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Q91727 (CDK4_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 4

EC=2.7.11.22
Alternative name(s):
Cell division protein kinase 4
Gene names
Name:cdk4
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably involved in the control of the cell cycle.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Phosphorylation at Thr-172 is necessary for enzymatic activity By similarity.

Subunit structure

Forms a stable complex with D-type G1 cyclins By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ccnd1P507552EBI-7270544,EBI-7270567
ccnd1Q6GLD32EBI-7270544,EBI-7270670From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Cyclin-dependent kinase 4
PRO_0000085782

Regions

Domain9 – 295287Protein kinase
Nucleotide binding15 – 239ATP By similarity

Sites

Active site1401Proton acceptor By similarity
Binding site381ATP By similarity

Amino acid modifications

Modified residue1721Phosphothreonine; by CAK By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91727 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 235329790C4022A7

FASTA31935,684
        10         20         30         40         50         60 
MSKEMKGQYE PVAEIGVGAY GTVYKARDLQ SGKFVALKNV RVQTNENGLP LSTVREVTLL 

        70         80         90        100        110        120 
KRLEHFDHPN IVKLMDVCAS ARTDRETKVT LVFEHVDQDL KTYLSKVPPP GLPLETIKDL 

       130        140        150        160        170        180 
MKQFLSGLEF LHLNCIVHRD LKPENILVTS GGQVKLADFG LARIYSCQMA LTPVVVTLWY 

       190        200        210        220        230        240 
RAPEVLLQST YATPVDVWSA GCIFAEMFKR KPLFCGNSEA DQLCKIFDII GLPSEEEWPV 

       250        260        270        280        290        300 
DVTLPRSAFS PRTQQPVDKF VPEIDAMGAD LLLAMLTFSP QKRISASDAL LHPFFADDPQ 

       310 
ACSKQEHFTH ICTATDEVK 

« Hide

References

[1]"D-type cyclins in Xenopus laevis."
Cockerill M.J., Hunt T.
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X89477 mRNA. Translation: CAA61666.1.
PIRS57926.
RefSeqNP_001079719.1. NM_001086250.1.
UniGeneXl.46102.

3D structure databases

ProteinModelPortalQ91727.
SMRQ91727. Positions 8-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ91727. 2 interactions.
MINTMINT-4507150.

Proteomic databases

PRIDEQ91727.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID379406.
KEGGxla:379406.

Organism-specific databases

CTD1019.
XenbaseXB-GENE-5900736. cdk4.

Phylogenomic databases

HOVERGENHBG014652.
KOK02089.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK4_XENLA
AccessionPrimary (citable) accession number: Q91727
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families