Q91727 (CDK4_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase 4
EC=2.7.11.22

Alternative name(s):
Cell division protein kinase 4

Gene names

Name:

cdk4

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probably involved in the control of the cell cycle.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Phosphorylation at Thr-172 is necessary for enzymatic activity By similarity.
Subunit structure	Forms a stable complex with D-type G1 cyclins By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Cyclin-dependent kinase 4		PRO_0000085782
Regions
	Domain	9 – 295	287	Protein kinase
	Nucleotide binding	15 – 23	9	ATP By similarity
Sites
	Active site	140	1	Proton acceptor By similarity
	Binding site	38	1	ATP By similarity
Amino acid modifications
	Modified residue	172	1	Phosphothreonine; by CAK By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91727 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 235329790C4022A7	FASTA	319	35,684
	10 20 30 40 50 60 MSKEMKGQYE PVAEIGVGAY GTVYKARDLQ SGKFVALKNV RVQTNENGLP LSTVREVTLL 70 80 90 100 110 120 KRLEHFDHPN IVKLMDVCAS ARTDRETKVT LVFEHVDQDL KTYLSKVPPP GLPLETIKDL 130 140 150 160 170 180 MKQFLSGLEF LHLNCIVHRD LKPENILVTS GGQVKLADFG LARIYSCQMA LTPVVVTLWY 190 200 210 220 230 240 RAPEVLLQST YATPVDVWSA GCIFAEMFKR KPLFCGNSEA DQLCKIFDII GLPSEEEWPV 250 260 270 280 290 300 DVTLPRSAFS PRTQQPVDKF VPEIDAMGAD LLLAMLTFSP QKRISASDAL LHPFFADDPQ 310 ACSKQEHFTH ICTATDEVK

References

[1]	"D-type cyclins in Xenopus laevis." Cockerill M.J., Hunt T. Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X89477 mRNA. Translation: CAA61666.1.
PIR	S57926.
RefSeq	NP_001079719.1. NM_001086250.1.
UniGene	Xl.46102.
3D structure databases
ProteinModelPortal	Q91727.
SMR	Q91727. Positions 8-297.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4507150.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	379406.
KEGG	xla:379406.
Organism-specific databases
CTD	1019.
Xenbase	XB-GENE-5900736. cdk4.
Phylogenomic databases
HOVERGEN	HBG014652.
KO	K02089.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDK4_XENLA

Accession

Primary (citable) accession number: Q91727

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program