Reviewed, UniProtKB/Swiss-Prot Q91736 (EPB1B_XENLA)

Names and origin

Protein names

Recommended name:
    Ephrin type-B receptor 1-B
    EC=2.7.10.1
Alternative name(s):
    Tyrosine-protein kinase receptor XELK

Gene names

Name:	ephb1-B
Synonyms:	xelk

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	902 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for members of the ephrin-B family By similarity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed in the embryo in the brain and spinal cord and in the first and fourth visceral arches. Most abundant in adult brain, with lower levels in eye, heart, ovary, oviduct, lung and pharynx.
Developmental stage	Expressed during early development.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ephrin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 902	›902	Ephrin type-B receptor 1-B		PRO_0000160275
Regions
	Topological domain	‹1 – 459	›459	Extracellular Potential
	Transmembrane	460 – 480	21	Potential
	Topological domain	481 – 902	422	Cytoplasmic Potential
	Domain	241 – 342	102	Fibronectin type-III 1
	Domain	352 – 443	92	Fibronectin type-III 2
	Domain	537 – 800	264	Protein kinase
	Domain	829 – 893	65	SAM
	Nucleotide binding	543 – 551	9	ATP By similarity
	Motif	900 – 902	3	PDZ-binding Potential
	Compositional bias	101 – 237	137	Cys-rich
Sites
	Active site	662	1	Proton acceptor By similarity
	Binding site	569	1	ATP By similarity
Amino acid modifications
	Glycosylation	252	1	N-linked (GlcNAc...) Potential
	Glycosylation	344	1	N-linked (GlcNAc...) Potential
	Glycosylation	398	1	N-linked (GlcNAc...) Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q91736-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: CCB9ABF7D39273CA	FASTA	902	100,851
	10 20 30 40 50 60 HRVYVEMRFT VRDCSSLPNV PGSCKETFNL YYYETDSNID NKISTFWNES PYLKVDTIAA 70 80 90 100 110 120 DESFSQVDFG GRLMKVNTEV RSFGPLTRSG FYLAFQDYGA CMSLLSVRVF FKKCPSVVQN 130 140 150 160 170 180 FAVFPETMTG AESTSLVIAR GTCIPNAEEV DVPIKLYCNG DGEWMVPIGK CTCKAGYEPE 190 200 210 220 230 240 NHVVCKACPA AMFKANQGMG ICAQCPANSR STSEASPICI CRNGYYRADF DTPEAPCTSV 250 260 270 280 290 300 PSGPRNVISI VNETAITLEW HPPRETGGRD DVNYNIICKK CQSDRRGCSH CDDNVDFVPR 310 320 330 340 350 360 QLGLTDTRVF ISNLWVHTPY TFEIQAVNGV TNKSPFPPQH VSVNITTNQA APSSVPIMHQ 370 380 390 400 410 420 VKATMKSITL SWPQPEQPNG IILDYEIRYY EKDHHEFNSS LARSQTNTAS IEGLRPGVVY 430 440 450 460 470 480 VVQVRARTVA GYGKFSSKMC FQTLTEEDYK SELREQLPLI AGSAAAGVVF IVSLVAISIV 490 500 510 520 530 540 CSRKRTYSKE AVYSDKLQHY STGRGSPGMK IYIDPFTYED PNEAVREFAK EIDVSFVKIE 550 560 570 580 590 600 EVIGAGEFGE VYKGRLKLPS KREISVAIKT LKAGYSEKQR RDFLSEASIM GQFDHPNIIR 610 620 630 640 650 660 LEGVVTKSRP VMIITEFMEN GALDSFLRQN DGQFTVIQLV GMLRGIAAGM KYLSEMNYVH 670 680 690 700 710 720 RDLAARNILV NSNLVCKVSD FGLSRYLQDD TSDPTYTSSL GGKIPVRWTA PEAIRYRKFT 730 740 750 760 770 780 SASDVWSYGI VMWEVMSYGE RPYWDMSNQD VINAIEQDYR LPPPMDCPAA LHQLMLDCWQ 790 800 810 820 830 840 KDRNSRPRFG EIVNTLDKMI RNPASLKTVA TIPAVPSQPL LDRSIPDISA FTSVDDWLSA 850 860 870 880 890 900 IKMGQYRDNF LSSGFTSLHV VAQMTSEDLL RIGITLAGHQ KKILNSIQSM RVQISQSPTS IA

References

[1]	"Novel members of the eph receptor tyrosine kinase subfamily expressed during Xenopus development." Scales J.B., Winning R.S., Renaud C.S., Shea L.J., Sargent T.D. Oncogene 11:1745-1752(1995) [PubMed: 7478602] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	L43621 mRNA. Translation: AAA93527.1.
3D structure databases
HSSP	HSSP built from PDB template 1JPA based on UniProtKB P54763.
SMR	Q91736. Positions 1-115, 354-446, 510-807.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q91736.
Enzyme and pathway databases
BRENDA	2.7.10.1. 648.
Family and domain databases
InterPro	IPR013032. EGF-like_reg_CS. IPR001090. Ephrin_rcpt_lig-bd. IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003962. FnIII_subd. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR001660. SAM. IPR013761. SAM_type. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. IPR016257. TyrPK_ephrin_receptor. IPR001426. YKase_receptorV_CS. [Graphical view]
Gene3D	G3DSA:2.60.40.30. FN_III-like. 2 hits. G3DSA:1.10.150.50. SAM_type. 1 hit.
Pfam	PF01404. Ephrin_lbd. 1 hit. PF00041. fn3. 2 hits. PF07714. Pkinase_Tyr. 1 hit. PF00536. SAM_1. 1 hit. [Graphical view]
PIRSF	PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTS	PR00014. FNTYPEIII. PR00109. TYRKINASE.
ProDom	PD001495. Ephrin_receptor. 1 hit. PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00615. EPH_lbd. 1 hit. SM00060. FN3. 2 hits. SM00454. SAM. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS01186. EGF_2. 1 hit. Uncertain. PS50853. FN3. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit. PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit. PS50105. SAM_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EPB1B_XENLA

Accession

Primary (citable) accession number: Q91736

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project