable) accession number: Q91757
Secondary accession number(s): Q91627
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families