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Q91727

- CDK4_XENLA

UniProt

Q91727 - CDK4_XENLA

Protein

Cyclin-dependent kinase 4

Gene

cdk4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Probably involved in the control of the cell cycle.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Phosphorylation at Thr-172 is necessary for enzymatic activity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381ATPPROSITE-ProRule annotation
    Active sitei140 – 1401Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 239ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. protein binding Source: IntAct

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 4 (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 4
    Gene namesi
    Name:cdk4
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-5900736. cdk4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Cyclin-dependent kinase 4PRO_0000085782Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei172 – 1721Phosphothreonine; by CAKBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ91727.

    Interactioni

    Subunit structurei

    Forms a stable complex with D-type G1 cyclins.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ccnd1P507552EBI-7270544,EBI-7270567
    ccnd1Q6GLD32EBI-7270544,EBI-7270670From a different organism.

    Protein-protein interaction databases

    IntActiQ91727. 2 interactions.
    MINTiMINT-4507150.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91727.
    SMRiQ91727. Positions 8-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 295287Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG014652.
    KOiK02089.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91727-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKEMKGQYE PVAEIGVGAY GTVYKARDLQ SGKFVALKNV RVQTNENGLP    50
    LSTVREVTLL KRLEHFDHPN IVKLMDVCAS ARTDRETKVT LVFEHVDQDL 100
    KTYLSKVPPP GLPLETIKDL MKQFLSGLEF LHLNCIVHRD LKPENILVTS 150
    GGQVKLADFG LARIYSCQMA LTPVVVTLWY RAPEVLLQST YATPVDVWSA 200
    GCIFAEMFKR KPLFCGNSEA DQLCKIFDII GLPSEEEWPV DVTLPRSAFS 250
    PRTQQPVDKF VPEIDAMGAD LLLAMLTFSP QKRISASDAL LHPFFADDPQ 300
    ACSKQEHFTH ICTATDEVK 319
    Length:319
    Mass (Da):35,684
    Last modified:November 1, 1996 - v1
    Checksum:i235329790C4022A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89477 mRNA. Translation: CAA61666.1.
    PIRiS57926.
    RefSeqiNP_001079719.1. NM_001086250.1.
    UniGeneiXl.46102.

    Genome annotation databases

    GeneIDi379406.
    KEGGixla:379406.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89477 mRNA. Translation: CAA61666.1 .
    PIRi S57926.
    RefSeqi NP_001079719.1. NM_001086250.1.
    UniGenei Xl.46102.

    3D structure databases

    ProteinModelPortali Q91727.
    SMRi Q91727. Positions 8-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91727. 2 interactions.
    MINTi MINT-4507150.

    Proteomic databases

    PRIDEi Q91727.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 379406.
    KEGGi xla:379406.

    Organism-specific databases

    CTDi 1019.
    Xenbasei XB-GENE-5900736. cdk4.

    Phylogenomic databases

    HOVERGENi HBG014652.
    KOi K02089.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "D-type cyclins in Xenopus laevis."
      Cockerill M.J., Hunt T.
      Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCDK4_XENLA
    AccessioniPrimary (citable) accession number: Q91727
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3