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Q91695

- HDA1A_XENLA

UniProt

Q91695 - HDA1A_XENLA

Protein

Probable histone deacetylase 1-A

Gene

hdac1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Histone deacetylase that is only required during early steps of development. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei141 – 1411By similarity

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Developmental protein, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable histone deacetylase 1-A (EC:3.5.1.98)
    Short name:
    HD1-A
    Alternative name(s):
    AB21
    HDM
    Maternally-expressed histone deacetylase
    Gene namesi
    Name:hdac1-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6252325. hdac1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480Probable histone deacetylase 1-APRO_0000114691Add
    BLAST

    Proteomic databases

    PRIDEiQ91695.

    Expressioni

    Tissue specificityi

    Oocyte.1 Publication

    Developmental stagei

    Expressed both maternally and zygotically. Accumulates in previtellogenic oocytes and is maintained at constant level throughout oogenesis and into early embryogenesis. Declines through gastrula to neurula. Not detectable between neurula and tailbud, nor in adult tissues other than ovary.1 Publication

    Interactioni

    Subunit structurei

    Part of a large multiprotein complex that also contains RBBP4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91695.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni10 – 321312Histone deacetylaseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi299 – 3024Poly-Gly

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG057112.
    KOiK06067.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    Q91695-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALTLGTKKK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK    50
    MEIFRPHKAS AEDMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC 100
    PVFDGLFEFC QLSAGGSVAS AVKLNKQQTD ISVNWSGGLH HAKKSEASGF 150
    CYVNDIVLAI LELLKYHQRV VYIDIDIHHG DGVEEAFYTT DRVMTVSFHK 200
    YGEYFPGTGD LRDIGAGKGK YYAVNYALRD GIDDESYEAI FKPVMSKVME 250
    MFQPSAVVLQ CGADSLSGDR LGCFNLTIKG HAKCVEFIKT FNLPLLMLGG 300
    GGYTIRNVAR CWTYETAVAL DSEIPNELPY NDYFEYFGPD FKLHISPSNM 350
    TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQAVAEDSIH DDSGEEDEDD 400
    PDKRISIRSS DKRIACDEEF SDSEDEGEGG RKNVANFKKV KRVKTEEEKE 450
    GEDKKDVKEE EKAKDEKTDS KRVKEETKSV 480
    Length:480
    Mass (Da):54,748
    Last modified:November 1, 1996 - v1
    Checksum:i7B831822235DADB5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78454 mRNA. Translation: CAA55211.1.
    BC081136 mRNA. Translation: AAH81136.1.
    PIRiS60381.
    RefSeqiNP_001081491.1. NM_001088022.1.
    UniGeneiXl.47990.

    Genome annotation databases

    GeneIDi397868.
    KEGGixla:397868.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78454 mRNA. Translation: CAA55211.1 .
    BC081136 mRNA. Translation: AAH81136.1 .
    PIRi S60381.
    RefSeqi NP_001081491.1. NM_001088022.1.
    UniGenei Xl.47990.

    3D structure databases

    ProteinModelPortali Q91695.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q91695.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397868.
    KEGGi xla:397868.

    Organism-specific databases

    CTDi 397868.
    Xenbasei XB-GENE-6252325. hdac1.

    Phylogenomic databases

    HOVERGENi HBG057112.
    KOi K06067.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Xenopus HDm, a maternally expressed histone deacetylase, belongs to an ancient family of acetyl-metabolizing enzymes."
      Ladomery M.R., Lyons S., Sommerville J.
      Gene 198:275-280(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Oocyte.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Oocyte.
    3. "Maternal histone deacetylase is accumulated in the nuclei of Xenopus oocytes as protein complexes with potential enzyme activity."
      Ryan J., Llinas A.J., White D.A., Turner B.M., Sommerville J.
      J. Cell Sci. 112:2441-2452(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH RBBP4.

    Entry informationi

    Entry nameiHDA1A_XENLA
    AccessioniPrimary (citable) accession number: Q91695
    Secondary accession number(s): Q66IY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3