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Q91695

- HDA1A_XENLA

UniProt

Q91695 - HDA1A_XENLA

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Protein

Probable histone deacetylase 1-A

Gene
hdac1-a
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Histone deacetylase that is only required during early steps of development. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei141 – 1411 By similarity

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histone deacetylase 1-A (EC:3.5.1.98)
Short name:
HD1-A
Alternative name(s):
AB21
HDM
Maternally-expressed histone deacetylase
Gene namesi
Name:hdac1-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252325. hdac1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Probable histone deacetylase 1-APRO_0000114691Add
BLAST

Proteomic databases

PRIDEiQ91695.

Expressioni

Tissue specificityi

Oocyte.1 Publication

Developmental stagei

Expressed both maternally and zygotically. Accumulates in previtellogenic oocytes and is maintained at constant level throughout oogenesis and into early embryogenesis. Declines through gastrula to neurula. Not detectable between neurula and tailbud, nor in adult tissues other than ovary.1 Publication

Interactioni

Subunit structurei

Part of a large multiprotein complex that also contains RBBP4.

Structurei

3D structure databases

ProteinModelPortaliQ91695.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 321312Histone deacetylaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi299 – 3024Poly-Gly

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG057112.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q91695-1 [UniParc]FASTAAdd to Basket

« Hide

MALTLGTKKK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK    50
MEIFRPHKAS AEDMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC 100
PVFDGLFEFC QLSAGGSVAS AVKLNKQQTD ISVNWSGGLH HAKKSEASGF 150
CYVNDIVLAI LELLKYHQRV VYIDIDIHHG DGVEEAFYTT DRVMTVSFHK 200
YGEYFPGTGD LRDIGAGKGK YYAVNYALRD GIDDESYEAI FKPVMSKVME 250
MFQPSAVVLQ CGADSLSGDR LGCFNLTIKG HAKCVEFIKT FNLPLLMLGG 300
GGYTIRNVAR CWTYETAVAL DSEIPNELPY NDYFEYFGPD FKLHISPSNM 350
TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQAVAEDSIH DDSGEEDEDD 400
PDKRISIRSS DKRIACDEEF SDSEDEGEGG RKNVANFKKV KRVKTEEEKE 450
GEDKKDVKEE EKAKDEKTDS KRVKEETKSV 480
Length:480
Mass (Da):54,748
Last modified:November 1, 1996 - v1
Checksum:i7B831822235DADB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78454 mRNA. Translation: CAA55211.1.
BC081136 mRNA. Translation: AAH81136.1.
PIRiS60381.
RefSeqiNP_001081491.1. NM_001088022.1.
UniGeneiXl.47990.

Genome annotation databases

GeneIDi397868.
KEGGixla:397868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78454 mRNA. Translation: CAA55211.1 .
BC081136 mRNA. Translation: AAH81136.1 .
PIRi S60381.
RefSeqi NP_001081491.1. NM_001088022.1.
UniGenei Xl.47990.

3D structure databases

ProteinModelPortali Q91695.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q91695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397868.
KEGGi xla:397868.

Organism-specific databases

CTDi 397868.
Xenbasei XB-GENE-6252325. hdac1.

Phylogenomic databases

HOVERGENi HBG057112.
KOi K06067.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Xenopus HDm, a maternally expressed histone deacetylase, belongs to an ancient family of acetyl-metabolizing enzymes."
    Ladomery M.R., Lyons S., Sommerville J.
    Gene 198:275-280(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Oocyte.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Oocyte.
  3. "Maternal histone deacetylase is accumulated in the nuclei of Xenopus oocytes as protein complexes with potential enzyme activity."
    Ryan J., Llinas A.J., White D.A., Turner B.M., Sommerville J.
    J. Cell Sci. 112:2441-2452(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH RBBP4.

Entry informationi

Entry nameiHDA1A_XENLA
AccessioniPrimary (citable) accession number: Q91695
Secondary accession number(s): Q66IY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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