Reviewed, UniProtKB/Swiss-Prot Q91695 (HDA1A_XENLA)

Names and origin

Protein names

Recommended name:
    Probable histone deacetylase 1-A
      Short name=HD1
    EC=3.5.1.98
Alternative name(s):
    Maternally-expressed histone deacetylase
    HDM
    AB21

Gene names

Name:

hdac1-A

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Histone deacetylase that is only required during early steps of development. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subunit structure	Part of a large multiprotein complex that also contains RBBP4.
Subcellular location	Nucleus.
Tissue specificity	Oocyte. Ref.3
Developmental stage	Expressed both maternally and zygotically. Accumulates in previtellogenic oocytes and is maintained at constant level throughout oogenesis and into early embryogenesis. Declines through gastrula to neurula. Not detectable between neurula and tailbud, nor in adult tissues other than ovary. Ref.3
Sequence similarities	Belongs to the histone deacetylase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Developmental protein Hydrolase Repressor
Gene Ontology (GO)
Biological process	histone deacetylation Inferred from electronic annotation. Source: InterPro multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone deacetylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 480	480	Probable histone deacetylase 1-A		PRO_0000114691
Regions
	Region	10 – 321	312	Histone deacetylase
	Compositional bias	299 – 302	4	Poly-Gly
Sites
	Active site	141	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91695-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7B831822235DADB5	FASTA	480	54,748
	10 20 30 40 50 60 MALTLGTKKK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIFRPHKAS 70 80 90 100 110 120 AEDMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSAGGSVAS 130 140 150 160 170 180 AVKLNKQQTD ISVNWSGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV VYIDIDIHHG 190 200 210 220 230 240 DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYALRD GIDDESYEAI 250 260 270 280 290 300 FKPVMSKVME MFQPSAVVLQ CGADSLSGDR LGCFNLTIKG HAKCVEFIKT FNLPLLMLGG 310 320 330 340 350 360 GGYTIRNVAR CWTYETAVAL DSEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE 370 380 390 400 410 420 KIKQRLFENL RMLPHAPGVQ MQAVAEDSIH DDSGEEDEDD PDKRISIRSS DKRIACDEEF 430 440 450 460 470 480 SDSEDEGEGG RKNVANFKKV KRVKTEEEKE GEDKKDVKEE EKAKDEKTDS KRVKEETKSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Xenopus HDm, a maternally expressed histone deacetylase, belongs to an ancient family of acetyl-metabolizing enzymes." Ladomery M.R., Lyons S., Sommerville J. Gene 198:275-280(1997) [PubMed: 9370292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Oocyte.
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Oocyte.
[3]	"Maternal histone deacetylase is accumulated in the nuclei of Xenopus oocytes as protein complexes with potential enzyme activity." Ryan J., Llinas A.J., White D.A., Turner B.M., Sommerville J. J. Cell Sci. 112:2441-2452(1999) [PubMed: 10381399] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH RBBP4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X78454 mRNA. Translation: CAA55211.1. BC081136 mRNA. Translation: AAH81136.1.
PIR	S60381.
RefSeq	NP_001081491.1.
UniGene	Xl.47990
3D structure databases
HSSP	HSSP built from PDB template 1C3P based on UniProtKB O67135.
ModBase	Search...
Genome annotation databases
GeneID	397868.
KEGG	xla:397868.
Organism-specific databases
CTD	397868.
Phylogenomic databases
HOVERGEN	Q91695.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit. PTHR10625:SF28. His_deacetylse_1. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037913. His_deacetylse_1. 1 hit.
PRINTS	PR01270. HDASUPER. PR01271. HISDACETLASE.
ProtoNet	Search...

Entry information

Entry name

HDA1A_XENLA

Accession

Primary (citable) accession number: Q91695
Secondary accession number(s): Q66IY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	September 22, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project