Q91753 (Q91753_XENLA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glucokinase EMBL CAA63761.1

Gene names

Name:	gck Xenbase XB-GENE-981994
Synonyms:	gck-A EMBL AAI69458.1

Organism

Xenopus laevis (African clawed frog) EMBL CAA63761.1

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the hexokinase family. RuleBase RU004510

Ontologies

Keywords
Biological process	Glycolysis SAAS SAAS001312 RuleBase RU004049
Ligand	ATP-binding SAAS SAAS001312 RuleBase RU004049 Nucleotide-binding
Molecular function	Kinase SAAS SAAS001312 RuleBase RU004049 EMBL CAA63761.1 Transferase
Gene Ontology (GO)
Biological_process	detection of glucose Inferred from sequence or structural similarity. Source: UniProtKB glucose homeostasis Inferred from sequence or structural similarity. Source: UniProtKB glycolysis Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of gluconeogenesis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of glycogen biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of insulin secretion Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from sequence or structural similarity. Source: UniProtKB glucokinase activity Inferred from sequence or structural similarity. Source: UniProtKB glucose binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q91753 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5C4E695C4115E4B6	FASTA	458	51,087
	10 20 30 40 50 60 METFDQNEVD QILSEFHLQE EDLHVLMCRM QAEMERGLHL ETNEEASVKM LPTYVRSTPD 70 80 90 100 110 120 GSEVGDFLAL DLGGTNFRVM LVKVGEDLEG QWKVETKHKM YSIPVDAMTG TAEMLFDYIA 130 140 150 160 170 180 ECISDYLDQQ NMKHKKLPLG FTFSFPVRHE DIDKGILLNW TKGFKASGAE GNNVVGLLRD 190 200 210 220 230 240 AIKRRGDFEM DVVAMVNDTV ATMISCYYED HHCEVGLIVG TGCNACYMEE MSNVELVEGE 250 260 270 280 290 300 EGRMCVNTEW GAFGDTGELE DFRLEYDRVV DEASLNPGQQ LYEKMIGGKY MGELVRLVLI 310 320 330 340 350 360 KMVNENLLFG GESSEKLKTR GAFETQFVSQ IEADTSDFKQ TLNILRTLGV QATIGDCHAV 370 380 390 400 410 420 RLACESVSTR AAIMCSAGLA GILNRMRQSR REELLRITVG VDGSVYKLHP SFKDKFHATV 430 440 450 LKLTSGCEIT FIQSEEGSGR GAALISAVAY KMAVMIGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Amino acid conservation in animal glucokinases. Identification of residues implicated in the interaction with the regulatory protein." Veiga-da-Cunha M., Courtois S., Michel A., Gosselain E., Van Schaftingen E. J. Biol. Chem. 271:6292-6297(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Oocytes EMBL AAI69458.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC169458 mRNA. Translation: AAI69458.1. BC170499 mRNA. Translation: AAI70499.1. X93494 mRNA. Translation: CAA63761.1.
RefSeq	NP_001079298.1. NM_001085829.1.
UniGene	Xl.1193.
3D structure databases
SMR	Q91753. Positions 9-453.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	378602.
KEGG	xla:378602.
Organism-specific databases
CTD	2645.
Xenbase	XB-GENE-981994. gck.
Phylogenomic databases
HOVERGEN	HBG000142.
KO	K12407.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. PTHR19443. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q91753_XENLA

Accession

Primary (citable) accession number: Q91753

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)