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Protein

Cyclin-dependent kinase 4

Gene

cdk4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the control of the cell cycle.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylation at Thr-172 is necessary for enzymatic activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381ATPPROSITE-ProRule annotation
Active sitei140 – 1401Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 4
Gene namesi
Name:cdk4
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5900736. cdk4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Cyclin-dependent kinase 4PRO_0000085782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei172 – 1721Phosphothreonine; by CAKBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ91727.

Interactioni

Subunit structurei

Forms a stable complex with D-type G1 cyclins.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ccnd1P507552EBI-7270544,EBI-7270567
ccnd1Q6GLD32EBI-7270544,EBI-7270670From a different organism.

Protein-protein interaction databases

IntActiQ91727. 2 interactions.
MINTiMINT-4507150.

Structurei

3D structure databases

ProteinModelPortaliQ91727.
SMRiQ91727. Positions 8-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 295287Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG014652.
KOiK02089.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKEMKGQYE PVAEIGVGAY GTVYKARDLQ SGKFVALKNV RVQTNENGLP
60 70 80 90 100
LSTVREVTLL KRLEHFDHPN IVKLMDVCAS ARTDRETKVT LVFEHVDQDL
110 120 130 140 150
KTYLSKVPPP GLPLETIKDL MKQFLSGLEF LHLNCIVHRD LKPENILVTS
160 170 180 190 200
GGQVKLADFG LARIYSCQMA LTPVVVTLWY RAPEVLLQST YATPVDVWSA
210 220 230 240 250
GCIFAEMFKR KPLFCGNSEA DQLCKIFDII GLPSEEEWPV DVTLPRSAFS
260 270 280 290 300
PRTQQPVDKF VPEIDAMGAD LLLAMLTFSP QKRISASDAL LHPFFADDPQ
310
ACSKQEHFTH ICTATDEVK
Length:319
Mass (Da):35,684
Last modified:November 1, 1996 - v1
Checksum:i235329790C4022A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89477 mRNA. Translation: CAA61666.1.
PIRiS57926.
RefSeqiNP_001079719.1. NM_001086250.1.
UniGeneiXl.46102.

Genome annotation databases

GeneIDi379406.
KEGGixla:379406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89477 mRNA. Translation: CAA61666.1.
PIRiS57926.
RefSeqiNP_001079719.1. NM_001086250.1.
UniGeneiXl.46102.

3D structure databases

ProteinModelPortaliQ91727.
SMRiQ91727. Positions 8-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91727. 2 interactions.
MINTiMINT-4507150.

Proteomic databases

PRIDEiQ91727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379406.
KEGGixla:379406.

Organism-specific databases

CTDi1019.
XenbaseiXB-GENE-5900736. cdk4.

Phylogenomic databases

HOVERGENiHBG014652.
KOiK02089.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "D-type cyclins in Xenopus laevis."
    Cockerill M.J., Hunt T.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCDK4_XENLA
AccessioniPrimary (citable) accession number: Q91727
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.