Q91663 (Q91663_XENLA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dual specificity protein phosphatase PIRNR PIRNR000939
EC=3.1.3.16 PIRNR PIRNR000939
EC=3.1.3.48 PIRNR PIRNR000939

Gene names

Name:	dusp6 Xenbase XB-GENE-978223
Synonyms:	MGC68682 EMBL AAH59985.1

Organism

Xenopus laevis (African clawed frog) EMBL AAA85240.1

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate. PIRNR PIRNR000939 Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. PIRNR PIRNR000939
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. PIRNR PIRNR000939

Ontologies

Keywords
Molecular function	Hydrolase Kinase EMBL AAA85240.1 Protein phosphatase PIRNR PIRNR000939 Transferase
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	290	1	Phosphocysteine intermediate By similarity PIRSR PIRSR000939-1

Sequences

	Sequence		Length	Mass (Da)
	Q91663 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F274D4CAE960B783	FASTA	378	42,037
	10 20 30 40 50 60 MLEKLRPAAP LDMALGKSVS WLNEQLDVAN ERLLLMDCRA HELYESSHIE AAMNVAIPGI 70 80 90 100 110 120 MLRRLKKGNL PIRSLFACGE DRDKFARRCG TDTVVLYDEN SCDWNENTAG ESVLGLLMKR 130 140 150 160 170 180 LKDEGCRAFY LEGGFNKFQS EYPIHCETNL DSSCSSSSPP VLGLGGLRIS SDSSSDIESD 190 200 210 220 230 240 IDRDPSSATD SDGSPLSNPQ PSFPVEILPY LYLGCAKDST NLDVLEEFGI KYILNVTPNL 250 260 270 280 290 300 PNLFENAGEF RYKQIPISDH WSQNLSQFFP EAISFIDEAR GKSCGVLVHC LAGISRSVTV 310 320 330 340 350 360 TVAYLMQKLN LSMNDAYDIV KMKKSNISPN FNFMGQLLDF ERTLGLSSPC DNRVPAQQLY 370 FTNPANQNVY QVDSMQST

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mesoderm induction in Xenopus caused by activation of MAP kinase." Umbhauer M., Marshall C.J., Mason C.S., Old R.W., Smith J.C. Nature 376:58-62(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"A novel MAP kinase phosphatase is localised in the branchial arch region and tail tip of Xenopus embryos and is inducible by retinoic acid." Mason C., Lake M., Nebreda A., Old R. Mech. Dev. 55:133-144(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Branchial arch region EMBL AAA85240.1.
[3]	NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney EMBL AAH59985.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U43223 mRNA. Translation: AAA85240.1. BC059985 mRNA. Translation: AAH59985.1.
RefSeq	NP_001083256.1. NM_001089787.1.
UniGene	Xl.31935.
3D structure databases
HSSP	HSSP built from PDB template 1MKP based on UniProtKB Q16828.
SMR	Q91663. Positions 1-153, 202-344.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	398829.
KEGG	xla:398829.
Organism-specific databases
CTD	1848.
Xenbase	XB-GENE-978223. dusp6.
Phylogenomic databases
HOVERGEN	HBG007347.
KO	K04459.
Family and domain databases
Gene3D	3.40.250.10. 1 hit.
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR008343. MKP. IPR001763. Rhodanese-like_dom. IPR000387. Tyr/Dual-sp_Pase. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. PF00581. Rhodanese. 1 hit. [Graphical view]
PIRSF	PIRSF000939. MAPK_Ptase. 1 hit.
PRINTS	PR01764. MAPKPHPHTASE.
SMART	SM00195. DSPc. 1 hit. SM00450. RHOD. 1 hit. [Graphical view]
SUPFAM	SSF52821. Rhodanese-like. 1 hit.
PROSITE	PS50206. RHODANESE_3. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q91663_XENLA

Accession

Primary (citable) accession number: Q91663

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)