Reviewed,
UniProtKB/Swiss-Prot Q91735 (EPHB3_XENLA)
Last modified
February 9, 2010.
Version 91.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ephrin type-B receptor 3 EC=2.7.10.1 Alternative name(s): Tyrosine-protein kinase receptor TCK | ||||
| Gene names |
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| Organism | Xenopus laevis (African clawed frog) | ||||
| Taxonomic identifier | 8355 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Protein attributes
| Sequence length | 974 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Receptor for members of the ephrin-B family By similarity. |
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Subcellular location | |
| Tissue specificity | Expressed in the embryo in pre-somitic mesoderm, caudal somites, midbrain, and cement gland. Most abundant in adult brain, eye, heart, lung and ovary. Lower levels in intestine, kidney, oviduct and pharynx. |
| Developmental stage | Expressed during early development. |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Repeat Signal Transmembrane |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Receptor Transferase Tyrosine-protein kinase |
| PTM | Disulfide bond Glycoprotein Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathwayInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to plasma membrane Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ephrin receptor activityInferred from electronic annotation. Source: InterPro protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 16 | 16 | Potential | ||||||||
| Chain | 17 – 974 | 958 | Ephrin type-B receptor 3 | PRO_0000016833 | |||||||
Regions | |||||||||||
| Topological domain | 17 – 534 | 518 | Extracellular Potential | ||||||||
| Transmembrane | 535 – 555 | 21 | Potential | ||||||||
| Topological domain | 556 – 974 | 419 | Cytoplasmic Potential | ||||||||
| Domain | 319 – 418 | 100 | Fibronectin type-III 1 | ||||||||
| Domain | 424 – 518 | 95 | Fibronectin type-III 2 | ||||||||
| Domain | 609 – 872 | 264 | Protein kinase | ||||||||
| Domain | 901 – 965 | 65 | SAM | ||||||||
| Nucleotide binding | 615 – 623 | 9 | ATP By similarity | ||||||||
| Motif | 972 – 974 | 3 | PDZ-binding Potential | ||||||||
| Compositional bias | 178 – 315 | 138 | Cys-rich | ||||||||
Sites | |||||||||||
| Active site | 734 | 1 | Proton acceptor By similarity | ||||||||
| Binding site | 641 | 1 | ATP By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 330 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 420 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 60 ↔ 95 | By similarity | |||||||||
Sequences
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References
| [1] | "Novel members of the eph receptor tyrosine kinase subfamily expressed during Xenopus development." Scales J.B., Winning R.S., Renaud C.S., Shea L.J., Sargent T.D. Oncogene 11:1745-1752(1995) [PubMed: 7478602] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L43620 mRNA. Translation: AAA93526.1. |
| RefSeq | NP_001081434.1. |
| UniGene | Xl.1027 |
3D structure databases | |
| SMR | Q91735. Positions 17-193, 310-430, 317-522, 582-879, 890-969. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 397834. |
| KEGG | xla:397834. |
Phylogenomic databases | |
| HOVERGEN | Q91735. |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.1. 648. |
Family and domain databases | |
| InterPro | IPR001090. Ephrin_rcpt_lig-bd. IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003962. FnIII_subd. IPR008979. Galactose-bd-like. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001660. SAM. IPR011510. SAM_2. IPR010993. SAM_homology. IPR013761. SAM_type. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. IPR016257. Tyr_prot_kinase_ephrin_rcpt. IPR001426. Tyr_prot_kinase_rcpt_V_CS. [Graphical view] |
| Gene3D | G3DSA:2.60.40.30. FN_III-like. 1 hit. G3DSA:1.10.150.50. SAM_type. 1 hit. |
| PANTHER | PTHR23256. Tyr_prot_kinase. 1 hit. |
| Pfam | PF01404. Ephrin_lbd. 1 hit. PF00041. fn3. 2 hits. PF07647. SAM_2. 1 hit. [Graphical view] |
| PIRSF | PIRSF000666. TyrPK_ephrin_receptor. 1 hit. |
| PRINTS | PR00014. FNTYPEIII. |
| SMART | SM00615. EPH_lbd. 1 hit. SM00060. FN3. 2 hits. SM00454. SAM. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view] |
| PROSITE | PS50853. FN3. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit. PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit. PS50105. SAM_DOMAIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | EPHB3_XENLA | ||||||||
| Accession | Primary (citable) accession number: Q91735 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Xenopus annotation project | ||||||||

Clusters with


