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Q91695 (HDA1A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable histone deacetylase 1-A

Short name=HD1-A
EC=3.5.1.98
Alternative name(s):
AB21
HDM
Maternally-expressed histone deacetylase
Gene names
Name:hdac1-a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Histone deacetylase that is only required during early steps of development. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subunit structure

Part of a large multiprotein complex that also contains RBBP4.

Subcellular location

Nucleus.

Tissue specificity

Oocyte. Ref.3

Developmental stage

Expressed both maternally and zygotically. Accumulates in previtellogenic oocytes and is maintained at constant level throughout oogenesis and into early embryogenesis. Declines through gastrula to neurula. Not detectable between neurula and tailbud, nor in adult tissues other than ovary. Ref.3

Sequence similarities

Belongs to the histone deacetylase family. HD type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480Probable histone deacetylase 1-A
PRO_0000114691

Regions

Region10 – 321312Histone deacetylase
Compositional bias299 – 3024Poly-Gly

Sites

Active site1411 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91695 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7B831822235DADB5

FASTA48054,748
        10         20         30         40         50         60 
MALTLGTKKK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIFRPHKAS 

        70         80         90        100        110        120 
AEDMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSAGGSVAS 

       130        140        150        160        170        180 
AVKLNKQQTD ISVNWSGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV VYIDIDIHHG 

       190        200        210        220        230        240 
DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYALRD GIDDESYEAI 

       250        260        270        280        290        300 
FKPVMSKVME MFQPSAVVLQ CGADSLSGDR LGCFNLTIKG HAKCVEFIKT FNLPLLMLGG 

       310        320        330        340        350        360 
GGYTIRNVAR CWTYETAVAL DSEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE 

       370        380        390        400        410        420 
KIKQRLFENL RMLPHAPGVQ MQAVAEDSIH DDSGEEDEDD PDKRISIRSS DKRIACDEEF 

       430        440        450        460        470        480 
SDSEDEGEGG RKNVANFKKV KRVKTEEEKE GEDKKDVKEE EKAKDEKTDS KRVKEETKSV 

« Hide

References

« Hide 'large scale' references
[1]"Xenopus HDm, a maternally expressed histone deacetylase, belongs to an ancient family of acetyl-metabolizing enzymes."
Ladomery M.R., Lyons S., Sommerville J.
Gene 198:275-280(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Oocyte.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Oocyte.
[3]"Maternal histone deacetylase is accumulated in the nuclei of Xenopus oocytes as protein complexes with potential enzyme activity."
Ryan J., Llinas A.J., White D.A., Turner B.M., Sommerville J.
J. Cell Sci. 112:2441-2452(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH RBBP4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78454 mRNA. Translation: CAA55211.1.
BC081136 mRNA. Translation: AAH81136.1.
PIRS60381.
RefSeqNP_001081491.1. NM_001088022.1.
UniGeneXl.47990.

3D structure databases

ProteinModelPortalQ91695.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ91695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397868.
KEGGxla:397868.

Organism-specific databases

CTD397868.
XenbaseXB-GENE-6252325. hdac1.

Phylogenomic databases

HOVERGENHBG057112.
KOK06067.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Entry information

Entry nameHDA1A_XENLA
AccessionPrimary (citable) accession number: Q91695
Secondary accession number(s): Q66IY9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families