Kinesin-like protein KIF2C - Xenopus laevis (African clawed frog)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF2C

Alternative name(s):
Kinesin central motor 1
Short name=xKCM1

Gene names

Name:	kif2c
Synonyms:	kcm1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	730 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

Promotes ATP-dependent removal of tubulin dimers from microtubules. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Ref.1

Subcellular location

Cytoplasm › cytoskeleton. Nucleus. Chromosome › centromere By similarity. Chromosome › centromere › kinetochore By similarity Ref.1 Ref.4.

Sequence similarities

Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily.

Contains 1 kinesin-motor domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Chromosome partition Mitosis
Cellular component	Centromere Chromosome Cytoplasm Cytoskeleton Kinetochore Microtubule Nucleus
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW chromosome segregation Inferred from electronic annotation. Source: UniProtKB-KW microtubule-based movement Inferred from electronic annotation. Source: InterPro mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 730

730

Kinesin-like protein KIF2C

PRO_0000125422

Regions

Domain

257 – 598

342

Kinesin-motor

Nucleotide binding

352 – 359

8

ATP By similarity

Region

1 – 256

256

Globular Potential

Region

211 – 242

32

Negative regulator of microtubule-binding By similarity

Coiled coil

599 – 730

132

Potential

Sites

Binding site

268

1

ATP By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q91636 [UniParc].

Last modified May 4, 2001. Version 2.
Checksum: 25C31C187E491523
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FASTA

730

82,586

        10         20         30         40         50         60 
MERLVATRLV TGLAVKIMRS NGVIHNANIT SVNMDRSSVN VEWKEGEANK GKEISFADVI 

        70         80         90        100        110        120 
SVNPELLDAV LAPTNVKENM PPQRNVSSQN HKRKTISKIP APKEVAAKNS LLSESGAQSV 

       130        140        150        160        170        180 
LRERSTRMTA IHETLPYENE MEAESTPLPI QQNSVQARSR STKVSIAEEP RLQTRISEIV 

       190        200        210        220        230        240 
EESLPSGRNN QGRRKSNIVK EMEKMKNKRE EQRAQNYERR MKRAQDYDTS VPNWEFGKMI 

       250        260        270        280        290        300 
KEFRATMDCH RISMADPAEE HRICVCVRKR PLNKQELSKK EIDIISVPSK NIVLVHEPKL 

       310        320        330        340        350        360 
KVDLTKYLEN QAFRFDFSFD ETATNEVVYR FTARPLVQSI FEGGKATCFA YGQTGSGKTH 

       370        380        390        400        410        420 
TMGGDFSGKS QNVSKGVYAF ASRDVFLLLD QPRYKHLDLD VFVTFFEIYN GKVFDLLNKK 

       430        440        450        460        470        480 
TKLRVLEDAK QEVQVVGLLE KQVISADDVF KMIEIGSACR TSGQTFANTS SSRSHACLQI 

       490        500        510        520        530        540 
ILRRGSKLHG KFSLVDLAGN ERGVDTASAD RITRMEGAEI NRSLLALKEC IRALGQNKSH 

       550        560        570        580        590        600 
TPFRESKLTQ ILRDSFIGEN SRTCMIAMLS PGFNSCEYTL NTLRYADRVK ELSPQNAETN 

       610        620        630        640        650        660 
DDNLQMEDSG GSHASIEGLQ LQDDFLLKDE ELSTHNSFQD ALNRVGELED KAVDELRELV 

       670        680        690        700        710        720 
QKEPEWTNLL QMTEQPDYDL ENFVMQAEYL IQERSKVLIA LGDSINSLRL ALQVEEQASK 

       730 
QISKKKRSNK

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly." Walczak C.E., Mitchison T.J., Desai A. Cell 84:37-47(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION. Tissue: Ovary.
[2]	Walczak C.E. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 516.
[3]	NIH - Xenopus Gene Collection (XGC) project Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[4]	"An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin." Ohi R., Coughlin M.L., Lane W.S., Mitchison T.J. Dev. Cell 5:309-321(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MTUS1, SUBCELLULAR LOCATION, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U36485 mRNA. Translation: AAC59743.2. BC044976 mRNA. Translation: AAH44976.1.
RefSeq	NP_001080314.1. NM_001086845.1.
UniGene	Xl.43865.
3D structure databases
ProteinModelPortal	Q91636.
SMR	Q91636. Positions 232-593.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q91636. 2 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	380006.
KEGG	xla:380006.
Organism-specific databases
CTD	11004.
Xenbase	XB-GENE-961451. kif2c.
Phylogenomic databases
HOVERGEN	HBG003875.
KO	K10393.
Family and domain databases
Gene3D	3.40.850.10. 1 hit.
InterPro	IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. [Graphical view]
Pfam	PF00225. Kinesin. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. [Graphical view]
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KIF2C_XENLA

Accession

Primary (citable) accession number: Q91636
Secondary accession number(s): Q5D0B4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 4, 2001
Last modified:	April 3, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents