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Protein

Dual specificity protein phosphatase

Gene

dusp6

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei290Phosphocysteine intermediateUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, KinaseImported, Protein phosphataseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation, EC:3.1.3.48UniRule annotation)
Gene namesi
Name:dusp6Imported
Synonyms:MGC68682Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-978223. dusp6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 147RhodaneseInterPro annotationAdd BLAST119
Domaini203 – 345Tyrosine-protein phosphataseInterPro annotationAdd BLAST143
Domaini259 – 327TYR_PHOSPHATASE_2InterPro annotationAdd BLAST69

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.UniRule annotation

Phylogenomic databases

HOVERGENiHBG007347.
KOiK04459.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEKLRPAAP LDMALGKSVS WLNEQLDVAN ERLLLMDCRA HELYESSHIE
60 70 80 90 100
AAMNVAIPGI MLRRLKKGNL PIRSLFACGE DRDKFARRCG TDTVVLYDEN
110 120 130 140 150
SCDWNENTAG ESVLGLLMKR LKDEGCRAFY LEGGFNKFQS EYPIHCETNL
160 170 180 190 200
DSSCSSSSPP VLGLGGLRIS SDSSSDIESD IDRDPSSATD SDGSPLSNPQ
210 220 230 240 250
PSFPVEILPY LYLGCAKDST NLDVLEEFGI KYILNVTPNL PNLFENAGEF
260 270 280 290 300
RYKQIPISDH WSQNLSQFFP EAISFIDEAR GKSCGVLVHC LAGISRSVTV
310 320 330 340 350
TVAYLMQKLN LSMNDAYDIV KMKKSNISPN FNFMGQLLDF ERTLGLSSPC
360 370
DNRVPAQQLY FTNPANQNVY QVDSMQST
Length:378
Mass (Da):42,037
Last modified:November 1, 1996 - v1
Checksum:iF274D4CAE960B783
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43223 mRNA. Translation: AAA85240.1.
BC059985 mRNA. Translation: AAH59985.1.
RefSeqiNP_001083256.1. NM_001089787.1.
UniGeneiXl.31935.

Genome annotation databases

GeneIDi398829.
KEGGixla:398829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43223 mRNA. Translation: AAA85240.1.
BC059985 mRNA. Translation: AAH59985.1.
RefSeqiNP_001083256.1. NM_001089787.1.
UniGeneiXl.31935.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398829.
KEGGixla:398829.

Organism-specific databases

CTDi1848.
XenbaseiXB-GENE-978223. dusp6.

Phylogenomic databases

HOVERGENiHBG007347.
KOiK04459.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ91663_XENLA
AccessioniPrimary (citable) accession number: Q91663
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.