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Protein
Submitted name:

XIR

Gene

kcnj5

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei201Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Potassium transportUniRule annotationSAAS annotation, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Submitted name:
XIRImported
Gene namesi
Name:kcnj5Imported
Synonyms:xirImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5919514. kcnj5.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei110 – 133HelicalSequence analysisAdd BLAST24
Transmembranei187 – 210HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ91658.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG006178.
KOiK04999.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPERMAPSP QWKRLYESPQ LIQTIMARDL RVSMNQDLKV DITPKKLPKQ
60 70 80 90 100
AREDPKRSID RTHLLFEHKK PRQRYMEKDG KCNVHHGNVK ETYRYFSDLF
110 120 130 140 150
TTLVDLKWHF SLFIFTLVYT VTWLFFGLIW WLIAYIRGDL DHLGDKNWVP
160 170 180 190 200
CVENLNGFVS AFLFSIETET TIGYGYRVIT EKCPEGIVLL LVQAILGSIV
210 220 230 240 250
NALMVGCMFV KISQPKKRAE TLMFSNNAVI SLRDGKLCLM FRVGDLRSSH
260 270 280 290 300
IVEASIRAKL IKSKQTKEGE FIPLNQTDIN VGFDTGDDRL FLVSPLIISH
310 320 330 340 350
EINEKSPFWE MSRTQLEIEE FEIVVILEGM VEATGMTCQA RSSYVDSEVL
360 370 380 390 400
WGHRFIPVLT LEKGFYEVDY TTFHDNYETP TPSCSAKELK EIQHGEQVLH
410 420
HTYTGQRKNS AQNGAPLGSE DLNRRTQPD
Length:429
Mass (Da):49,492
Last modified:November 1, 1996 - v1
Checksum:i2D116CE2592899EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42207 mRNA. Translation: AAB53154.1.
RefSeqiNP_001156864.1. NM_001163392.1.
UniGeneiXl.23590.

Genome annotation databases

GeneIDi378557.
KEGGixla:378557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42207 mRNA. Translation: AAB53154.1.
RefSeqiNP_001156864.1. NM_001163392.1.
UniGeneiXl.23590.

3D structure databases

ProteinModelPortaliQ91658.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378557.
KEGGixla:378557.

Organism-specific databases

CTDi3762.
XenbaseiXB-GENE-5919514. kcnj5.

Phylogenomic databases

HOVERGENiHBG006178.
KOiK04999.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ91658_XENLA
AccessioniPrimary (citable) accession number: Q91658
Secondary accession number(s): Q91659
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.